Thursday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Embracing Complexity in Biological Metal Ion Interactions
7:30 pm - 7:45 pm
"Unraveling the Bioinorganic Chemistry of the Extracellular Space"
7:45 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Selective Recognition of Lanthanides in Biology"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:25 pm
Introduction by Discussion Leader
8:25 pm - 9:10 pm
"The Surprising Inorganic Chemistry of the Radical SAM Enzymes"
9:10 pm - 9:30 pm
Discussion
9:30 pm - 11:00 pm
Poster Session
Joint Poster Session with the Metals in Biology GRC
Friday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nature's Building Blocks: How Metalloenzymes Construct Biomolecules
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Restoring Activity to Oxygen-Damaged Glycyl Radical Enzymes: Spare Parts for Proteins"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Exploring the Iron-Sulfur Proteome with Chemical Proteomics: From Iron-Sulfur-Dependent Pathways to Novel Metalloproteins"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Differential Ligand-Selective Control of Opposing c-di-GMP Metabolic Domains by an Unusually High Potential Heme Sensor Domain"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Methanobactin Biosynthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Predicting Zinc Binding from Structure and Sequence"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"PvfB Is a Diiron N-Oxygenase in the Biosynthesis of the Pseudomonas Virulence Factor"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Rieske Non-Heme Oxygenases in Paralytic Shellfish Toxin Biosynthesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Spectroscopic and Computational Insights into Metallobiochemistry
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Investigation of Redox Processes in Copper-Induced Aggregation of Human Eye Lens Proteins by a Combination of X-Ray Spectroscopy and Site-Directed Mutagenesis"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Selenocysteine Substition of Substrate Cysteine Residues as an X-Ray Spectroscopic Probe"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Elucidating the Role of the Axial Cysteine Residue in NHase Catalysis and the Enzyme Maturation"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Elucidating the Geometric and Electronic Structures of Assembly Intermediates in Mn/Fe R2lox Using a Multifrequency, Pulsed EPR Approach"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Evidence for Modulation of Oxygen Rebound Rate in Control of Outcome by Iron(II)- and 2-Oxoglutarate-Dependent Oxygenases"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Multi-Method Modeling for Metalloenzymes: QM/DMD and Other Computational Tools"
9:25 pm - 9:30 pm
Discussion
Saturday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metal Homeostasis: Finding the Balance of Metals in Biology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Photoswitchable Probes to Reversibly Control the Activity of Carbonic Anhydrase in Cancer Cells"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Principles of Metal Selectivity in Human Metallothionein Metal-Thiolate Clusters"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Influence of Epigallocatechin Gallate Stabilized Gold Nanoparticles in Amyloid Beta Fibril Inhibition"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Of Mice and Microbes: The Gut Microbiome Has Long-Lived Responses to Iron Deprivation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Development of Fluorescent Probes for New Delhi Metallo-Beta-Lactamase to Explore Bacterial Zinc Homeostasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Iron in NiaR: A Regulator of NAD Biosynthesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Investigating the Roles of Zinc Fingers and H2 S in Modulating the NF-κB Inflammatory Pathway"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Evaluation Period
Fill in GRS Evaluation Forms
7:30 pm - 9:30 pm
Lessons from Nature: Artificial Metal Proteins and Biomimetic Inorganic Complexes
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:50 pm
"Comparative Reactivity of Thiolates and Nitric Oxide with Non-Heme Diiron(II) Complexes"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Site-Specific Labeling of Nitrogenase Cofactors"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"The Exciting Potential of Ruthenium Complexes as Controllable Hydrogen Sulfide Donors"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"De Novo Design of Functional Metalloporphyrin-Containing Proteins"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"Expanding the Accessibility of 3D-Space in Medicinal Chemistry: Metallofragments as 3D Scaffolds for Fragment-Based Drug Discovery"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Switchable Artificial Metalloproteins to Probe Conformational Control in Enzyme Function"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Reactive Metal Species in Small Molecule Activation and Biocatalysis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"The Multifunctional Globin Dehaloperoxidase Strikes Again: Simultaneous Peroxidase and Peroxygenase Mechanisms in the Oxidation of EPA Pollutants"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"New Strategies for Ribonucleotide Reduction in Metal Restricted Environments"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"Anaerobic Heme Degradation in Pathogenic E. coli "
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Structural and Spectroscopic Investigation of Cysteamine Dioxygenase"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"TriCyt3: A Novel Protein Scaffold for Investigating Fundamental Mechanisms of Metalloprotein Function"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Bacterial Defense Against Oxidative and Nitrosative Stress: Spectroscopic Study of Hemerythrin-Like Proteins from Mycobacterium tuberculosis and Mycobacterium kansasii "
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm
Departure