Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
New Insights into Host Defense and Pathogenesis
7:40 pm - 8:10 pm
"Initiation and Regulation of Innate Immunity"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Biomimetic Nanotherapeutics and Nanovaccines for Bacterial Pneumonia and Sepsis"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Circulating Bacteriophages and the Diagnosis of Bacterial Lung Infections"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Immune Cells in Pneumonia
9:00 am - 9:25 am
"Molecular Mechanisms of Innate Immunity and Inflammation in Health and Disease"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"The Inflammatory Lung Microenvironment at the Time of Exposure Governs Innate Resistance to SARS-CoV-2 in Mice"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Lung Interstitial Macrophage Responses During and After Recovery from Pneumococcal Respiratory Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"The Role of Ion Channels in Neutrophil Extracellular Trap Formation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Elucidating the Role of Streptococcus Pneumoniae Capsule in Innate Immune Responses in Macrophage"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Hidden Role of Eosinophils During Bordetella Spp. Infections"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Role of Tryptophan Metabolites and AHR Signaling in Coronavirus Exacerbations of Pulmonary Fibrosis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Macrophage Peroxisomes Guide Proper Alveolar Repair and Prevent Post Acute Sequelae of COVID-19"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Bacterial Virulence in the Lung
7:30 pm - 7:55 pm
"Everybody Relax: Coxiella Subversion of Human Macrophage Stress Signaling"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"Age-Related Effects of Interferons on Outcomes of Bordetella Pertussis Infection"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"Determinants of Haemophilus Influenzae Colonization and Host Inflammatory Exacerbation in COPD Related Infection"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Neutrophil Extracellular Traps Promote Pseudomonal Infection of Human Bronchial Epithelia"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell Signaling Networks in Pneumonia
9:00 am - 9:25 am
"Nasal-Restricted Viral Infection Remotely Exacerbates Asthma Through B-Cell Dependent Recruitment of Inflammatory Monocytes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Lung Inflammation and Disease Severity During RSV Infection"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"TLR9 in Host Defense Against Influenza Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Neuroimmune Control of Acute Lung Inflammation"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Multiple Oral Commensal Aspiration Induces Resistance to Lower Airway Pneumococcus Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"The Species-Specific Impact of Airway Prevotella on Lung Infection Resilience"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Single-Cell RNA Sequencing Analysis of Oncostatin M-Oncostatin M Receptor Signaling in the Lungs"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cell-Specific CD40 Expression During Development of Lung-Resident Heterotypic Immunity"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Viral Pathogenesis in Pneumonia
7:30 pm - 7:55 pm
"Virus-Triggered Barrier Dysfunction: Mechanism, Impact, and Intervention"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"The Missing Shield: How RSV Severity Stems from Inadequate IgA Defenses in the Respiratory Mucosa of Infants"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"SARS-CoV-2 Pathogenesis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Altering Cellular Architecture: The Role of Coronavirus Non-Structural Proteins 3 and 4 in Membrane Deformation and DMV Formation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Structural Cells, Lung Matrix and Other Mediators in Pneumonia Outcomes
9:00 am - 9:25 am
"Impact of Tnr6a and Local Translation in Airway Epithelial Differentiation and Innate Immunity Development"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"TRPV4 Protects the Lung from Injury After Bacterial Pneumonia"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Oxidation of Hemoproteins by Streptococcus Pneumoniae Collapses the Cell Cytoskeleton and Disrupts Mitochondrial Respiration Leading to Cytotoxicity of Human Lung Cells"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Regulation of the Alveolar Regenerative Niche by Treg Cells in Acute Respiratory Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"CC16 and Epithelial Driven Host Responses During Infection"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Airway Fibroblasts Fuel S. Aureus Infection"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Influenza A Virus Induced Endoplasmic Reticulum Stress Confers Susceptibility to Streptococcus Pneumoniae"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Deciphering the Role of Host Lipids in Legionella Pneumophila Intracellular Replication"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Unusual Infections and Co-Infections in the Pneumonia Outcomes
7:30 pm - 7:55 pm
"Regulation of Helminth Immunity in the Lung"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
"The Intricate Relationship Between SARS-CoV-2, DAD and the Development of Secondary Infections"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
"The Impact of Influenza-Induced Glycocalyx Shedding on Secondary MRSA Pneumonia"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Innate Immunity in Reservoir Infections with Pathogenic Hantaviruses"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Age, Sex and Other Factors in Pneumonia Outcomes
9:00 am - 9:25 am
"Inflammatory Injury and Anti-Inflammatory Therapeutics in Third Trimester Primate Lung Development"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"The Influence of Sex and Obesity on Pulmonary and Extrapulmonary Myeloid Responses"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
"Sex Shapes Lung Antiviral Immunity Upon Heterologous Viral Infection"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Age-Specific Differences in the Innate Immune Response During Infant Respiratory Viral Infection"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Lung Intrinsic Resistance to Bacterial Infection in Obese Mice"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Sex-and Pathogen-Specific Airway Neutrophil Signaling in Cystic Fibrosis Airways"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Leptin's Role in the Response to Influenza Infection"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Neurologic Signals and Circadian Rhythms in Pneumonia Control
7:30 pm - 7:40 pm
"Vasoactive Intestinal Peptide Regulates Immunoglobulin Release in Response to Streptococcus Pneumoniae Infection"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 8:10 pm
"Type III IFN Sustains Adaptive Immune Responses to Limit Pulmonary Damage After Viral Infection"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Circadian Rhythm and Pneumonia"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Vagal Nociceptor Neurons Regulate Immune Responses and Respiratory Pathogen Infection Outcome"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure