SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | V-ATPases: Structure, Function and Disease |
| Discussion Leader: Karlett Parra (University of New Mexico) |
7:55 pm - 8:15 pm | Wilson Lau (University of Toronto)
"Cryo-EM structure of the V-ATPase from Thermus thermophilus" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Michael Forgac (Tufts University)
"Regulation of V-ATPase Assembly" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Sylvie Breton (Harvard University)
"Regulation of V-ATPase Recycling in Proton Secreting Mammalian Cells" |
9:25 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Complex I: Structure-Function and Dysfunction |
| Discussion Leader: Judy Hirst (Medical Research Council) |
9:20 am - 9:50 am | Leonid Sazanov (Medical Research Council)
"Architecture and Mechanism of Bacterial Complex I" |
9:50 am - 10:00 am | Discussion |
10:00 am | Group Photo / Coffee Break |
10:40 am - 11:05 am | Volker Zickermann (Goethe Universität)
"Structural Basis for Redox-Linked Proton Translocation by Mitochondrial Complex I" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:40 am | Manuela Pereira (Universidade de Nova Lisboa)
"Sodium Influence on the Energy Transduction from Prokaryotic Complexes I" |
11:40 am - 11:50 am | Discussion |
11:50 am - 12:15 pm | Blanca Barquera (Rensselaer Polytechnic Institute)
"Na+-NQR a Unique Redox-Driven Ion Pump" |
12:15 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Mitochondrial Dysfunction and Aging |
| Discussion Leader: Eric Schon (Columbia University) |
7:50 pm - 8:15 pm | Christiaan Leeuwenburgh (University of Florida)
"Central Role for Mitochondria in Aging" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Rodrigue Rossignol (Universite Victor Segalen-Bordeaux)
"Choosing between Glycolysis and Oxidative Phosphorylation: A tumor's Dilemma?" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Lesley Kane (National Institues of Health)
"Parkin-Mediated Autophagy of Mitochondria with Impaired Function" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Advances in Complexes II and III |
| Discussion Leader: Chang-An Yu (Oklahoma State University) |
9:20 am - 9:50 am | Gary Cecchini (VAMC San Francisco, UCSF)
"The Iron-Sulfur, Quinone, Heme Axis of Complex II" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Pascal Lanciano (University of Pennsylvania)
"Inter-monomer Electron Transfer Between the Low Potential b Hemes of Cytochrome bc1" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Colin Wraight (University of Illinois)
"Alternate Reactions of Cytochrome c1" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Egbert Boekema (University of Groningen)
"Three-Dimensional Structures from Mitochondrial Supercomplexes by Electron Microscopy and Tomography" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Complex IV and Regulation of Respiration |
| Discussion Leader: Robert Gennis (University of Illinois) |
7:50 pm - 8:15 pm | Shelagh Ferguson-Miller (Michigan State University)
"Crystallographic Evidence of Conformational Change and Ligand Binding as Regulators of Cytochrome c Oxidase" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Susanne Arnold (Aachen University)
"Regulation of Cytochrome c Oxidase and its impact on Neural Cell Signal Transduction and Survival" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Ulrich Hammerling (Sloan Kettering Cancer Institute)
"Regulation of Energy Homeostasis by the Intra-Mitochondrial PKC Delta Signaling Pathway" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Spins and Stalks |
| Discussion Leader: Steven Vik (Southern Methodist University) |
9:20 am - 9:50 am | Hiroyuki Noji (Tokyo University)
"Rotation of F1 Without the Rotor" |
9:50 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 10:55 am | Wayne Frasch (Arizona State University)
"Exercising Restraint - Load Dependent Stepping of the Fo Motor" |
10:55 am - 11:05 am | Discussion |
11:05 am - 11:30 am | Thomas Meier (Max Planck Institute of Biophysics)
"Rotors and Ions in ATP synthases: Functional Adaptations of the Fo Complex to the Rotary Mechanism" |
11:30 am - 11:40 am | Discussion |
11:40 am - 12:05 pm | Daniela Stock (Victor Chang Cardiac Research Institute)
"The Peripheral Stalks of A-type ATPases" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Mitochondria in the Cell |
| Discussion Leader: David Nicholls (Buck Institute) |
7:45 pm - 8:10 pm | Toren Finkel (National Institutes of Health)
"Metabolic and bioenergetic aspects of cellular senescence" |
8:10 pm - 8:20 pm | Discussion |
8:20 pm - 8:45 pm | Carlos Moraes (University of Miami)
"Increased Mitochondrial Biogenesis is Beneficial to OXPHOS-Impaired Cells" |
8:45 pm - 8:55 pm | Discussion |
8:55 pm - 9:20 pm | Orian Shirihai (Boston University)
"Linking Mitochondrial Dynamics to Bioenergetics" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Posters Oral Discussion Session |
| Discussion Leaders: Ulrich Brandt (Goethe Universität) and Shannon Holliday (University of Florida) |
9:00 am - 10:00 am | TBA (Selected Poster Presenters and Discussion) |
10:00 am | Coffee Break |
10:30 am - 12:00 pm | TBA (Selected Poster Presenters and Discussion) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Structural Biology of ATP Synthase |
| Discussion Leader: Stanley Dunn (University of Western Ontario) |
7:50 pm - 8:15 pm | David Mueller (Rosalind Franklin University)
"Understanding Structure, Function, and Mutations in the Mitochondrial ATP Synthase" |
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 9:20 pm | John Walker (Medical Research Council)
"Structure, Mechanism and Regulation of F-ATPases" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |