Thursday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Metals, Water, Light, O2 , Camera and Action!
Joint session with the Metals in Biology Gordon Research Conference.
7:30 pm - 7:40 pm
"Unraveling the Role of Local and Global Protein Properties on the Redox Behavior of Tryptophan and Tyrosine"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Trapping Intermediates in Metal Transfer Reactions of the CusCBAF Export Pump of E. coli "
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Taking Snapshots of the Water Oxidation Reaction in Photosystem II Using Crystallography and Spectroscopy at an XFEL"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 9:15 pm
"Progress Towards a Molecular Mechanism of Water Oxidation in Photosystem II"
9:15 pm - 9:30 pm
Discussion
9:30 pm - 11:00 pm
Poster Session
Joint Poster Session with the Metals in Biology GRC
Friday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Spectroscopic Methods to Study Metal Reactivity and the Flow of Electrons in the Cell
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Nitric Oxide Modulates DNA Repair Enzyme Conformation and DNA-Bound Redox Activity Through Nitrosylation of a [Fe4 S4 ] Cluster"
9:35 am - 9:40 am
Discussion
9:40 am - 10:00 am
"A Mechanistic View of Cytochrome c Nitrite Reductase (ccNiR)-Catalyzed Reduction of Nitrite to Nitric Oxide"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Influences of the Heme-Lysine Crosslink in Cytochrome P460 over Redox Catalysis and Nitric Oxide Sensitivity"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Shedding Light on Conformational Dynamics in Ribonucleotide Reductase"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Investigations of Nitroxyl (NO-/HNO) Reactivity at Mononuclear Nonheme Iron"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Tuning the Proton-Coupled Electron-Transfer Reactivity of Mn(III)-OH Complexes via Ligand Perturbations and Addition of Lewis Acids"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Tools for Bioinorganic Chemistry
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 7:55 pm
"1H and 13C NMR of Azide-Inhibited IsdG Reveals Spin Density Delocalization"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Genomics-Based Expansion of a Natural Combinatoric Library of Siderophores"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:40 pm
"Synthesis and Spectroscopic Characterization of Nonheme Iron Dioxygenases and Reactive Intermediates"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Exploring the Role of the Third Active Site Metal Ion in DNA Polymerase Eta with Quantum Mechanical/Molecular Mechanical Free Energy Simulations"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"O2 Activation at a Non-Heme Iron Center: A Kinetic and Spectroscopic Investigation of Catalytic C-H Bond Oxidation"
9:25 pm - 9:30 pm
Discussion
Saturday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inspired by Nature: Designing Metalloproteins and Inorganic Catalysts
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Site-Differentiated, High Spin Tetranuclear Iron Clusters that Reversibly Bind CO in Four Redox States"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cytochrome c-Mediated Chiral Organoborane Synthesis via Iron-Heme-Carbene Insertion into B-H Bonds"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Design of Mononuclear Non-Heme Enzyme for Oxygen Activation"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Influences of Structural Perturbations on Hydrogen Atom Transfer Reactivity by Oxomanganese(IV) Complexes"
11:25 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Engineering Heteronuclear Metal Centers from Iron-Sulfur and Heme-Copper Sulfite Reductases in Cytochrome c Peroxidase"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:25 pm
"FeFe Hydrogenase Biorod Conjugate by Electrochemistry and Transient Absorption"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Evaluation Period
Fill in GRS Evaluation Forms
7:30 pm - 9:30 pm
Metal Homeostasis: Moving Metals into, out of, and Around the Cell
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
"Identifying Protein-Protein Interactions Required for Iron-Sulfur Cluster Protein Recognition"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Rhodococcus ruber GIN-1 Titanium Incorporation via Cell-Oxide Interactions"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Prevention and Treatment of Internal Gadolinium Contamination from MRI Contrast Agents"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Cu(II) Selective Cell-Permeable Chelators Relieve Metal-Overload Induced Oxidative Stress"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Characterisation of Metal-Ligand Interactions and the Effect of Metal Ions on the Gene Expression of Amyloid Precursor Protein"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structure-Function Relationships in Bioinorganic Chemistry
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Role of Metal Ions in Calcium Sensing Receptor (CaSR) Mediated Extracellular Signaling"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"A Novel Copper Center in an Uncharacterized Protein from Methanotrophs"
10:00 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Characterization of a Complete Nitric Oxide Synthase from Synechococcus "
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Redox-Dependent Metal Migration in the Ni-Fe-S Cluster of Carbon Monoxide Dehydrogenase"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Crystallographic Studies of a Silicon-Carbon Bond-Forming Enzyme"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Linking Specific Macromolecular Motions to Enzyme Rate Acceleration in the TIM Barrel Superfamily of Proteins"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm
Departure