Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Ecology and Epidemiology of Pathogenic Spirochetes
7:40 pm - 8:00 pm
"Unravelling the Epidemiology of Treponema pallidum "
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
"Disentangling the Twisted Complexity of Borrelia burgdorferi Sensu Lato in Europe"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
"Signaling Systems of Treponema denticola That Regulate Central Metabolism and Polymicrobial Interactions"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Leptospirosis as an Outbreak-Prone Yet Neglected Disease within an Island Ecological System"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring The Post-Genomic World of Spirochetes
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Functional Genomics in T. pallidum "
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Breaking Barriers: Unraveling Leptospira Virulence Strategy by Host-Leptospira Transcriptomes"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Organization and Segregation of A Highly Segmented Bacterial Genome"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Culture-Independent Tools for Genomic and Genetic Characterization of Pathogenic Leptospira : DNA Capture and Enrichment and Amplicon Sequencing"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Borrelia Burgdorferi BosR Binds Small Non-Coding RNAs (sRNAs): Implications for Borrelial Post-Transcriptional Gene Regulation and Pathogenesis"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"Genomic Insights into T. Pallidum Through Ancient and Modern Genomes and Bbioinformatic Processing"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling and Gene Regulation in Spirochetes
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Transcriptomic Studies Reveal Unexpected B. burgdorferi Regulators"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"A Potential Role for vlsE Transcription in the Gene Conversion Mechanism in Borrelia burgdorferi "
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Adaptation of an In Vitro Generated Human Skin Model for Tick Feeding and Pathogen Transmission"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"CheA1 , A Chemosensory-Like Histidine Kinase Dispensable for Bacterial Chemotaxis but Regulates The Virulence of Borrelia burgdorferi "
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Host Responses in Spirochete Infections
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Immune Modulators of Leptospira Pathogenesis in Mice"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Peromyscus Deer Mice: A Novel Rodent Model of Acute Leptospirosis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:25 am
"In Search for Animal Models for Spirochetal Vector-Borne Diseases"
10:25 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Pursuing the Bacterial and Host Mechanisms Governing Borrelia burgdorferi -Related Type I Interferon Responses"
11:25 am - 11:35 am
Discussion
11:35 am - 11:50 am
"Development of A T-Cell-Directed Lyme Disease Vaccine"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Spirochetes in Their Vectors and Reservoirs
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Dissecting Peromyscus Leucopus Interactions with Ixodes Scapularis and B. Burgdorferi"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Leptospira Infection in Reservoir Hosts: Challenges in Surveillance and Detection"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Inverse Correlation Between Adhesivity and Crawling Motility in Leptospira Interrogans"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Borrelia Burgdorferi as A Beneficial Symbiont? An Arthropod-Centric View of Host-Microbe Interactions in A Vector-Borne Disease System"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spirochetes-Host Interactions
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Interactions of Leptospira and Host: Still Greek to Us"
9:25 am - 9:35 am
Discussion
9:35 am - 9:50 am
"Genetics or Environment: What Supports Survival of Growth Arrested Borrelia Burgdorferi?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Characterization and Genomic Analysis of the Lyme Disease Spirochete Bacteriophage Ï•BB-1"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"The Effect of Responses Against Environmental Stress on The Pathogenicity of Treponema denticola "
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Metabolic Regulation of The Carbonyl Stress Pathway in Lyme Disease and Relapsing Fever Borrelia Species"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Borrelia Burgdorferi-Host Interactions as Novel Antimicrobial Strategies"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Proteins and Endoflagella in Spirochetes
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Role and Structure-Function of Lol and Lpt Pathways in Borrelia Envelope Biogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"The Uniqueness of Spirochetes at the Molecular Level: Structural Insights into Lyme Borreliae Membrane-Associated Proteins"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Intravital Microscopy Reveals Host Specificity of Chemotaxis/Motility Phenotypes for A Borrelia burgdorferi cheY2 Mutant"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"The Biophysics of Leptospira Motility"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translating Discoveries into Medical Applications for Patients
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Mechanisms of Immunity to Borrelia burgdorferi Revealed Through Structures of OspC-Antibody Complexes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"(Google) Translating Knowledge on Tick-Host-Pathogen Interactions into Preventive and Diagnostic Interventions for Human Tick-Borne Diseases"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
"Metabolic Modeling to Identify New Narrow Spectrum Drug Targets in Borrelia burgdorferi "
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Genomic Diversity of Treponema Pallidum Among Early Syphilis Patients Enrolled in A Global Consortium for Syphilis Vaccine Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Time-Course Transcriptomics Reveals Impact of Treponema Pallidum on Microvascular Endothelial Cell Function and Phenotype"
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
"From The Field To The Bench, and Back -Translational Research on Leptospirosis to Improve Prevention and Diagnostic"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Technologies Leading To Insights in Spirochete Research
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Dissecting Nutritional and Metabolic Pathways in Treponema pallidum "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:20 pm
"Generating a Toolbox to Analyse the Antibody Response to T. pallidum "
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Recent Advances in Leptospira spp. Genetic Manipulation"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Persistent Symptoms after Antibiotic Therapy for Lyme Disease : What's Past is Prologue"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure