Friday
12:00 pm - 4:00 pm
Arrival and Check-in
2:30 pm - 4:00 pm
Poster Session
4:00 pm - 4:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
4:15 pm - 6:00 pm
Elements in Motion: Driving Progress in Health, Environment, and Energy
4:15 pm - 4:20 pm
Introduction by Discussion Leader
4:20 pm - 4:35 pm
"Bacterial Bioleaching and Biorecovery of Rare Earth Elements in Abandoned Coal Mine Drainage Applications in Biomining"
4:35 pm - 4:40 pm
Discussion
4:40 pm - 4:55 pm
"Lipid Environments of Particulate Methane Monooxygenase"
4:55 pm - 5:00 pm
Discussion
5:00 pm - 5:15 pm
"The Origin of Biological Nitrogen Fixation Predates the Iron-Molybdenum Cofactor (FeMoco) Maturases and Did Not Require Molybdenum"
5:15 pm - 5:20 pm
Discussion
5:20 pm - 5:35 pm
"Time-Resolved XFEL Structures of the Intermediates of the Ultra-Fast Light Reaction of Photosystem I"
5:35 pm - 5:40 pm
Discussion
5:40 pm - 5:55 pm
"Metal-Induced Redox Imbalance and p53 Misfolding in Lung Carcinogenesis"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unraveling the Mysteries of Metalloproteins: Utilizing Structural, Computational, and Omics Approaches
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"X-Ray Absorption Spectroscopy Measurements of the Mn4CaO5 Complex in Photosystem II at X-Ray Free-Electron Lasers"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Discovering New Enzymatic Strategies for Peptide Modification"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Exploring Sulfur Dynamics in Nitrogenase"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Computational Insights into the Role of Secondary Sphere Residues and Diiron Center Architecture in Controlling NO Reactivity in Hemerythin-Like Protein (HLP)"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Capturing B12-Dependent Methyl Transfer in the Wood-Ljungdahl Pathway via Cryo-EM"
9:25 pm - 9:30 pm
Discussion
Saturday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Engineering Nature’s Blueprint: Advancing Synthetic Bioinorganic Chemistry
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Engineering Nickel-Substituted Metalloenzymes as a Platform for the Electrochemical Synthesis of Value-Added Products"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Synthetic Motifs for Understanding Metal Thiolate and Selenolate Post-translational Modifications"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Bioinspired Photochemical CO2 Reduction in Water Using the Synthetic Mini-Enzyme CoMC6*a"
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Binding Modes Tuning Nitrite Reduction Reactivity at Iron(III) Centers Triggered by Hydrogen Atom, Hydride, and Proton Transfers"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Stabilizing Reactive Non-Heme Fe–NO Intermediates in a Rigid Macrocyclic Environment: Structural, Spectroscopic, and Reactivity Studies"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"A Reduced Mononuclear Nonheme Iron Nitrosyl Complex Leads to HNO Release"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Mechanistic Analysis of the [FeFe]-Hydrogenase Maturase HydE via EPR and Native Mass Spectrometry"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Tunable Organic Frameworks as a Platform for Stabilizing and selective Targeting of Enzymes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:15 pm - 6:00 pm
Metallic Harmony: Balancing Metal Homeostasis and Regulation in Biology
4:15 pm - 4:20 pm
Introduction by Discussion Leader
4:20 pm - 4:35 pm
"Copper(II) and Cobalt(III) Binding to Nsp1, a SARS-CoV-2 Protein"
4:35 pm - 4:40 pm
Discussion
4:40 pm - 4:55 pm
"H2S-Mediated Persulfidation of Zinc Finger Proteins is a Global Response to Pro-Inflammatory Stress"
4:55 pm - 5:00 pm
Discussion
5:00 pm - 5:15 pm
"Nitric Oxide Release and Exchange Upon UV Photolysis of a New C-Type Diazeniumdiolate Siderophore"
5:15 pm - 5:20 pm
Discussion
5:20 pm - 5:35 pm
"A New and Old tRNA Modification Reaction by the Radical SAM Enzyme YhcC"
5:35 pm - 5:40 pm
Discussion
5:40 pm - 5:55 pm
"Impact of H2S Mediated Persulfidation of the Classical Zinc Finger Protein Yin-Yang 1"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
7:30 pm - 9:30 pm
Reimagining Metalloenzymes: Evolutionary Strategy, Rare Metals, and Catalytic Innovation
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"How to Improve the Performance of Oxalate Decarboxylase"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"In Vitro Maturation of Fully Active [FeFe]-Hydrogenase in a Defined System Including the Iron Carrier NfuA"
8:20 pm - 8:25 pm
Discussion
8:25 pm - 8:45 pm
"Fused Lanmodulin Dimers for Enhanced Rate Earth Separations"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Metal Ion Effect on Electron Transfer in Rare Earth Artificial Metalloprotein"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Deciphering Metalloenzymes: Probing Mechanisms, Intermmediates, and Redox Chemistry
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Mechanistic Investigation of the Rieske Oxygenase, VanA, Involved in the O-Demethylation of Vanillic Acid"
9:25 am - 9:30 am
Discussion
9:30 am - 9:45 am
"Living on Thin Air: Investigating The Redox Landscape of Oxygen-Insensitive Huc [NiFe]-Hydrogenase Using Dipolar EPR Spectroscopy"
9:45 am - 9:50 am
Discussion
9:50 am - 10:05 am
"Thermodynamic Control of C-H Bond Activation by Cytochrome P450 High-Valent Intermediates"
10:05 am - 10:10 am
Discussion
10:10 am - 10:30 am
"Spectroscopic Studies to Understand the Early Intermediates of the V Nitrogenase Reaction Cycle"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Exploring Redox Network Engineering to Enhance the Catalytic Performance of Cytochrome P450"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Tracing Electron Transfer Pathways in the Bis-FeIV Forming Enzyme MbnH"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Insight into the Catalytic Mechanism of a 4-His Mononuclear Non-Heme Iron-Containing Carotenoid-Cleaving Oxygenase"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:15 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
9:30 pm - 11:00 pm
Poster Session
Joint Poster Session with the Metals in Biology GRC
Monday
7:30 am - 8:30 am
Breakfast
9:00 am
Seminar Concludes