| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:15 pm | Opening Reception and Welcome
Chair: Martha E. O'Donnell (University of California, Davis) |
| 7:30 pm - 9:30 pm | PERSPECTIVE LECTURES |
| Chairs and Discussion Leaders:
Thomas P. Davis (University of Arizona) &
Joanna Szmydynger-Chodobska (Brown University) |
| 7:30 pm - 8:30 pm | David J. Begley (King's College London)
"Overview of the Blood-Brain Barrier, Neurovascular Unit and Blood-CSF Barrier" |
| 8:30 pm - 9:30 pm | James W. Putney (NIEHS)
"Calcium Signaling Mechanisms in Epithelia: Lessons to be Learned for the Blood-Brain Barrier, Neurvascular Unit and Blood-CSF Barrier" |
| 9:30 pm | Posters to be mounted, further discussion and social occasion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Physiology and Pathophysiology of the Blood-Brain Barrier and Neurovascular Unit |
| Chair and Discussion Leader:
Danica B. Stanimirovic (University of Ottawa) |
| 9:00 am - 9:30 am | Luc Leybaert (Ghent University, Belgium)
"Ca Talk at the Blood-Brain Barrier" |
| 9:30 am - 10:00 am | Karen S. Mark (University of Missouri-Kansas City)
"Cellular Signaling Mechanisms Induced by Hypoxic Insult to the Blood-Brain Barrier" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Maiken Nedergaard (University of Rochester)
"Signaling at the Gliovascular Interface" |
| 11:00 am - 11:30 am | Eng H. Lo (Massachussetts General Hospital, Harvard)
"Thrombolysis and Proteolysis in the Neurovascular Unit" |
| 11:30 am - 12:30 pm | Formal Poster Session
(Presence of poster presenters for Session 2 mandatory) |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Afternoon free for activities and discussion |
| 4:00 pm - 6:00 pm | Reception and Social Gathering |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Physiology and Pathophysiology of the Blood-Brain Barrier and Neurovascular Unit |
| Chair and Discussion Leader:
Joel Pachter (University of Connecticut) |
| 7:30 pm - 8:00 pm | Anuska Andjelkovic-Zochowska (University of Michigan)
"Chemokines in Brain Inflammation: The Role of Chemokines in Modulation of Blood-Brain Barrier Permeability" |
| 8:00 pm - 8:30 pm | Ljiljana Krizanac-Bengez (Cleveland Clinic)
"The Role of Shear Stress in Blood-Brain Barrier Physiology: Perspectives from In Vitro Studies" |
| 8:30 pm - 9:30 pm | Four speakers selected from the day's posters |
| 9:30 pm | Posters, further discussion and social occasion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Physiology and Pathophysiology of the Blood-CSF Barrier |
| Chair and Discussion Leader:
Richard D. Egleton (University of Arizona) |
| 9:00 am - 9:30 am | Andrea J. Yool (University of Arizona)
"Physiological Relevance of Aquaporins in the Choroid Plexus" |
| 9:30 am - 10:00 am | Peter Brown (University of Manchester)
"Ion Transport as the Basis for CSF Secretion" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Serge Rivest (Université Laval, Québec, Canada)
"How the Barriers of the CNS Transfer Immunity to the Brain" |
| 11:00 am - 11:30 am | Jaleel A. Miyan (University of Manchester, England)
"Cerebrospinal Fluid: A Vital Physiological Fluid in Brain Development" |
| 11:30 am - 12:30 pm | Formal Poster Session
(Presence of poster presenters for Session 3 mandatory) |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Afternoon free for activities and discussion |
| 4:00 pm - 6:00 pm | Optional Workshop/Discussion:
"Topics in NeuroAIDS and the Blood-Brain Barrier: Interfaces Between Two Fields" |
| Chair and Discussion Leader: William A. Banks (St. Louis University) |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Physiology and Pathophysiology of the Blood-CSF Barrier |
| Chair and Discussion Leader: Adam Chodobski (Brown University) |
| 7:30 pm - 8:00 pm | Joanna Szmydynger-Chodobska (Brown University)
"The Choroid Plexus/CSF System in CNS Injury" |
| 8:00 pm - 8:30 pm | Gerald D. Silverberg (Stanford University)
"CSF Circulatory Dynamics in Aging and Age-related Dementias" |
| 8:30 pm - 9:30 pm | Four speakers selected from the day's posters |
| 9:30 pm | Posters, further discussion and social occasion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Crossing the Barriers: Mechanisms of Transport |
| Chair and Discussion Leader: N. Joan Abbott (King's College London) |
| 9:00 am - 9:30 am | Susan J. Vannucci (Columbia University)
"Brain Nutrient Transport: Regulation at the Blood-Brain Barrier" |
| 9:30 am - 10:00 am | William A. Banks (St. Louis University)
"Leptin Transport Across the Blood-Brain Barrier" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Ian A. Simpson (Pennsylvania State University)
"Membrane Vesicle Preparation Studies of Glucose Transporter Asymmetries" |
| 11:00 am - 11:30 am | Diana E. Dolman (King's College London)
"Ion and Water Movements at the Blood-Brain Barrier and Their Implications" |
| 11:30 am - 12:30 pm | Formal Poster Session
(Presence of poster presenters for Session 4 mandatory) |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Afternoon free for activities and discussion |
| 4:00 pm - 6:00 pm | Optional Workshop/Discussion:
"Advances in Neurovascular Unit Research: Where Do We Go From Here?" |
| Chair and Discussion Leader: Maria Spatz (NIH) |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| 7:30 pm - 9:30 pm | Crossing the Barriers: Mechanisms of Transport |
| Chair and Discussion Leader: David D. Allen (Texas Tech University) |
| 7:30 pm - 8:00 pm | Alice R.A. Villalobos (University of Rochester)
"Stress-Induced Modulation of Choline Transport by the Choroid Plexus" |
| 8:00 pm - 8:30 pm | Douglas H. Sweet (Medical University of South Carolina)
"Knockout of Organic Anion Transporter 3: Effects on Substrate Distribution within the CNS" |
| 8:30 pm - 9:30 pm | Four speakers selected from the day's posters |
| 9:30 pm | Posters, further discussion and social occasion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Delivery of Drug and Gene Therapies to the CNS |
| Chair and Discussion Leader: Andreas Reichel (Schering, Berlin, Germany) |
| 9:00 am - 9:30 am | Natalie D. Eddington (University of Maryland)
"Zona Occludins Toxin: A Delivery System That Enhances CNS Drug Penetration" |
| 9:30 am - 10:00 am | Scott M. Ocheltree (University of Michigan)
"Role of PEPT2 in the Choroid Plexus Uptake of Cefadroxil: Implications for the CNS Disposition of Peptidomimetic Drugs" |
| 10:00 am - 10:30 am | Coffee Break |
| 10:30 am - 11:00 am | Jashvant D. Unadkat (University of Washington)
"Circumventing the Transporter Blood-Brain Barrier to Enhance Drug Delivery to the CNS" |
| 11:00 am - 11:30 am | James C. Lin (University of Illinois Chicago)
"Therapeutic Applications of High Power Microwave Energy Induced Opening of the Blood-Brain Barrier" |
| 11:30 am - 12:30 pm | Formal Poster Session
(Presence of poster presenters for Session 4 mandatory) |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Afternoon free for activities and discussion |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Delivery of Drug and gene Therapies to the CNS |
| Chair and Discussion Leader: David S. Miller (NIEHS) |
| 7:30 pm - 8:00 pm | Felix Schlachetzki (University of Regensburg, Germany)
"Gene Therapy Strategies for Delivery to the Brain" |
| 8:00 pm - 8:30 pm | Damir Janigro (Cleveland Clinic)
"Overlapping Expression of MDR in Human Epileptic and Brain Tumor Tissue" |
| 8:30 pm - 9:30 pm | Four speakers selected from the day's posters |
| 9:30 pm | Posters, further discussion and social occasion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
