Friday
12:00 pm - 4:00 pm
Arrival and Check-in
2:30 pm - 4:00 pm
Poster Session
4:00 pm - 4:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
4:15 pm - 6:00 pm
Elemental Living: Daily Experiences with Metals in Biology, Environment and Medicine
4:15 pm - 4:20 pm
Introduction by Discussion Leader
4:20 pm - 4:35 pm
"Investigating the Metal Ion Binding of Vimentin Tail Domain Fragments"
4:35 pm - 4:40 pm
Discussion
4:40 pm - 4:55 pm
"Redox Reactivities of Membrane-Bound Amyloid-ß-Cu Complexes and their Targeting by Metallothionein-3 "
4:55 pm - 5:00 pm
Discussion
5:00 pm - 5:15 pm
"Oxygen Affinities of DosT and DosS Sensor Kinases with Implications for Hypoxia Adaptation in Mycobacterium tuberculosis "
5:15 pm - 5:20 pm
Discussion
5:20 pm - 5:35 pm
"Extrinsic and Intrinsic Properties Affecting Cu-Induced Protein Precipitation Across Eukaryotic and Prokaryotic Proteomes"
5:35 pm - 5:40 pm
Discussion
5:40 pm - 5:55 pm
"Exploring Metal Ion Redistribution and Signaling Pathways in Zinc Deficiency-Induced Quiescence"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Metals at the Crossroads: Synthetic Inorganic Chemistry as a Biological Explorer
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Copper-Promoted Hydroxylation of C-H Bonds Using Bidentate Imine Directing Group 2-(2-aminoethyl)pyridine and H2 O2 as Oxidant"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"Reactivity Study of Thiolate Ligated Zn(II) Complexes with Dioxygen and Hydrogen Sulfide: Synthetic Insights into Zinc Finger Persulfidation"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Stabilization Effect of NH-S Hydrogen Bonds in Synthetic Iron-Sulfur and Iron-Selenium Clusters"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Thermodynamics of Proton-Coupled Electron Transfer at Tricopper µ-Oxo, Hydroxo and Aqua Complexes"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Small Molecule Activation at Low-Valent Fe₃ (Poly)hydrides"
9:25 pm - 9:30 pm
Discussion
Saturday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Bridging Nature and Invention: The Biocatalysis and Artificial Metalloenzyme Nexus
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Engineer Heme-Dependent Enzymes for C–N Bond Construction"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"An Anchoring Group Strategy for the Enzymatic Halogenation of Complex Natural Products"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Structure-Driven Development of a PQQ Containing Artificial Metalloenzyme"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
"Design of Artificial FeMoco-Binding Proteins Capable of Small Molecule Activation"
11:00 am - 11:05 am
Discussion
11:05 am - 11:20 am
"Deciphering the Reaction Mechanism and Improving the Catalytic Activity of the Lanthanum and Pyrroloquinoline Quinone-Dependent Artificial Metalloenzyme"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Radical Photocatalytic Oxidative Hydroaminations and Alkylations in Evolved Enzymes and Molybdenum Doping Enhances Back bonding at Neighboring Iron Centers in Iron-Sulfur Clusters"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"B12 -Dependent Enzymes: A New Platform for Non-Native Biocatalysis"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Enhanced Rare Earth Element Detection and Separation Using Novel Lanmodulin Orthologs"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:15 pm - 6:00 pm
Navigating Metal Dynamics: Homeostasis and Regulation in the Biological Landscape
4:15 pm - 4:20 pm
Introduction by Discussion Leader
4:20 pm - 4:35 pm
"Using Fluorescent Protein-Based Zn2+ Sensors to Investigate Zinc Uptake and Regulation in Bacteria"
4:35 pm - 4:40 pm
Discussion
4:40 pm - 4:55 pm
"The Escherichia Coli AZY Operon Links Copper Uptake to Antibiotic Resistance"
4:55 pm - 5:00 pm
Discussion
5:00 pm - 5:15 pm
"Optochemical Control of Cu(I) Homeostasis in Mammalian Cells"
5:15 pm - 5:20 pm
Discussion
5:20 pm - 5:35 pm
"Discovery, Characterization, and Biosynthesis of C-Type Diazeniumdiolate Siderophores"
5:35 pm - 5:40 pm
Discussion
5:40 pm - 5:55 pm
"Investigating CuZnSod1’s Role in Copper Homeostasis Mechanisms in Candida Albicans"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
7:30 pm - 9:30 pm
The Trifecta Toolbox: Structural, Spectroscopic, and Computational Techniques in Bioinorganic Chemistry
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Kinetic Profile of the Iron and 2-Oxoglutarate-Dependent Enzyme DfmD Implicates a Unique Mechanism"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:15 pm
"No Bridge Between Us: Computational Investigations of the Active Site Structure of Alkane Monoxygenase B"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:35 pm
"Unique Redox Properties of [4Fe-4S] Clusters in Flavin Based Electron Bifurcation"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
"Unambiguous Assignment of Reduction Potentials to a Multi-Heme ‘Nanowire’ Predicts Physiological Redox Conductivity"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
"Increased Conformational Dynamics Slow Down Electron Transfer in Lys-Ligated Cytochrome c"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Choreography: Mechanistic Insights into Metalloenzyme Catalysis
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Enzymatic Polyhalogenation of Inert C-H Bonds: From Fundamental Insights into Chemo-Selective Radical Rebound in Non-Heme Fe Halogenases to Applications in Biocatalysis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Methylthio-Alkane Reductases Rely on Nitrogenase Clusters for Hydrocarbon Production"
9:50 am - 9:55 am
Discussion
9:55 am - 10:10 am
"Investigation Into the Triiron Cofactor of an Iron-Dependent Oxidase Involved in Oxazolone and Thioamide Formation on a Copper-Binding Virulence Factor"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 11:00 am
"Mechanistic Investigation of Copper-Dependent Polysaccharide Monooxygenases"
11:00 am - 11:05 am
Discussion
11:05 am - 11:20 am
"The Role of Conformational Flexibility in Zinc and RNA Binding of ZRANB2, a CCCC-Type Zinc Finger Protein"
11:20 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Iron-Sulfur Cluster Architecture in Electron Bifurcation: Structure & Function"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Investigating Novel Chemistry of Plant Copper Peptide Cyclases"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Diverging Reaction Pathways and Key Intermediates in Ethylene Forming Enzyme"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:15 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
9:30 pm - 11:00 pm
Poster Session
Joint Poster Session with the Metals in Biology GRC
Monday
7:30 am - 8:30 am
Breakfast
9:00 am
Seminar Concludes