Thursday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Free Radical and Organometallic Enzyme Chemistry
7:30 pm - 7:50 pm
"Fe4 S4 Clusters Featuring a Reactive Fe Site: Preparation of Alkyl Complexes Relevant to Radical-SAM Enzymes"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"From Interferon-Stimulated to a New Antiviral: The Story of Viperin"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:15 pm
"New Insight into Cobalamin-Dependent Methylation"
9:15 pm - 9:30 pm
Discussion
9:30 pm - 11:00 pm
Poster Session
Joint Poster Session with the Metals in Biology GRC
Friday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Using the Bioinorganic Toolbox: New Methods and Techniques to Understand the Role of Metals in Nature
9:00 am - 9:20 am
"Electrochemical Hydrogen Evolution Catalyzed by CoMP11-Ac: Who Is the Substrate?"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Structural Basis for Superoxide Activation of Class Id Ribonucleotide Reductases"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Determining the Effects of Heme Pocket Residues on the Signal Transduction Within Globin Coupled Sensors"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Biological Methane Oxidation Is Catalyzed by a Mononuclear Copper Center"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"The Curious Case of ReverbĪ²: Chemical Reaction Coupling of Electron Transfer Makes Ferric Heme a Gas Sensor"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Substrate Analogue Reactivity in HydG: Radical Counterparts of Relevant Intermediates"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Applications of Metals in Biology: Biological Materials, Biomineralization, Therapeutics and Imaging
7:30 pm - 7:45 pm
"Repeat Proteins as Versatile Scaffolds for Arrays of Redox-Active Fe-S Clusters"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Designed Artificial Iron Proteins"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Enzyme-Catalyzed CdSe Quantum Dot Growth and Functionalization"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Chemoselective Cyclopropanation over Carbene Y-H Insertion Catalyzed by an Engineered Carbene Transferase"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Spin Dynamics of Coordination Complexes and Materials as Model Systems for Biology"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Repurposing Cytochrome P450s for Selective C(sp3)-H Perfluoroalkylation Using Directed Evolution"
9:25 pm - 9:30 pm
Discussion
Saturday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inspired by Nature: Understanding the Role of Metals and Structure-Function Relationships in Catalysis
9:00 am - 9:20 am
"A Four-Coordinate {CuNO}10 by Nitrite Reduction and Implications for Oxidative Stress"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Utilizing Metal Reducing Enzymes as Tags in Optical and Electron Microscopy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Structures, Spectroscopic Properties and Dioxygen Reactivity of 5- and 6-Coordinate Nonheme Iron(II) Complexes: A Combined Enzyme/Model Study of Thiol Dioxygenases"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"PQQ Biosynthesis Is Resolved by the Discovery of Unprecedented Functions for the Enzyme PqqB"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Insight into the E1 State of Mo Nitrogenase"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Understanding Ferryl Basicity in a Histidine-Ligated Peroxidase"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Evaluation Period
Fill in GRS Evaluation Forms
7:30 pm - 9:30 pm
Metals on the Move: Sequestration, Affinity and Transport of Metals in and out of the Cell
7:30 pm - 7:45 pm
"Cu+-Specific CopB Transporter: Revisiting CopA and CopB Classification"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Molecular Basis of Multiple Mitochondrial Dysfunctions Syndrome 2 (MMDS2): Impact of a Disease Causing Ile67Asn Mutation on BOLA3"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Towards the Mechanisms of Copper Insertion in Plant Cytocrome c Oxidase"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Investigating the Dependence of Proinsulin C-Peptide on Metal Micronutrients"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Genetically Encoded Fluorescent Biosensors for Probing Cellular Chloride"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Coordination Chemistry and Photoreactivity of Pacifibactin, a Marine Siderophore Identified Through Genome Mining"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Origins of Life: The Role of Metals in Evolution, Early Metabolism and Biogeochemical Cycles
9:00 am - 9:20 am
"Conformational Flexibility of Carbon Monoxide Dehydrogenase/Acetyl-CoA Synthase Revealed by Electron Microscopy"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Unraveling the Interactions of the Physiological Reductant Flavodoxin with the Different Conformations of the Fe Protein in the Nitrogenase Cycle"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Characterization of the Metalloproteome of the Marine Bacteria, Alteromonas "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Functional and Spectroscopic Investigations of CODH-I from Carboxydothermus hydrogenoformans "
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Flipping the Anaerobic Switch: [4Fe-4S] Cluster Mediated Oxygen Sensing and Global Transcription Regulation by FNR"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Conservation of Leu1's C-Terminus Is Essential for Its Recognition by the Cytosolic Iron-Sulfur Cluster Assembly Targeting Complex"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm
Departure