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Biology of Mycobacteria

Gordon Research Conference

Biochemistry, Genetics and Physiology of Mycobacteria and Related Genera

April 6 - 11, 2025

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GRC Education Requirements: Undergraduates or those who have not obtained a bachelor's degree in science/engineering (or acceptable equivalent) are not eligible to apply to attend Gordon Research Conferences or Seminars.

Chair

Vice Chair

Sheraton Fairplex Hotel & Conference Center

601 West McKinley Ave.

Pomona, California, United States

Venue and Travel Information

Application Information

The application deadline for this meeting was March 9, 2025. You may still submit an application, which may be considered by the conference chair if there is still room available.

Conference Description

The Biology of Mycobacteria GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

This conference will bring together scientists studying various aspects of mycobacterial physiology. Mycobacteria include pathogenic and non-pathogenic species that inhabit a variety of niches and have a significant impact on human and animal health. Additionally, phylogenetically related bacterial genera including Rhodococcus, Corynebacterium, and Streptomyces share numerous biochemical pathways with Mycobacterium, thus the characterization of novel pathways in any of these species could bolster our understanding of this highly environmentally and medically relevant order of bacteria. Our goal is to bring scientists from all areas of expertise, with a focus on biochemistry, molecular biology and genetics, but we will also appeal to researchers from the areas of chemistry and genomics.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Understanding Mycobacterial Physiology Through Phages Discussion Leader:
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:30 pm	"Intracellular Activity of Mycobacteriophages"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	"Mycobacteriophages: A Trick of the Tail"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Evolution of Mycobacteria Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Pathoadaptation of M. tuberculosis Biofilms"
9:30 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Pathogen and Host Dynamics of Animal-Adapted Mycobacterium mungi"
10:05 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Accidents of Evolution? Copper Sensitivity in Common Lab Strains"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"The Ecology and Evolution of Multidrug-Resistant Mycobacterium tuberculosis"
11:25 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"Metabolic Drivers of Genome Evolution in Mycobacterium tuberculosis"
12:00 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Use of Split ALFA Proximity Proteomics to Discover a New Component of Mycobacterial RNA Polymerase"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New Paradigms in Metabolism Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Nature Can Teach an Old Dog New Tricks: How an Ordinary Enzyme of Central Carbon Metabolism Became a Key Regulator of Virulence and Metabolism"
8:05 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	"Mycobacterial Shapeshifting: Inferring Metabolic Perturbation from Morphology"
8:40 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Measuring the Mycobacterial Carbon Footprint: Reduce, Reuse, Recycle"
9:15 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Membrane Dynamics Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"MCE Proteins Form Large Complexes Mediating Lipid Transport Across the Cell Envelope"
9:30 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Mycobacterial Cell Envelope: Offense and Defense Against Host Cells"
10:05 am - 10:20 am	Discussion
10:20 am - 10:45 am	Coffee Break
10:45 am - 11:05 am	"Measuring Cell Envelope Membrane Variation Across Mycobacteria"
11:05 am - 11:20 am	Discussion
11:20 am - 11:40 am	"Decorating Cell Envelope Polysaccharides as a Means to Alter the Course of TB Infection"
11:40 am - 11:55 am	Discussion
11:55 am - 12:15 pm	"Regulation of Cell Envelope Biogenesis in the Model Organism Corynebacterium glutamicum"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Found in Translation: DNA Repair to Mistranslation as Survival Strategies Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Phase Variation Tunes Virulence and Antibiotic Efficacy in Mtb"
8:05 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	"Tales of Non-Canonical Protein Synthesis: Mycobacteria as the Model Organism"
8:40 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Leaderless Translation Initiation: An Uncommon Process Common in Mycobacteria"
9:15 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Protein Secretion Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:30 am	"Exploring Protein-Protein Interactions within Mycobacterial ESX Substrates"
9:30 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Mobilizing the Type VII Secretion Army of Mycobacterium marinum"
10:05 am - 10:20 am	Discussion
10:20 am - 10:30 am	"PPE51 Modulates Membrane Integrity in Mycobacterium marinum"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Characterizing Substrates of the Type VII Secretion System"
11:25 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"A Secreted Mycobacterial Effector Modulating Host Macrophage Motility"
12:00 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Intrinsic Flexibility of the Type VII Secretion Central Pore Is Required for Substrate Translocation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Resistance and Persistence Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Killing Mtb via Partial Gene Inactivation"
8:05 pm - 8:20 pm	Discussion
8:20 pm - 8:40 pm	"Role and Structure of Surface Glycolipids in the Smooth-To-Rough Transition and Pathogenesis of Mycobacterium abscessus"
8:40 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	"Cell Wall Metabolic Control Systems Impact Antibiotic Tolerance"
9:15 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Stress Responses Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Role of ESX-5 Secretion in Mycobacterium tuberculosis Physiology and Pathogenesis"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Carbon Source Specific Mechanisms Restrict M. tuberculosis Growth at Acidic pH"
10:05 am - 10:20 am	Discussion
10:20 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Mycobacterial Stress During Chronic Infection"
11:10 am - 11:25 am	Discussion
11:25 am - 11:45 am	"Mycobacterial Responses to Life Inside Innate Immune Cells"
11:45 am - 11:55 am	Discussion
11:55 am - 12:15 pm	"Random-Barcoded Transposon Sequencing (RB-TnSeq) Reveals Novel Determinants of Carbon Source Utilization in M. tuberculosis"
12:15 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Next Generation ‘Omics of Mycobacterial Physiology Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Identifying the Enzymes Responsible for N-Terminal Acetylation of Mycobacterial Virulence Factors"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Towards Understanding the Regulation of mRNA Degradation in Mycobacteria: Identification of Novel Components and Their Interactions"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:15 pm	"On Life Support: Exploring TB Persisters"
9:15 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

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Poster Information

Poster sessions are an integral part of the our conferences, and offer all conferees an opportunity to discuss their research.

Preparing your GRC poster

Funding Opportunities

Financial assistance is available beginning in 2026 for qualified applicants through the Carl Storm Opportunity Fellowships program. Learn more.

Registration Fees

Conferee Single Room:

$1,730.00

Conferee Shared Room:

$1,470.00

Conferee Off-Site:

$1,280.00

Guest Single Room:

$1,540.00

Guest Shared Room:

$1,280.00

Guest Off-Site:

$1,090.00

Child 4-12 yrs Shared Room:

$640.00

Child 4-12 yrs Off-Site:

$545.00

Child Under 4 yrs Shared Room:

Free

Child Under 4 yrs Off-Site:

Free

Additional Fee Info

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