SUNDAY |
4:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | PROTEASE ACTIVITIES IN MATRIX AND TISSUE FUNCTION |
| Welcome / Introductory Comments |
| Discussion Leader: Mina Bissell (Lawrence Berkeley National Laboratory, Berkeley) |
7:30 pm - 7:50 pm | Mina Bissell (Lawrence Berkeley National Laboratory, Berkeley) "New models for branching morphogenesis and mammary function" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:20 pm | Matthew Hoffman (NIH) "Matrix remodeling during submandibular gland branching morphogenesis" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Pepper Jo Schedin (University of Colorado) "Plasticity of the mammary gland extracellular matrix and breast
cancer progression" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | John Muschler (California Pacific Medical Center Research Institute, San Francisco) "Dystroglycan, laminin anchoring and co-receptor functions in mammary epithelial cells" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | GENETICS OF BM AND BM RECEPTORS I |
| Discussion Leader: Lynn Sakai (Oregon Health Science University, Portland) |
9:00 am - 9:20 am | Bill Wadsworth (UMDNJ, Piscataway) "C-type lectin-like domain proteins regulate UNC-6/netrin mediated axon guidance and branching in C. elegans" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Roy Zent (Vanderbilt Medical Center, TN) "Integrins and ILK in renal development" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break / Group Photo |
10:30 am - 10:50 am | Ralf Adams (Cancer Research UK, London) "Regulation of cell adhesion and motility during blood vessel morphogenesis" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Lynn Sakai (Oregon Health Science University, Portland) ) "Regulation of TGFß and BMPs by fibrillin microfibrils" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Short Talk: Michael Granato (University of Pennsylvania) "Genetic analysis of extracellular matrix signaling and modification during growth cone migration and synapse formation" |
11:50 am - 12:10 pm | Short Talk: James Kramer (Northwesetern Medical School) "Nidogen functions with multiple matrix receptors in epithelial adhesion and axon guidance, requiring its G1 and G3, but not G2, domains" |
12:10 pm - 12:30 pm | Short Talk: Lisa Fessler (University of California, Los Angeles) "Metalloprotease-ECM interactions modulate growth factor control during development" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | BASEMENT MEMBRANES IN NEURAL DEVELOPMENT AND FUNCTION |
| Discussion Leader: Peter Yurchenco (UMDNJ, Piscataway) |
5:30 pm - 5:50 pm | Bruce Patton (Oregon Health and Science University, Portland, OR) "Genetic deconstruction of basement membrane function in nerve and muscle" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Holly Colognato (Cambridge University, UK) "Survival of the stickiest: how extracellular matrix signaling influences myelination" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Markus Ruegg (Basel University, Switzerland) "Signaling involved in the formation of nerve-muscle synapses" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Peter Yurchenco (UMDNJ, Piscataway) "Modulating influence of nidogen on laminins along the neuromuscular axis" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BASEMENT MEMBRANE RECEPTORS AND SIGNALING |
| Discussion Leader: Elisabeth Georges-Labouesse (University of Strasbourg) |
9:00 am - 9:20 am | Nick Brown (Cambridge University, UK) "Linking integrins to the cytoskeleton" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Mary Beckerle (University of Utah, Salt Lake City) "Stressed out: the cellular response to mechanical cues" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Miguel del Pozo (National Center for Cardiovascular Research, Madrid, Spain) "Integrins and Caveolin-1 in Migration, Endocytosis and Cell Growth" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Elisabeth Georges-Labouesse (University of Strasbourg) "Interaction between integrins and the NIK kinase: analysis in mouse and in C. elegans" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Cord Brakebusch (Copenhagen University, Denmark) "Rho GTPase function in skin" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Short Talk: Ambra Pozzi (Vanderbilt University, TN) "Integrin α1ß1 controls reactive oxygen species synthesis by negatively regulating" |
12:15 pm - 12:30 pm | Short Talk: Lea Ritie (University of Strasbourg, INSERM U682, Strasbourg, France) "Regulation of specific genes in the intestine is provided by the laminin α5 chanins" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session I |
5:30 pm - 7:30 pm | GENETICS OF BM AND BM RECEPTORS II |
| Discussion Leader: Jeff Miner (Washington University, St. Louis) |
5:30 pm - 5:50 pm | Jeff Miner (Washington University, St. Louis) "The glomerular basement membrane and kidney function" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Olivier Lefebvre (University Louis Pasteur, Strasbourg, France) "Functional analysis of laminin α1 and α5 chains using mouse models" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Brigid Hogan (Duke University, NC) "The role of BMP signaling in embryonic lung and foregut development" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Kevin Campbell (University of Iowa) "Post-translational Processing and Dystroglycan Function" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | STRUCTURE/BIOPHYSICS OF MATRIX PROTEINS AND RECEPTORS |
| Discussion Leader: Martin Humphries (University of Manchester, UK) |
9:00 am - 9:20 am | Clair Baldock (University of Manchester) "Structural studies of fibrillin-1: from domains to microfibrils" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Ian Campbell (University of Cambridge, UK) "Integrin activation by intra- and extra-cellular ligands" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Martin Humphries (University of Manchester) "Mechanisms of integrin activation" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Mark Yeager (Scripps) "Structural biology of integrins explored by electron microscopy, image analysis and molecular modeling" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Short Talk: Aleksandra Czuchra (Max Planck Institute of Biochemistry; Martinsried, Germany) "Genetic analysis of ß1 integrin 'activation motifs' in mice" |
11:50 am - 12:10 pm | Short Talk: Erhard Hohenester (Imperial College London, UK) "Interaction of the guidance molecule Slit with cellular receptors" |
12:10 pm - 12:30 pm | Short Talk: Junichi Takagi (Osaka University, Japan) "Comparative analyses of integrin-laminin interactions using purified recombinant proteins" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
6:00 pm - 6:20 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
6:30 pm - 7:30 pm | KEYNOTE LECTURE |
| Discussion Leader: Reinhard Fässler (Max Planck Institute of Biochemistry, Martinsried) |
| Mathias Mann (Max Planck Institute of Biochemistry, Martinsried, Germany) "Technical developments and applications in mass spectrometry-based proteomics" |
8:00 pm | Dinner |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | BASEMENT MEMBRANES IN DISEASE |
| Discussion Leader: Monique Aumailley (Cologne University; Germany) |
9:00 am - 9:20 am | Peter Marinkovich (Stanford University) "The role of laminin-5 in epidermal carcinogenesis" |
9:20 am - 9:30 am | Discussion |
9:30 am - 9:50 am | Eckhard Lammert (Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany) "The vascular basement membrane in pancreatic islets" |
9:50 am - 10:00 am | Discussion |
10:00 am - 10:30 am | Coffee Break |
10:30 am - 10:50 am | Lydia Sorokin (University of Münster) "Mechanisms of leukocyte transmigration of vascular basement membranes" |
10:50 am - 11:00 am | Discussion |
11:00 am - 11:20 am | Monique Aumailley (Cologne University, Germany) "Genetic disorders of the skin BM and keratinocyte migration" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Short Talk: Leena Bruckner-Tuderman (Freiburg University, Germany) "Molecular biology and pathology of Kindlin-1" |
11:50 am - 12:10 pm | Short Talk: Su Hao Lo (University of California, Davis) "Interaction between C-terminal tensin-like protein and DLC-1: a novel binding feature of tensins' SH2 domains and its implication in prostate cancer" |
12:10 pm - 12:30 pm | Short Talk: Anjelica Gonzalez (Baylor College of Medicine, Houston, TX) "ECM interactions with neutrophil integrins regulate cell activity: An engineering approach to studying cell motility in inflammation" |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 5:30 pm | Poster Session II |
5:30 pm - 7:30 pm | PROTEOGLYCANS AND SIGNALING |
| Discussion Leader: Renato Iozzo (Thomas Jefferson University, Philadelphia) |
5:30 pm - 5:50 pm | Scott Selleck (University of Minnesota) "From synapses to vessels: Using chemical and genetic tools to explore heparan sulfate activities in tissue assembly" |
5:50 pm - 6:00 pm | Discussion |
6:00 pm - 6:20 pm | Sumana Datta (Texas A&M University) "Perlecan modulates Hedgehog signaling in brain development and prostate cancer" |
6:20 pm - 6:30 pm | Discussion |
6:30 pm - 6:50 pm | Bjorn Olsen (Harvard University) "A basement membrane view of ocular angiogenesis and retinal function" |
6:50 pm - 7:00 pm | Discussion |
7:00 pm - 7:20 pm | Renato Iozzo (Thomas Jefferson University, Philadelphia) "Regulation of tumor angiogenesis by bits and pieces of perlecan" |
7:20 pm - 7:30 pm | Discussion |
8:00 pm | Dinner |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |