Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Reflecting on Three Decades of Advancements in the Life Sciences that Shaped Modern Biocatalysis
7:40 pm - 8:15 pm
"Past and Present Opportunities and Challenges in Biocatalysis: Enzyme Discovery, Engineering, and Emerging Applications for Organic Synthesis and Beyond"
8:15 pm - 8:35 pm
Discussion
8:35 pm - 9:10 pm
"Designing Enzymes via Ancestral Sequence reconstruction and Rational Engineering"
9:10 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Solving Chemistry Challenges with Novel Reactions
9:00 am - 9:25 am
"Discovering and Reprogramming Nitrogen–Nitrogen Bond-Forming Enzymes to Expand Catalytic Space for Sustainable Pharmaceutical Synthesis"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Enzyme and Reaction Engineering for the Highly Diastereoselective Synthesis of Trans-3-Amino-2,2,4,4-Tetramethylcyclobutanol"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Opportunities for Merging Biosynthesis and Biocatalysis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Biocatalytic Synthesis of Enlicitide"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Blending Wet-Lab and Computation to Leverage Enzyme Catalysis
7:30 pm - 7:55 pm
"Long-Range Radical Transport in Ribonucleotide Reductase"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"The Design of Stable and Efficient Peroxygenase Biocatalyts for Selective Oxidations"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"The Enzymes Dance: From Experimental Visualization of Reactivity to AI Predictions"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
De Novo Enzyme Design: The Hype, the Hope and Real-World Impact
9:00 am - 9:25 am
"A Hybrid Machine Learning and Atomistic Modeling Approach for the Design of De Novo Enzymes"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Building Catalysis from Scratch: Scaffold Customization and Multistate Reaction Optimization in De Novo Enzyme Design"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Evolution and Benchmarking of Enzymes for Sustainable Catalysis"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Multi-Parameter Enzyme Optimization Through Informed Navigation in Combinatorial Sequence Space"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Designing the Next Generation of Biocatalysts
7:30 pm - 7:55 pm
"Expanding the Engineering of Unspecific Peroxygenases"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Engineering Redox Catalysis in Biology"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Designing Oxygen-Driven Cascades in Bacteria Engineered for Limited Reduction"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Accelerating Biocatalysis Through Technology
9:00 am - 9:25 am
"Data-Rich Protein Discovery and Engineering"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Mechanistic Backups, Conformational Flexibility and Oxidative Regulation: Exploring the Unusual World of Archaeal Phosphatases"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Prototyping Multifunctional Heterogeneous Biocatalyst for Cell-Free Biosynthetic Pathways"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"CatalophoreTM-Guided Discovery of Stable and Efficient IREDs for Biocatalysis"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Synthetic Biology Without Limits
7:30 pm - 7:55 pm
"Microbial Metabolites for Biocompatible Chemistry"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Decoding Plant Hormone Function from Biosynthesis"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Pushing the Limits of Predictability in Synthetic Biology"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Exploring Nature’s Hidden Catalysts
9:00 am - 9:25 am
"Enzymatic Reactions in Natural Product Biosynthesis"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Discovery and Application of Biocatalysts and Biosynthetic Products from Ocean Life"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Decoding the Molecular Logic of Biocatalytic N–N Bond Formation"
11:15 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Recent Insights into the Activity, Oxidative Stability and Diversity of LPMOs, Ubiquitous Mono-Copper Enzymes Performing Amazing Chemistry"
11:55 am - 12:10 pm
Discussion
12:10 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Investigators in the Interdisciplinary Field of Biocatalysis
7:30 pm - 7:50 pm
"Repurposing Thiamine-Dependent Enzymes with Radicals"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Biocatalytic Heterocycle Synthesis Enabled by Vanadium-Dependent Haloperoxidase Enzymes"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Chemoenzymatic Synthesis of Backbone-Modified Peptides Using Natural Product Biosynthetic Enzymes"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure