Afternoon - Arrival and Registration
6:00 - Opening Reception
Sunday, August 15, 7:30-9:30 PM
Session I | Current Concepts of the Brain Barriers |
| Chairpersons: | Joan N. Abbott - King's College, London, UK
Norman R. Saunders - University of Tasmania, Australia |
- Joseph D. Fenstermacher - Henry Ford Hospital. Detroit, MI, USA
"Anatomy, Physiology, and Interactions of the Brain Barriers."
- Malcolm B. Segal - Sherrington School of Physiology, London, UK
"The Formation of Brain ECF at the BBB and the Interactions Between CSF and the Brain ECF."
Monday, August 16, 9:00-12:30 AM
Session II | Is the Choroid Plexus or Blood-CSF Barrier Important for the Brain
Microenvironment? |
| Chairpersons: | Malcolm B. Segal - Sherrington School of Physiology, London, UK
Joseph D. Fenstermacher - Henry Ford Hospital, Detroit, MI, USA |
8:30: Group Photo
- Adam Chodobski - Brown University, Providence, RI, USA
"Choroid Plexus: Not Only for CSF Production."
- Jean F. Ghersi-Egea - INSERM, Faculte de Medecine RTH Laennec, Lyon, France
"Implication of the Choroid Plexus and Other Blood-Brain Interfaces in Cerebral Detoxication Processes."
10:35-10:55: Coffee Break
- Nathalie Strazielle - INSERM, Faculte de Medecine RTH Laennec, Lyon, France
"Contribution of Cell Culture Models to the Investigation of Transport Mechanisms at the Blood-CSF Barrier."
- Marc R. Del Bigio - University of Manitoba, Manitoba, Canada
"Ependymal Barrier Function and Alterations in Brain Fluids in Hydrocephalus."
12:30 (prompt): Lunch
4:00: Drinks and snacks
6:00: Candlelight Dinner
Monday, August 16, 7:30-9:30 PM
Session III | Development of the BBB and Blood-CSF Barrier |
| Chairperson: | Conrad E. Johanson - Brown University, Providence, RI, USA |
- Katarzyna Dziegielewska - University of Tasmania, Tasmania, Australia
"Bypassing the Barrier."
- Hazel Jones - University of Florida, Gainesville, FL, USA
"Molecular Markers and Mechanisms in BBB Development."
- Norman R. Saunders - University of Tasmania, Tasmania, Australia
"Barriers in the Developing Brain: Structural and Functional Aspects."
Tuesday, August 17, 9:00-12:30 AM
Session IV | Physiology and Pathophysiology of the BBB. Cellular and Molecular Aspects |
| Chairperson: | Lester R. Drewes - University of Minnesota, Duluth, MN, USA |
- Joan N. Abbott - King's College, London, UK
"In vitro models of the BBB."
- Milton W. Brightman - NIH, Bethesda, MD, USA
"The Interactions of Astroglia and the Brain Endothelium."
10:35-10:55: Coffee Break
- John Greenwood - University College, London, UK
"Brain Endothelial Cell Signaling Pathways Involved in the Support of T Lymphocyte Migration."
- Maria Spatz - NIH, Bethesda, MD, USA
"The Role of Endothelin and NO in the BBB Function."
12:30 (prompt): Lunch
4:00-6:00: Poster Session #1
6:00: Dinner
Tuesday, August 17, 7:30-9:30 PM
Session V
| Drug Delivery to the Brain. New Strategies for the Treatment of Brain Diseases (part I) |
| Chairpersons: |
Edward A. Neuwelt - Oregon Health Sciences University, Oregon, OR, USA
Tom Davis - University of Arizona, Tucson, AZ., USA |
- Quentin R. Smith - Texas Technical University, Texas, TX, USA
"Designing Drugs for Facilitating Delivery to the Brain. Study with the L-system."
- Raymond T. Bartus - Alkermes, Inc., Cambridge, MA, USA
"Increasing Delivery to the Brain by Pharmacological Modulation of the BBB."
Wednesday, August 18, 9:00-12:30 AM
Session VI | Drug Delivery to the Brain. New Strategies for the Treatment of Brain Diseases (part II) |
| Chairperson: | Raymond T. Bartus - Alkermes Inc., Cambridge, MA, USA |
- William M. Pardridge - UCLA School of Medicine, Los Angeles, CA, USA
"New Drug Delivery Through the BBB."
- Edward A. Neuwelt - Oregon Health Sci. Univ., Oregon, OR, USA
"Outwitting of the BBB to Deliver Drugs, Proteins and Viruses."
10:35-10:55: Coffee Break
- Renata Pasqualini - Burnham Institute, La Jolla, CA, USA
"Vasculature Targetting."
- Brian E. Wojcik - Brown University, Providence, RI, USA
"Gene Delivery Across the BBB."
6:00: Dinner
Wednesday, August 18, 7:30-9:30 PM
| Diseases which Impact on the BBB (part I) |
| Chairpersons: | Giora Z. Feuerstein - DuPont Pharm., Wilmington, DE, USA
Berislav Zlokovic - University of Southern California, Los Angeles, CA, USA |
- Richard M. McCarron - Naval Medical Research Inst., Bethesda, MD, USA
"Possible Mechanisms of Adhesion Molecule Expression and their Role in Stroke."
- Richard F. Keep - University of Michigan, Michigan, MI, USA
"BBB in Cerebral Ischemia."
9:00-9:30: Business Meeting
Thursday, August 19, 9:00-12:30 AM
Session VIII | Diseases which Impact on the BBB (part II) |
| Chairpersons: | John Greenwood - University College, London, UK
Joseph D. Fenstermacher - Henry Ford Hospital, Detroit, MI, USA
Elaine I. Tuomanen - St. Jude Children' s Res. Hospital, Memphis, TN, USA |
- Carol K. Petito - Jackson Memorial Hospital, Miami, FL, USA
"Brain Barriers' Dysfunction in HIV Infection."
- William F. Hickey - Dartmouth Medical Center, Dartmouth, NH, USA
"Leukocytes and Macrophages Trafficking Across the BBB."
10:35-10:55: Coffee Break
- Berislav Zlokovic - University of Southern California, Los Angeles, CA, USA
"BBB and CNS Transport Mechanisms for Aß Peptides via Apolipoproteins J and E: Role in the Development of Cerebral Aß Amyloidosis and Alzheimer's Disease Pathology."
- Andrzej W. Vorbrodt - Inst. Basic Res. Devel. Disab., Staten Island, NY, USA
"Age-Associated Changes at the BBB."
12:30 (prompt): Lunch
4:30-6:00: Poster Session #2
6:00: Dinner
Thursday, August 19, 7:30-9:30 PM
Session IX | Immune Barriers of the Brain |
| Chairperson: | William F. Hickey - Dartmouth Medical Center, Dartmouth, NH, USA |
- Paul M. Knopf - Brown University, Providence, RI, USA
"Imposing a Bias on Immune Responses in the Brain."
- Elaine I. Tuomanen - St. Jude Children' s Res. Hospital, Memphis, TN, USA
"Penetration of Bacteria Across the BBB."
