| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | The adaptive and reactive barrier |
| Discussion Leader: Neil Kitson (UBC, Canada) |
| 7:40 pm - 8:05 pm | Daniel Maes (Estee Lauder, US)
"Body site, seasonal, psychological, gender & racial differences in barrier function" |
| 8:05 pm - 8:12 pm | Discussion |
| 8:12 pm - 8:47 pm | Brian Nickoloff (University Of Chicago Medical Center, USA)
"Cracking the Cytokine Code Contributing to Barrier Dysfunction in Psoriatic Plaques" |
| 8:47 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:20 pm | Michael Cork (Children's Hospital, Sheffield, UK)
"Barrier functionality & repair - a clinical view" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Stratum corneum formation and maturation |
| Discussion Leader: Tony Rawlings (AVR Consulting Ltd, UK) |
| 9:00 am - 9:30 am | Eleftherios Diamandis (Mount Sinai Hospital, Canada)
"Desquamation : Whats new?" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Michel Simon (Faculté de Médecine, Toulouse Cedex, France)
"Peptidylarginine deiminase isoenzymes & function" |
| 10:10 am - 10:15 am | Discussion |
| 10:15 am | Coffee Break / Group Photo |
| 10:50 am - 11:20 am | Erwin Tschachler (Medical University of Vienna, Austria)
"Differentiation or apoptosis?" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Irwin McClean (University of Dundee, United Kingdom)
"Functions of filaggrin & associated genes" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Hot Topic: Sheree Cross (University of Queensland, Australia)
"Skin surfactant Proteins" |
| 12:20 pm - 12:30 pm | Poster Talk: Carolyn Byrne (Queen Mary University of London)
"AKT signaling in skin barrier development and homeostasis" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Strategies to maximise and assess skin penetration |
| Discussion Leader: Mike Roberts (University of Queensland, Australia) |
| 7:30 pm - 8:00 pm | Annette Bunge (Colorado School of Mines, USA)
"Interplay of formulation thermodynamics, solute structure and the skin barrier" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Richard Guy (University of Bath, UK)
"Assessment of topical drug delivery and bioavailability" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Russ Potts (Russ Potts Consulting, USA)
"Getting our products to where it matters" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm - 11:00 pm | Poster Session |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Emerging epidermal barrier functions |
| Discussion Leader: Walt Holleran (VA Medical Centre, San Francisco, USA) |
| 9:00 am - 9:30 am | Ken Feingold (VA Medical Centre, San Francisco, USA)
"The ABCs of Permeability Barrier Homeostasis" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Faith Williams (Toxicology Unit, University of Newcastle, UK)
"Epidermal transporters and skin metabolism" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Hot Topic: Julia Caussin (Leiden/Amsterdam Center for Drug Research, The Netherlands)
"How moisturisers work on barrier function" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Richard Gallo (University of California, San Diego, USA.)
"Antimicrobial and other defense mechanisms" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Des Tobin (University of Bradford, UK)
"Sensing the environment" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | Poster Talk: Charles Roch-Philippe (University of Lausanne)
"The sodium channel ENaC is required for the post-natal maturation of the epidermal permeability barrier function" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Skin biomechanics |
| Discussion Leader: Howard Maibach (UCSF, USA) |
| 7:30 pm - 7:55pm | Birgit Lane (Proteos, Singapore)
"Keratinocyte mechanics & keratin remodeling" |
| 7:55 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:25 pm | Reiner Dauskardt (Stanford University, USA)
"Stratum corneum biomechanics" |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:55 pm | Mark Kendall (University of Queensland, Australia)
"Skin mechanical properties - what is needed to pierce the barrier?" |
| 8:55 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:25 pm | Howard Maibach (UCSF, USA)
"What Bioengineering Does and Does Not offer!" |
| 9:25 pm - 9:30 pm | Discussion |
| 9:30 pm - 11:00 pm | Poster Session |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Consequences of affecting or crossing the skin barrier |
| Discussion Leader: Bill Dressler (Huntingtown, USA) |
| 9:00 am - 9:30 am | Chris Anderson (University of Linkoping, Sweden)
"Response, wound repair & clinical issues associated with breaching the barrier" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Nancy Monteiro-Riviere (NCSU, USA)
"Dermal effects of nanomaterials and other topical products" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Hot Topic: Guang Wei Lu (Pfizer, US)
"Sebum and Drug Penetration" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Gerhard Nohynek (L’Oreal R&D, France)
"Minimizing the potential adverse effects of hairdyes, cosmetics and cosmeceuticals" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Bob Bronaugh (FDA, USA)
"Regulatory issues, emphasizing modifying the SC reservoir and effects of nanoparticles" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | Poster Talk: Jyoti Gupta (Georgia Institute of Technology)
"Skin Barrier Recovery After Microneedle Treatment in Human Subjects" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote talk, Hot Topics & Young Investigators Session |
| Discussion Leaders: Steven Hoath (Cincinnati Children’s Hospital Medical Center, USA) and Jerry Kasting (University of Cincinnati College of Pharmacy, USA |
| 7:30 pm - 8:15 pm | Keynote Talk: Peter Elias (UCSF, USA)
"How Barrier Dysfunction Trumps Immunological Abnormalities in Atopic Dermatitis" |
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:35 pm | Hot Topic: Audra Stinchcomb (UK College of Pharmacy, USA)
"Prodrugs and codrugs as strategies to improve percutaneous absorption" |
| 8:35 pm - 8:45 pm | Mei Li (CERBM-GIE - I.G.B.M.C, CEDEX.)
"Keratinocytic nuclear receptors are involved in the pathogenesis of atopic dermatitis" |
| 8:45 pm - 8:55 pm | Johanna Brandner (University Hospital Hamburg-Eppendorf)
"Regulation of Epidermal Tight-Junctions (TJ) during Staphylococcal Skin Infections" |
| 8:55 pm - 9:05 pm | Hot Topic: Jim Riviere (NCSU, USA)
"Mixed solvents and skin permeability" |
| 9:05 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:30 pm | Discussion: Jerry Kasting (University of Cincinatti, USA), Yuri Dancik and Owen Jepps (University of Queensland, Australia)
"Dermis transport" |
| 9:30 pm - 11:00 pm | Poster Session |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Lifestyle and barrier function |
| Discussion Leader: Raman Govindarajan (Johnson & Johnson Asia Pacific, Singapore) |
| 9:00 am - 9:30 am | Jens Thiele (Boston University, USA)
"Effects of antioxidants on the skin barrier" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Johan Wiechers (Uniqema - The Netherlands)
"Cosmeceutical formulation strategies that deliver" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:30 am | Hot Topic: Florence Puch (Danone Research, France)
"Improving SC water barrier function" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Dominique Bernard (L'Oreal, France)
"Sensitive skin: a neurological perspective" |
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 12:10 pm | Juergen Lademann (Charité Hospital, Berlin, Germany)
"How to achieve effective targeting and response via sweat ducts and follicles" |
| 12:10 pm - 12:20 pm | Discussion |
| 12:20 pm - 12:30 pm | Poster Talk: Mikhail Kiselev (Joint Institute for Nuclear Research)
"Significance of the fully extended conformation of ceramide molecules in the nanostructure of stratum corneum" |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair(s); Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair(s)) |
| 7:30 pm - 9:30 pm | DEBATE - Do corneocytes leak? |
| Discussion Leader: Adrian Williams (University of Reading, UK) |
| Leader Pro Team: Ken Walters (An-eX, UK) |
| Leader Con Team: Joke Bouwstra (Leiden University, THE NETHERLANDS) |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
