Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Definition, Location, and Function of Stem and Progenitor Cells
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"Growth Plate Stem Cell Actions in Mosaicism"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"An Unexpected Role for Hoxa11-Expressing Musculoskeletal Stromal Cells in Muscle"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Heterogeneity and Functional Specialization of Endothelial Cells in Bone"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Complex Inflammasome-Mediated Inflammatory Responses in Bone Resorption"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Pathways Driving Inflammatory Osteoclastogenesis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Osteoclast Functional Heterogeneity During Aging"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Epigenetic Control of Skeletal Aging by KDM4B"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"High Levels of Efferocytosis by Mesenchymal Stromal Cells Increases their Senescence, Decreases Bone and Causes Myeloid Skewing"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mitochondrial Protein Deacetylation by SIRT3 Promotes Osteoclast Maturation and Bone Loss in Young Adult Mice Exposed to Low Dose Ionizing Radiation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Control of Bone and Tooth Development
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Mitochondria and the Control of Skeletal Development"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"What Big Feet You Have! Evolution of Skeletal Proportion in Bipedal Jerboas"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Development and Renewal of the Dentition Using the Mouse Incisor as a Model"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"An Adipo-Osteo Progenitor Contributes to Bone and Marrow Formation in Adult Mice"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Responding to Mechanical Signals
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"New Tools, New Questions: Recent Advancements in Intravital Studies of Osteocyte Mechanobiology"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Targeting Fracture Gap Oxygenation for Bone Regeneration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Biomechanical Signals and Heterotopic Ossification"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Wnt-Directed CXCL12-Expressing Apical Papilla Mesenchymal Progenitor Cells Drive Tooth Root Formation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Mechanosensitive Osteolectin+ Cells in Skeletal Development and Homeostasis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Role of DPP in Tissue Regeneration"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Hedgehog Signaling in Cranial Bone Regeneration"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Endochondral Repair of Jawbone Defects Using Periosteal Cell Spheroids via Enhanced p38 MAPK Pathway"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Osteopetrosis: Nosology, Significance and Therapy"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Recessive Variants in the C-terminal Domain of UFSP2 are Associated with Severe Spondyloepimetaphyseal Dysplasia"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Preventing Calcification and Improving Bone Health with ENPP1 Enzyme Replacement Therapy: From Bench to Bedside"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"The Contributions of Osteopontin Phosphorylation to Dentoalveolar Defects in X-linked Hypophosphatemia"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"The Collagen Receptor, Discoidin Domain Receptor 2 (DDR2) Regulates BMP-Induced Ossification and Fibrodysplasia Ossificans"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Hormonal Impacts on the Skeleton
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Intracellular Mediators of PTH Action in Target Tissues"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Glucocorticoids Impact on the Growing Skeleton"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
"Genomic Regulation of the GNAS Gene Expression to Fine-Tune PTH Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Blocking Activation of the Parathyroid Hormone Receptor Type 1 (PTH1R) with a Specific and Orally Available Antagonist is a Promising Therapy for the Treatment of Primary Hyperparathyroidism (PHPT)"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Tendon-Bone Communication"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Modelling Skeletal Ageing Phenotypes in Zebrafish"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Single Cell Cortical Bone Transcriptomics Define Novel Osteolineage Gene Sets Altered in Chronic Kidney Disease"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Bone Sialoprotein: From Bones to Teeth and Back Again"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Inclusive Living Subcellular Sequencing by iSCseq Rendering Physical, Physiological and Pathological Features in Osteoclast Diversity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Spatial Transcriptomics Reveals the Crosstalk Between ADGRG6 and SOX9 in Maintaining Chondrocyte Fate and Survival in Postnatal Growth Plates"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Osteoblasts as Cellular Targets in Bone Metastasis"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Bone Marrow Niches as Targets of Metastasis and Sources of Systemic Immune Suppression"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Targeting the HIF Signaling Pathway for the Radioprotection of Bone"
9:10 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure