Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: One Carbon Feedstocks for Biocatalysis
Discussion Leader: Joelle Pelletier (Université de Montréal, Canada)
7:40 pm - 8:15 pm
Tobias Erb (Max Planck Society, Germany)
"Re-Inventing the Operating System of Photosynthesis: Building Complex Molecules Out of Thin Air"
8:15 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
Karen Draths (Michigan State University, United States)
"New Pathways for Commodity Chemical Synthesis from Methane and Carbon Dioxide"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Improved Enzymes Through In-silico Enzyme Design and Engineering
Discussion Leader: Margit Winkler (Austrian Centre of Industrial Biotechnology and Graz University of Technology, Austria)
9:00 am - 9:25 am
Sílvia Osuna (University of Girona & ICREA, Spain)
"Computationally Designing Enzymes with Nature-Like Catalytic Efficiencies"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Birte Höcker (Universität Bayreuth, Germany)
"Enzyme Design with Generative AI Models"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Jiri Damborsky (FNUSA-ICRC & Masaryk University, Czech Republic)
"Automating Computational Enzyme Design in the Quantum Age"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
Claudia Schmidt-Dannert (University of Minnesota, United States)
"Building 3D-Assembled, Macro-Scale Protein Materials for Enzyme Immobilization and Biocatalysis"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Caroline Paul (Delft University of Technology, The Netherlands)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Applications of Biocatalysis with Natural Substrates
Discussion Leader: Rebecca Buller (Zurich University of Applied Sciences, Switzerland)
7:30 pm - 7:55 pm
Sarah Lovelock (University of Manchester, United Kingdom)
"Biocatalytic Approaches to Nucleic Acid Therapeutics Manufacturing"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Selin Kara (Aarhus University and Leibniz University Hannover, Denmark)
"Process Intensification for Biocatalytic Reactions: Transitioning from Proof-of-Concepts to Technical Scales"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Alison Narayan (University of Michigan, United States)
"Biocatalysis and Complex Molecule Synthesis"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
New to Nature Biocatalysis
Discussion Leader: Sonia Rodriguez Giordano (Facultad de Química, Universidad de la República, Udelar, Uruguay)
9:00 am - 9:25 am
Thomas Ward (University of Basel, Switzerland)
"Endowing Organometallic Catalysts with a Genetic Memory: Artificial Metalloenzymes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Cathleen Zeymer (TU Munich, Germany)
"De Novo Lanthanide Enzymes: From Protein Dynamics to Photoredox Catalysis"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Yang Yang (University of California Santa Barbara, United States)
"New Strategies for Stereoselective Radical Biocatalysis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
Rudi Fasan (University of Texas at Dallas, United States)
"Design and Engineering of Metalloenzymes for New-to-Nature Reactions"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sustainable Chemistry Through Biocatalysis
Discussion Leader: John Woodley (Technical University of Denmark, Denmark)
7:30 pm - 7:55 pm
Doerte Rother (Forschungszentrum Juelich GmbH, Germany)
"Multi Enzyme Catalysed Processes: From Regulation to Combinations with Microbial Cell Factories and Chemical Synthesis Steps"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Zhi Li (National University of Singapore, Singapore)
"Engineering New Enzymes and Cascade Biotransformations for Enantioselective Syntheses of High-Value Chemicals from Simple Substrates"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Volker Sieber (Technical University of Munich, Germany)
"Biocatalysis for Renewables Utilization"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Reactions in Biocatalysis
Discussion Leader: Selin Kara (Aarhus University and Leibniz University Hannover, Denmark)
9:00 am - 9:25 am
Rebecca Buller (Zurich University of Applied Sciences, Switzerland)
"Enzymatic Construction of DNA-Encoded Chemical Libraries"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
Jared Lewis (Indiana University, United States)
"Identifying and Engineering New Platform Enzymes for Selective Biocatalysis"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Francesca Paradisi (University of Bern, Switzerland)
"Integrated (Bio)Catalysis: Combining Strategies in Sustainable Synthesis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
Emma Master (University of Toronto, Canada)
"Enzymes to Upgrade Rather than Degrade Underused and Renewable Biomass"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Enzymes and Enzyme Engineering
Discussion Leader: Dunming Zhu (Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, China)
7:30 pm - 7:55 pm
Helen Hailes (University College London, United Kingdom)
"Mechanoenzymatic Reactions and Other Adventures"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Caroline Paul (Delft University of Technology, The Netherlands)
"Unlocking Biocatalytic Reactions through Cofactor Tuning"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Wilfred van der Donk (HHMI and the University of Illinois at Urbana-Champaign, United States)
"Genome Mining for New Macrocyclase Biocatalysts"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Biocatalysis in Industry
Discussion Leaders: Nicholas Turner (University of Manchester, United Kingdom) and Scott France (Merck & Co., United States)
9:00 am - 9:15 am
Martin Hayes (AstraZeneca R&D, Sweden)
"The Value of Collaboration in Biocatalytic Drug Discovery"
9:15 am - 9:25 am
Discussion
9:25 am - 9:40 am
Stefan Lutz (Codexis Inc., United States)
"Oligonucleotide Manufacturing Using Engineered Enzymes"
9:40 am - 9:50 am
Discussion
9:50 am - 10:05 am
Matthew Thompson (Biomatter , Sweden)
"Reimagine Enzymes: Blending Physics with Generative AI"
10:05 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
Kai Baldenius (Baldenius Biotech Consulting, Germany)
"Industrial Biocatalysis: Performance Indicators for Quick Cost Estimates"
11:00 am - 11:10 am
Discussion
11:10 am - 11:25 am
Hans Iding (Hoffmann-La Roche AG, Switzerland)
"Engineered (S)-Transaminase Applied in an Organic Solvent"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
Richard Fox (Inscripta, United States)
"Rapid Enzyme, Pathway, and Genome Scale Engineering for Whole-Cell Biocatalysis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
Lara Zetzsche (Amgen, United States)
"Early Biocatalysis Strategies with the End in Mind"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanistic Understanding in Biocatalytic Systems
Discussion Leader: Bettina Nestl (Innophore GmbH, Austria)
7:30 pm - 7:55 pm
Mélanie Hall (University of Graz, Austria)
"Repurposing Enzymes for Non-Natural Reactions"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
Gideon Grogan (University of York, United Kingdom)
"Synthesis of Amide Pharmaceuticals Using Amide Bond Synthetases"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Bernhard Hauer (University of Stuttgart, Germany)
"Beyond Nature: Enzymes for Challenging Applications"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure