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Barriers of the CNS

Gordon Research Conference

Genetics to Physiology and Bench to Bedside

June 9 - 14, 2024

Chair

Vice Chair

Colby-Sawyer College

541 Main Street

New London, New Hampshire, United States

Venue and Travel Information

Conference Description

The Barriers of the CNS GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Early career scientists are also strongly encouraged to apply for the related GRS meeting (see below).

Related Meeting

This GRC will be held in conjunction with the "Barriers of the CNS" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Barrier Regulation and Manipulation to Treat Disease Discussion Leader:
7:40 pm - 8:20 pm	"Marker Molecules to Measure the Blood-Brain Barrier Permeability in Brain Tumor Patients"
8:20 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	"Repairing the Blood-Retinal-Barrier to Prevent Retinopathies"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Genetic Diseases and Gene Therapies Targeting BBB Biology Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Delivering Genes Across the BBB in Mice and Humans Through the Introduction of New AAV-Receptor Interactions"
9:30 am - 9:35 am	Discussion
9:35 am - 9:45 am	"Alterations to the Blood-Brain Barrier in Amyotrophic Lateral Sclerosis: Impact on CNS Drug Delivery"
9:45 am - 9:50 am	Discussion
9:50 am - 10:00 am	"A Unique Lipid-siRNA Conjugate Exhibits Robust Perivascular Transport and Widespread Silencing Activity After Delivery Into CSF"
10:00 am - 10:05 am	Discussion
10:05 am - 10:15 am	"Stop Codon Readthrough Regulates AQP4 Assembly and Neuromyelitis Optica Autoantibody Binding"
10:15 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"A New Look at an Old Question: Why Does NOTCH3 Accumulate in the CADASIL Small Vessel Disease?"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"CLDN5 Missense Mutations in Neurological Diseases"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier for Delivery of Gene Therapies to the Brain"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Human iPSC-Derived Blood-Brain Barrier Models Using Extended Endothelial Cell Culture Method for CADASIL and HTRA1-Related Small Vessel Disease"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	Poster Previews
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	In Vitro Models and Trafficking at the BBB Discussion Leaders: and
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Receptor Mediated Trafficking of Antibodies in Brain Endothelial Cells"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Human In Vitro Models to Investigate Intracellular Transport and Develop the Next-Generation of Brainshuttle^TM Molecules"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Induction of Blood-Brain Barrier Properties in Culture Models"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Response of Microfluidic Astrocyte and Pericyte Co-Culture to Oxygen-Glucose Deprivation Injury and Nanoparticles"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Blood-Brain Tumor Barrier Organoid Model for Therapeutic Delivery to Glioblastoma"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Drug Delivery to the CNS. In Memory of David Begley and Danica Stanimirovic Discussion Leaders: and
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Utilizing the Transport Vehicle to Enhance Brain Delivery and Biodistribution of Biotherapeutics"
9:35 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Delivering Antibody Drugs Across the Blood-Brain Barrier: PET Imaging for Enhanced Translation"
10:00 am - 10:05 am	Discussion
10:05 am - 10:35 am	Group Photo / Coffee Break
10:35 am - 10:55 am	"Brain Delivery of Bispecific Therapeutic Antibodies by Receptor Mediated Transcytosis"
10:55 am - 11:00 am	Discussion
11:00 am - 11:20 am	"Tissue-Engineered Disease Models of the Blood-Brain Barrier"
11:20 am - 11:25 am	Discussion
11:25 am - 11:45 am	"A Brain Delivery Platform of Known and Novel Shuttles"
11:45 am - 11:50 am	Discussion
11:50 am - 12:10 pm	"Developing Drugs for CNS Disorders: Considerations for Therapies That Cross the BBB"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Understudied Cell Types and Novel Barriers of the CNS Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"When Two Phagocytes Meet at the Border: Importance of Microglia. Retinal Pigment Epithelium Interactions"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Microglial Regulation of Vascular Structure in Health and Disease"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Choroid Plexus Regulation of Cerebrospinal Fluid-Based Signaling"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:10 pm	"Structure and Regulation of the Blood Nerve Barrier"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Danegaptide, a GAP-Junction Stabilizer in the Treatment of Diabetic Retinopathy, Which Addresses Both Vascular Permeability and Capillary Loss"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	BBB Regulation in Neurological and Neuropsychiatric Diseases Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"The Stressed Blood-Brain Barrier: From Genes to Behaviors"
9:30 am - 9:35 am	Discussion
9:35 am - 9:55 am	"Neurosurgery 101"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:50 am	"Cerebrovascular Targeted Gene Therapy Delays Neurodegeneration in Huntington's Disease Models"
10:50 am - 10:55 am	Discussion
10:55 am - 11:15 am	"Unraveling Pericyte Responses During Injury and Repair With a Focus on HIF-1"
11:15 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Mechanisms Regulating the Neurovascular-Immune Interplay in Neuropsychiatric Disorders"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Loss of Endothelial Cell Tissue-Nonspecific Alkaline Phosphatase Alters Circulating Extracellular Vesicle Profiles in Experimental Ischemic Stroke"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"What is the Role of the Blood-Brain Barrier in Glutamate Regulation and Brain Excitation?"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Neuroinflammation and Neuroinfections in BBB Regulation Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Occludin as a Regulatory Protein in HIV Neuroinfection"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Mechanisms of Blood-Brain Barrier Disruption in a Murine Model of COVID-19"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Can Microglia-Vascular Interactions Unveil Heightened Neuroinfections Susceptibility in Developing Brains?"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"Estrogen Signaling Contributes to Group B Streptococcal Disruption and Invasion of Brain Endothelial Cells"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"Exploring the Prolonged Impact of Sport-Related Repetitive Head Trauma on Blood-Brain Barrier Integrity"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Dynamic Flow and Novel Concepts in the CNS Barriers Discussion Leaders: and
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Twophoton Imaging Microscopy of Neurovascular Functions"
9:35 am - 9:40 am	Discussion
9:40 am - 10:00 am	"Neurovascular Coupling and Brief CO2 Interrogate Distinct Vascular Regulations"
10:00 am - 10:05 am	Discussion
10:05 am - 10:25 am	"Neurons or Blood Vessels as the Earliest Drivers of Neurodegeneration?"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Optical and Chemogenetic Dissection of Brain Capillary Function In Vivo"
11:20 am - 11:25 am	Discussion
11:25 am - 11:35 am	"An Aquaporin-4-mRuby3 Knock-in Reporter Mouse for In Vivo Imaging of the Barrier Properties of the Glia Limitans During Immunosurveillance and Neuroinflammation"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Regulation of Transcellular and Paracellular Permeability at the Blood Brain Barrier"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Neural Stem Cells Regulate Vascular Properties in the Adult Subventricular Zone Neurogenic Niche"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Regulating the BBB to Treat Neurological Disease Discussion Leader:
7:30 pm - 8:10 pm	"Coupling Brain Vascularization to Blood-Brain Barrier Formation Through an Organotypic Angiogenic Program"
8:10 pm - 8:30 pm	Discussion
8:30 pm - 9:10 pm	"Neuro-Immune Events at the BBB in Dementia: A Role for Bioactive Lipids?"
9:10 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute Of Neurological Disorders And Stroke of the National Institutes of Health under Award Number R13NS135631. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

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