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Biology of Aging

Gordon Research Conference

Evolving Concepts of Organismal Aging

July 2 - 7, 2023

Chairs

and

Vice Chairs

and

Rey Don Jaime Grand Hotel

Avinguda de l'Hotel

Castelldefels, Barcelona, Spain

Venue and Travel Information

Conference Description

The Biology of Aging GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Aging research over the past decades has made great strides to identify key hallmarks of aging at an increasingly detailed molecular and cellular resolution. These advances have led to the growing recognition that aging is malleable and subject to interventions not just at the cellular level or in invertebrates but possibly in a range of vertebrates and even humans. With its overarching theme “Evolving concepts of organismal aging”, the 2023 "Biology of Aging" Gordon Research Conference will highlight diversity in aging research, incorporating cutting edge experimental approaches, discoveries, and will span model organisms to humans.

Related Meeting

This GRC will be held in conjunction with the "Biology of Aging" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Environment and Stem Cell Aging Discussion Leader:
7:40 pm - 8:20 pm	"Understanding Aging and Suspended Animation"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Tissue Resident Mesenchymal Stem Cells as Regulators of Skeletal Muscle Aging"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"Longitudinal dynamics of clonal haematopoiesis identifies gene-specific fitness effects"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Red vs. White: How Failure in Red Blood Cell Recycling Drive T Cell Aging."
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Microbiome and Diet During Aging Discussion Leader:
9:00 am - 9:30 am	"Mechanisms Underpinning Poor Vaccine Responses in Older Individuals"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Microbiota Polypharmacology for Improving Ageing"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"The Tempo and Mode of Evolution of E.coli in the Mammalian Intestine"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Aged Intestinal Stem Cells Acquire and Propagate Cell-Intrinsic Sources of Inflammaging"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Microbial Aging - A Role for Metabolite Exchange Interactions"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Cyclic Ketogenic Diet Increase Dendritic Complexity of Cortical Neurons through MAP2 Phosphorylation and BDNF Signaling Pathway Activation in Prefrontal Cortex of Aged Mice"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Immune Aging Discussion Leader:
6:00 pm - 6:30 pm	"Immunometabolism at the Crossroad Between Inflammation and Aging"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:10 pm	"Reconstructing Dynamics of Cellular Environments in Aging Brains"
7:10 pm - 7:20 pm	Discussion
7:20 pm - 7:50 pm	"The cGAS-STING Pathway Drives Aging-Associated Inflammation and Neurodegeneration"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Comparative Biology of Aging Discussion Leader:
9:00 am - 9:30 am	"The Genetics of Aging at Cellular, Organismal, and Population Scales"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Regulation of Cell Death and Cellular Senescence in the Long-Lived African Mole-Rats"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"The Proteome of the Aging Vertebrate Brain"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"DNA Repair and Anti-Cancer Mechanisms in the Longest-Living Mammal: The Bowhead Whale"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Parental Age Effects on Offspring: Mechanisms and Consequences"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Maternal Age Effects on Offspring: Outcomes and Mechanisms"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	New Technologies to Study Aging Discussion Leader:
6:00 pm - 6:30 pm	"The Impossibility of Whales: Somatic Mutation Across the Tree of Life"
6:30 pm - 6:40 pm	Discussion
6:40 pm - 7:15 pm	"What Drives Age-Related Methylation Dynamics?"
7:15 pm - 7:20 pm	Discussion
7:20 pm - 7:55 pm	"Turn your Mito ON! - Towards Energy Replacement in Aging"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cell Intrinsic Versus Extrinsic Aging Discussion Leader:
9:00 am - 9:30 am	"Molecular Regulation of Reproductive Aging in Human Females"
9:30 am - 9:40 am	Discussion
9:40 am - 10:10 am	"Regulation of Stem Cell fate and Aging by Mechanical Forces"
10:10 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:20 am	"Deciphering Human Antibody Repertoires against the Microbiome in Ageing"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"Macrophages: Key Players in the Aging Peripheral Nerve?"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"Counteracting Age-Related Microvascular Dysfunction extends Health and Lifespan of Mice."
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Age-Dependent Cytokine Surge in Blood Precedes Cancer Diagnosis"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Systems Biology of Aging Discussion Leader:
6:00 pm - 6:50 pm	"Peripheral Drivers of Alzheimer's Disease and Dementia Identified Using Plasma Proteomics"
6:50 pm - 7:00 pm	Discussion
7:00 pm - 7:50 pm	"A Circuit Approach to Dissect the Complexity of Aging"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Immune Interventions, Vaccines and Aging Discussion Leader:
9:00 am - 9:40 am	"Molecularizing the Whispers of Aging from Blood to Target Disease"
9:40 am - 10:00 am	Discussion
10:00 am - 10:25 am	"Resilience to Cognitive Decline to Escape Dementia: What we can Learn from Cognitively Healthy Centenarians"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Non-Human Primates as Models to Studying Systemic and Brain Aging"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Distinct Male and Female Hematopoietic Aging Phenotypes in Mice"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	"Ribosome Dynamics during Aging"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Keynote Session: Aging therapeutic strategies Discussion Leader:
6:00 pm - 6:15 pm	"Microautophagy is Essential to Repair Damaged Lysosomes and Prevent Aging"
6:15 pm - 6:20 pm	Discussion
6:20 pm - 7:00 pm	"Modulating Immune Cells and Inflammation to Rejuvenate the Aged Neurogenic Niche"
7:00 pm - 7:05 pm	Discussion
7:05 pm - 7:45 pm	"Harnessing Senolytic CAR T Cells to Reverse and Prevent Aging Phenotypes"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:00 pm	Closing Remarks
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Calico Life Science, Llc

N/A

Research reported in this publication was supported by the National Institute On Aging of the National Institutes of Health under Award Number R13AG082387. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Biology of Aging (GRS)

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