Sunday
7:40 pm - 9:30 pm
Keynote Session: Biomechanics and Mechanobiology
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:20 pm
"Model-Guided Treatment Planning in Pediatric Cardiology"
8:20 pm - 8:40 pm
Discussion
8:40 pm - 9:10 pm
"The Role of Cell-Cell Junctions in Endothelial Fluid Shear Stress Mechanotransduction"
9:10 pm - 9:30 pm
Discussion
Monday
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Mechanosensors and Signal Transduction
9:00 am - 9:15 am
"Flow-Induced Reprogramming of Endothelial Cells, Fire, in Atherosclerosis Development"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Vascular PIEZO Mechanoreceptors"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Lipid Regulation of Endothelial Stiffness in Obesity and Aging"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Mechanosensitive Notch1 Transducer in the Endothelium"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Disturbed Flow Downregulates LATS1/2, Driving Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Viscoelastic Property and Barrier Role of the Glycocalyx in Cells"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Distinct Regulation of Gene Expression by Laminar and Disturbed Flow in Human Vascular Endothelial Cells"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Accelerated Elastin and Collagen Remodeling in Sickle Cell Disease: Biomechanical and Biochemical Stimuli"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Kindlin-2 in the Mechanical Regulation of Vascular Development and Disease"
12:25 pm - 12:30 pm
Discussion
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hour™ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
7:30 pm - 9:30 pm
Cardiovascular Hemodynamics and Resilience
7:30 pm - 7:45 pm
"The Plaque Hypothesis: Fundamental Pathobiology of Coronary Atherosclerosis and Clinical Implications for Chronic Ischemic Heart Disease Management"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Endothelial Piezo1 Channel Mediates Mechano-feedback Control of Brain Blood Flow"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Vascular Smooth Muscle Cell Resilience and Aging"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"The Cardiac Microvasculature Responses in the Context of Ageing"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Reversal of Cerebrovascular Anomalies in a Zebrafish Model of Vein of Galen Aneurysm"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Deciphering Aortic Aging: Lessons from Mouse Models"
9:25 pm - 9:30 pm
Discussion
Tuesday
9:00 am - 12:30 pm
Biomechanics and Mechanobiology of Aneurysms and Disease
9:00 am - 9:15 am
"Mechanobiological Control of Vascular Adaptation and Disease Progression"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Digital Twins: Biophysical Targeted based Drug Delivery to Brain Aneurysms"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Deep Learning Generation of Intracranial Aneurysm Geometries to Specific Clinical Morphological Parameters for Fluid Dynamics Investigations"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Mechanotransducers for Endothelial Homeostasis"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Diagnosing Heart Failure from Arterial Pulse Wave Characteristics"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Mechanical Activation of Endothelial Reprograming by an Interleukin-1 Receptor Mechanism"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Pulmonary Hemodynamics and Mechanobiology: From Bench to Bedside"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Dual Roles of Mechanosensitive Platelets in Aneurysm Initiation and Progression"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"The Role Endothelial PGC1a in AAA"
12:25 pm - 12:30 pm
Discussion
4:00 pm - 6:00 pm
Poster Session
7:30 pm - 9:30 pm
Valvular Biomechanics and Mechanobiology
7:30 pm - 7:45 pm
"Cell Mechanics in the Process of Endocardial Remodeling and Cardiac Valve Morphogenesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Mechanics and Mechanobiology of Vascular Calcification"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Mechanical and Cellular Asymmetry in Aortic Valve Physiology and Disease"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Role of Angiotensin Signaling in Mediating Aortic Valve Mechanics and Disease"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Integration of Cellular Proteomics and Vesiculomics to Assess 3D Bioprinted Model of Calcific Aortic Valve Disease"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Mechanobiological Regulation of Fetal Outflow Tract Morphogenesis"
9:25 pm - 9:30 pm
Discussion
Wednesday
9:00 am - 12:30 pm
Developmental and Stem Cell Biomechanics Toward Precision Medicine
9:00 am - 9:15 am
"Matrix Mechanics Regulation of Vascular Formation and Homeostasis"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Dissecting Mechanosignaling in hiPSC Disease Models"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Reprogramming Mechanogenetics for Cell Therapy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Mechanoenzyme and Cell Mechanointelligence"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Discovery of Inflammation-Dependent Mechanisms of Cardiovascular Calcification"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Extracellular Matrix Mechanics on Endothelial Phenotype"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Precision Nanomedicine Targeting Novel Endothelial Mechano-Sensing Mechanisms to Treat Vascular Diseases"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Mechanotransduction in Cerebral Small Vessel Disease"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Dynamic Phenotypic Transitions of Smooth Muscle Cells in Aortic Disease Progression"
12:25 pm - 12:30 pm
Discussion
4:00 pm - 6:00 pm
Poster Session
7:30 pm - 9:30 pm
Plaque Biomechanics in Atherosclerosis
7:30 pm - 7:45 pm
"EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Imaging Carotid Plaque Structure to Help Predict Rupture"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Biomechanics and Sex-Related Differences in Atherosclerosis"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"ACE2, Shear Stress, and EC Biology"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Quantifying the Impact of Disturbed Flow and Arterial Stiffening on Mechanotransduction in Endothelial Cells"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"RBC-Membrane Adhesive Tangles (MATs): A Biomechanical Catalyst for Atherosclerotic Plaque Thrombosis"
9:25 pm - 9:30 pm
Discussion
Thursday
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cardiovascular Imaging and Computation
9:00 am - 9:15 am
"Photoacoustic, Light-Speed, and Quantum Imaging"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Assessment of Prothrombotic Hemodynamics in the Carotid Arteries in Subjects Who Have Had a Stroke or TIA"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Quantifying Ascending Aortic Aneurysm Risk Through Magnetic Resonance Imaging-Based Biomechanics: A Machine Learning Approach"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Microstructurally Informed Mechanical Models for Fibrin and Collagen Networks: Can We Predict Mechanical Behaviour and Failure"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Towards a ‘Digital Twin’ for Stroke Prevention: A Microengineered Carotid Artery Platform for Personalized Thrombotic Risk Assessment and Drug"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Modeling the Vascular Microenvironment: Implications in Cardiac Health"
11:25 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Characterization of Cardiac Morphogenesis and Contractile Function with Cellular Resolution"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"3D Imaging of Coronary Vascular Architecture in the Mouse Model of Repetitive Ischemia"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"On the Role of Calcification in the Pathology of Cerebral Aneurysms"
12:25 pm - 12:30 pm
Discussion
4:00 pm - 6:00 pm
Poster Session
7:30 pm - 9:30 pm
Cardiovascular Biomechanics and Mechanobiology
7:30 pm - 7:45 pm
"Thera-Mechanics: From Force to Therapy"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Latest Insights into Atherosclerosis and Shear Stress using Machine Learning"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Flow Modulation of Endothelial Ca2+ Signaling Dynamics"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Harnessing Ribonucleoprotein Complexes to Engineer Cell Mechanics"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Horizontal Mitochondrial Transfer from Endothelial Cells under Mechanochemical Stress"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Beyond Flow Patterns: Paving the Way Toward Mechanobiological Insights in Cardiovascular Disease"
9:25 pm - 9:30 pm
Discussion