SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Mechanisms and Energetics of ATP-Synthesis |
| Discussion Leader: Wayne Frasch (Arizona State University) |
7:55 pm - 8:40 pm | John Walker (MRC Mitochondrial Biology Unit)
"Bioenergetics research over the past 50 years: what next?"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | David Mueller (Rosalind Franklin University)
"The structural basis of drug binding and disease as related to the mitochondrial ATP synthase"
|
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Structure and Function of Complex I |
| Discussion Leader: Thorsten Friedrich (University of Freiburg) |
9:20 am - 9:45 am | Leonid Sazanov (MRC Mitochondrial Biology Unit)
"Structure and mechanism of complex I"
|
9:45 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Volker Zickermann (Goethe-University)
"The structure of mitochondrial complex I"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
10:55 am - 11:20 am | Hideto Miyoshi (Kyoto University)
"Identification of the binding site of amilorides, inhibitors of proton-pumping machinery of complex I"
|
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Judy Hirst (MRC Mitochondrial Biology Unit)
"Inhibition of complex I"
|
11:45 am - 11:50 am | Discussion |
11:50 am - 12:05 pm | Oscar Juarez (Rensselaer Polytechnic Institute)
"Aspartate 397 in subunit B of Vibrio cholerae Na+-NQR forms part of the sodium binding site, is involved in cation selectivity and affect cation binding site cooperativity"
|
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Margareta Blomberg (Stockholm University)
"Energetic requirements for proton pumping in heme-copper oxidases - a theoretical study"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Diversity of Bioenergetic Systems |
| Discussion Leader: Manuela Pereira (University of Lisbon) |
7:50 pm - 8:15 pm | Rolf Thauer (MPI for Terrestric Microbiology)
"Flavin-based electron bifurcation in anaerobic bacteria and archaea: a novel mechanism of energy coupling"
|
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Pia Ädelroth (University of Stockholm)
"Proton transfer in the diverse members of the heme-copper oxidase superfamily"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Anthony Moore (University of Sussex)
"Structure and function of the alternative oxidases in plants and human pathogens"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Emerging Techniques |
| Discussion Leader: Les Dutton (University of Pennsylvania) |
9:10 am - 9:50 am | Les Dutton (University of Pennsylvania)
"In Memory of Britton Chance: An electrical engineers approach to bioenergetics from quantum mechanics to quantitative diagnostics"
|
9:50 am - 10:00 am | Discussion |
10:00 am - 10:25 am | Petra Fromme (Arizona State University)
"Time resolved femtosecond nanocrystallography opens a new era in structural biology"
|
10:25 am - 10:35 am | Discussion |
10:35 am | Coffee Break |
11:00 am - 11:25 am | Manuela Zoonens (CNRS Paris)
"Amphipols: versatile tools to stabilize and study membrane proteins in aqueous solutions"
|
11:25 am - 11:35 am | Discussion |
11:35 am - 12:00 pm | Michael Börsch (Friedrich Schiller University Jena)
"Monitoring conformational changes in individual FoF1-ATP synthases by advanced single-molecule FRET imaging in solution"
|
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Roger Springett (Dartmouth College)
"Quantitation of the mitochondrial membrane potential and pH gradient in living cells"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Respiratory Complexes in Health and Disease |
| Discussion Leader: Gary Cecchini (San Francisco VA Medical Center) |
7:50 pm - 8:15 pm | Artur Osyczka (Jagiellonian University)
"A new perspective on the mechanism of quinol oxidation catalyzed by the cytochrome bc1 complex"
|
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Peter R. Rich (University College London)
"Functions of the hydrophilic channels in mitochondrial cytochrome c oxidase"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Ólöf Einarsdóttir (University of California)
"Protein tuning of ligand pathways and metal centers in heme-copper oxidases"
|
9:25 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mechanisms and Functions of V-type and A-type ATPases |
| Discussion Leader: Volker Müller (Goethe-University Frankfurt) |
9:20 am - 9:45 am | Patricia Kane (SUNY Upstate Medical University)
"Multiple modes of V-ATPase regulation"
|
9:45 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Gerhard Grüber (Nanyang Technological University)
"Structural and mechanistic diversities and similarities of the coupling domains in A-ATP synthases and eukaryotic V-ATPases"
|
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:25 am | Dennis Brown (Massachusetts General Hospital)
"Regulation of the V-ATPase in proton secreting epithelial cells"
|
11:25 am - 11:35 am | Discussion |
11:35 am - 11:50 am | Takeshi Murata (Chiba University)
"Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures" |
11:50 am - 11:55 am | Discussion |
11:55 am - 12:10 pm | Laura Preiss (Max Planck Institute for Biophysics)
"Life in a proton desert: Adaptations of the Bacillus pseudofirmus OF4 ATP synthase rotor ring"
|
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Supramolecular Organization of Bioenergetic Complexes |
| Discussion Leader: Rosemary Stuart (Marquette University) |
7:50 pm - 8:15 pm | Cristina Ugalde (University Hospital Madrid)
"Assembly of mitochondrial respirasomes in human cellular models in health and disease"
|
8:15 pm - 8:25 pm | Discussion |
8:25 pm - 8:50 pm | Antonio Enriquez (Centro Nacional de Investigaciones Cardiovasculares)
"Functional role of respiratory supercomplexes"
|
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:25 pm | Charles L. Hoppel (Case Western Reserve University)
"Respiratory supercomplexes in disease" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Poster Oral Discussion Session |
| Discussion Leaders: Karlett Parra (University of New Mexico) and Susanne Arnold (Nijmegen Center for Mitochondrial Disorders) |
9:00 am - 10:15 am | TBA (Selected from Poster Presentations) |
10:15 am | Coffee Break |
10:45 am - 12:15 pm | TBA (Selected from Poster Presentations) |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Systems Biology and Mitochondrial Diseases |
| Discussion Leader: Jan Smeitink (Nijmegen Center for Mitochondrial Disorders) |
7:55 pm - 8:20 pm | Salvatore DiMauro (Columbia University)
"Mitochondrial medicine"
|
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:55 pm | Massimo Zeviani (National Institute of Neurology)
"Networking proteins and mechanisms by studying mitochondrial disease"
|
8:55 pm - 9:05 pm | Discussion |
9:05 pm - 9:20 pm | Marleen Forkink (Radboud University Nijmegen Medical Center)
"Mitochondrial hyperpolarization during complex I inhibition requires active ETC complexes and modulates calcium signaling"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |