Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Brain Barriers in Regulation of CNS Immune Privilege
The keynotes will address novel insights on the role of brain barriers in regulating afferent and efferent connections of the immune system with the CNS.
7:40 pm - 8:15 pm
"Translational Insights into Meningeal Lymphatic Vessels"
8:15 pm - 8:30 pm
Discussion
8:30 pm - 9:05 pm
"How Autoaggressive Effector T Cells Overcome the Blood Brain Barrier"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of Brain Barriers in CNS Fluid Flow: Imaging, Modeling and Neurosurgery
9:00 am - 9:20 am
"Fluxes and Flows: The Need to Consider Them Together"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Magnetic Resonance Elastography: Interrogation of Biological Tissue Stiffness as a Noninvasive Biomarker of Pathology"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Evidence for Perivascular Astroglial Dysfunction in the Development of Human Alzheimer’s Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Computational Modeling of CNS Fluid Flow: Differentiating Fluid Flow and Solute Transport in the CNS"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Mechanisms and Consequences of BBB Disruption in Neurosurgical Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Rapid Outflow of Cerebrospinal Fluid Through Lymphatic Vessels During Waking Conditions Limits Tracer Spread to Paravascular Spaces of the Brain"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Brain Barriers in Development and Homeostasis
7:30 pm - 7:50 pm
"Molecular Basis of the Single-Cell Control Mechanism of Brain Angiogenesis and BBB Formation in Zebrafish"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Zooming in on the Choroid Plexus"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Establishment of Brain Barriers and Functional Interfaces During Human Development"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Optogenetic Control of Cerebral Microvessel Tone and Blood-Brain Barrier Permeability"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Brain Barrier Bioinformatics and Omics
This session will include introduction of a BBB expression atlas (BBBHub) making quality controlled brain barriers OMICS data available to the barriers scientific community.
9:00 am - 9:20 am
"Defining Vascular Cell Types, Subtypes and Phenotypes in the Brain Using Single Cell RNA Sequencing"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Transcriptomic of the Choroid Plexus in Multiple Sclerosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Characterisation of the Proteome of the Brain-Like Endothelial Cells (BLECs) in a Human BBB Model"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"Building the BBB CARTA: Where Molecules Meet Function"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"In Vivo Screening of Peripheral Tissues-Derived Blood-Brain Barrier Permeable Endogenous Proteins by Quantitative Comprehensive SWATH Proteomics"
11:40 am - 11:45 am
Discussion
11:45 am - 12:05 pm
"BBBHub: Blood-Brain Barriers Expression Atlas"
12:05 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Mechanisms Regulating Barrier Integrity
Session in honor of Morris J. Karnovsky .
7:30 pm - 7:50 pm
"Dose Dependent Expression of Claudin-5 Is a Modifying Factor in Neurological Disease"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Transcriptional Regulation of the Blood Brain Barrier Differentiation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Wnt/Beta-Catenin Signaling as a Therapeutic Target for Blood-Brain Barrier Repair in Neurological Disorders"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Social Stress Induces Neurovascular Pathology Promoting Depression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Role of the Brain Barriers in Tumor Growth and Brain Metastases
9:00 am - 9:20 am
"Getting Across the Blood-Brain and Blood-Tumor Barrier: Bench to Bedside Translation of Novel Chemotherapeutics"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Considerations in the Design and Use of Small Molecule Drugs for Brain Cancer"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Novel Insights into Blood-Brain Barrier Function and the Perivascular Niche in Brain Tumors: From Biology to Therapy"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Spatial Distribution of Tumor – Surgical Molecular Imaging"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Impact of Heterogeneous Drug Delivery on Treatment Efficacy in Glioma"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Effect of an Adenosine A2A Agonist on Intra-Tumoral Concentrations of Temozolomide in Patients with Recurrent Glioblastoma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Novel Concepts in Drug Delivery Across the Brain Barriers
7:30 pm - 7:50 pm
"Mechanisms Underlying the Central Delivery and Distribution of Macromolecules and Other Large Biologics: Focus on Perivascular Space Access and Transport as Key Regulators of Efficiency"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Engineering Nanoparticles to Treat CNS Injury"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Cell Mediated Drug Delivery Across the BBB"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Two-Photon Fluorescence Imaging: A Platform to Investigate Cell-Penetrating Peptides and Liposome-Based Nanocarriers for Drug Delivery Across the BBB"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
BBB Microenvironment in Health and Disease
9:00 am - 9:20 am
"The Blood Brain Barrier in Diabetes: Alterations in Ion Transporters, Channels and Intracellular [Ca]"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Neurovascular Protection by Adropin in Ischemic Stroke"
9:50 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Astrocyte Ca2+ Signaling at the Blood-Brain Barrier Across Sleep-Wake States"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"The Importance of the Glymphatic System in the Migration of Therapeutic Monoclonal Antibodies"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Involvement of Pial Vessels in Leukocyte Invasion into the CNS"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"The Contribution of the Cell Surface Adhesin BspC to Group B Streptococcal BBB Penetration and the Development of Meningitis"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"In Vivo Imaging of Targeted Exosomes in a Metastatic Brain Tumor Model"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Recent Breakthroughs in Brain Barriers Research"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Engineering the Human Brain Barriers
The trendsetting theme of bioengineering the human brain barriers will be addressed by a junior and senior closing keynote.
7:30 pm - 8:05 pm
"Human BBB-on-a-Chip for Drug Testing and the Identification of the BBB Shuttle Peptide"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:50 pm
"Stem Cell Modeling of the Neurovascular Unit"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:15 pm
General Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure