Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Understanding Mycobacterial Physiology Through Phages
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Intracellular Activity of Mycobacteriophages"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Mycobacteriophages: A Trick of the Tail"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution of Mycobacteria
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Pathoadaptation of M. tuberculosis Biofilms"
9:30 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Pathogen and Host Dynamics of Animal-Adapted Mycobacterium mungi "
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"The Ecology and Evolution of Multidrug-Resistant Mycobacterium tuberculosis "
11:25 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Metabolic Drivers of Genome Evolution in Mycobacterium tuberculosis "
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Paradigms in Metabolism
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Nature Can Teach an Old Dog New Tricks: How an Ordinary Enzyme of Central Carbon Metabolism Became a Key Regulator of Virulence and Metabolism"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Mycobacterial Shapeshifting: Inferring Metabolic Perturbation from Morphology"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Measuring the Mycobacterial Carbon Footprint: Reduce, Reuse, Recycle"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"MCE Proteins Form Large Complexes Mediating Lipid Transport Across the Cell Envelope"
9:30 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Mycobacterial Cell Envelope: Offense and Defense Against Host Cells"
10:05 am - 10:20 am
Discussion
10:20 am - 10:45 am
Coffee Break
10:45 am - 11:05 am
"Measuring Cell Envelope Membrane Variation Across Mycobacteria"
11:05 am - 11:20 am
Discussion
11:20 am - 11:40 am
"Decorating Cell Envelope Polysaccharides as a Means to Alter the Course of TB Infection"
11:40 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Regulation of Cell Envelope Biogenesis in the Model Organism Corynebacterium glutamicum"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Found in Translation: DNA Repair to Mistranslation as Survival Strategies
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Phase Variation Tunes Virulence and Antibiotic Efficacy in Mtb"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Tales of Non-Canonical Protein Synthesis: Mycobacteria as the Model Organism"
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Leaderless Translation Initiation: An Uncommon Process Common in Mycobacteria"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Exploring Protein-Protein Interactions within Mycobacterial ESX Substrates"
9:30 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Mobilizing the Type VII Secretion Army of Mycobacterium marinum "
10:05 am - 10:20 am
Discussion
10:20 am - 10:30 am
Short Talk Selected from Poster Abstracts
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Characterizing Substrates of the Type VII Secretion System"
11:25 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"A Secreted Mycobacterial Effector Modulating Host Macrophage Motility"
12:00 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Resistance and Persistence
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Killing Mtb via Partial Gene Inactivation"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:40 pm
"Role and Structure of Surface Glycolipids in the Smooth-to-Rough Transition and Pathogenesis of Mycobacterium abscessus "
8:40 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
"Cell Wall Metabolic Control Systems Impact Antibiotic Tolerance"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:35 am
"Role of ESX-5 Secretion in Mycobacterium tuberculosis Physiology and Pathogenesis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:05 am
"Carbon Source Specific Mechanisms Restrict M. tuberculosis Growth at Acidic pH"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
"Mycobacterial Stress During Chronic Infection"
11:10 am - 11:25 am
Discussion
11:25 am - 11:45 am
"Mycobacterial Responses to Life Inside Innate Immune Cells"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Random-Barcoded Transposon Sequencing (RB-TnSeq) Reveals Novel Determinants of Carbon Source Utilization in M. tuberculosis "
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Next Generation ‘Omics of Mycobacterial Physiology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Identifying the Enzymes Responsible for N-Terminal Acetylation of Mycobacterial Virulence Factors"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Towards Understanding the Regulation of mRNA Degradation in Mycobacteria: Identification of Novel Components and Their Interactions"
8:30 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"On Life Support: Exploring TB Persisters"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure