Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Pneumonia in the Experienced Lung
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Pneumonia and Lung Resident Memory"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Respiratory T Cell Immunity"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Alveolar Macrophages and Lung Immunity: Do Prior Infections Matter?"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vulnerabilities Influencing Pneumonia Susceptibility
9:00 am - 9:30 am
"Role of Functional Programing of Alveolar Macrophages in the Susceptibility to Pneumonia After Acute Inflammation"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Understanding the Molecular Mechanisms of how Air Pollution Increases Susceptibility to Pulmonary Infections"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Airway Metabolites Shape Susceptibility to Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Investigating Neutrophil Migration and Regulation in Bacterial Models of Pneumonia"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Influenza A Virus Increases Susceptibility to Streptococcus pneumoniae by Reducing Host Defense in the Airway Surface Liquid"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Airway Prevotella Promote TLR2-Dependent Neutrophil Activation and Rapid Clearance of Streptococcus pneumoniae From the Lung"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Neonatal CD8+ T cells Demonstrate PD-1 Dependent Impairment Following Human Metapneumovirus Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Recent Advances in Innate Immunity
7:30 pm - 8:00 pm
"The Role of moDCs and Interstitial Macrophages in the Lung"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Mediating Host Disease Tolerance and Innate Immune Triage: The Lung as a Central Regulator"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Targeting Host Mediators in Influenza-induced Disease"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immunometabolism for Infection Control
9:00 am - 9:30 am
"Divergent Outcomes of Acute Lung Infection in the Obese Host"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Emerging Roles for Sterols in Pulmonary Defense and Resilience"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Roles for Specialized Pro-Resolving Mediators in Airway Inflammation Resolution"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"An Oxysterol Receptor Antagonist Reduces Macrophage Infiltration and Inflammation in the Lung During Influenza and SARS-CoV-2 Infection."
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Influenza A Virus Causes Shedding of the Alveolar Epithelial Glycocalyx through Activation of Sheddases"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Investigating the role of HIF1a in hMPV and RSV infections"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Single-Cell RNA-Sequencing Reveals Unique Metabolic Pathways for Long-Lived CD4+ Tissue-Resident Memory T Cell"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Networks in the Challenged Lung
7:30 pm - 8:00 pm
"Dynamic Programing of Airspace Macrophage Subsets Following Endotoxin Exposure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Manipulating Neutrophil Function in the Inflamed Lung"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Lung Endothelial Cell Regulation of Innate Immunity and Infection Control"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Long-term Sequelae of Respiratory Infections
9:00 am - 9:30 am
"Pneumococcal Pneumonia and its Association with Short- and Long-term Risk for Adverse Cardiac Events"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"T cells and Post-Viral Lung Sequelae"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Persistent Brain Dysfunction in Survivors of Pneumonia and Sepsis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Tissue Resident Foxp3+ Regulatory T Cells During Influenza Infections"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Circadian Regulation of Host Response to Streptococcus pneumoniae"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Local Ag Presentation to CD4 Effectors in the Lung and Signals from Continuing Infection Acting via Type I IFN and IL-15, Synergize to Drive Tissue-Resident Cytotoxic CD4 T Cell Differentiation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Nanoparticle Targeting of de novo Pro-fibrotic Macrophages Mitigates Lung Fibrosis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm
Non-traditional Aspects of Pulmonary Immunity
7:30 pm - 8:00 pm
"Regulation of Helminth Immunity in the Respiratory Tract"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Platelet-regulated Neutrophil Responses During Pulmonary Infection"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Understanding Pulmonary Immunity Using Human Organ Chips"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Advances in Pulmonary Defense
9:00 am - 9:30 am
"Function of APCs in Respiratory Viral Infection: More Than Meets the Eye"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Tuning T Cells for Lung Inflammation and Anti-inflammation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Heterogeneity Across Ciliated Cells Before and During Respiratory Viral Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Neutrophil Extracellular Traps (NETs) Increase Mucus Viscoelasticity and Promote Bacterial Aggregation"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Integrative Analysis of Spatial Transcriptome with Single-cell Transcriptome and Single-cell Epigenome in Mouse Lungs after Immunization"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Lung Epithelial Cell-derived C3 Protects Against Pneumonia-induced Lung Injury"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"BATF2 Mediates Pro-inflammatory Cytokine Production in Macrophages and Enhances Early Host Defense Against Pulmonary Klebsiella pneumoniae Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Resilience and Resolution of Inflammation
7:30 pm - 8:00 pm
"Epigenetic and Metabolic Dysfunction During Recovery from Influenza Infection"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Type 2 Immunity and Lung Injury"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Regeneration of the Alveolar Epithelium After Acute Respiratory Infection"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure