Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Sensing the Environment from the Skeleton
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:10 pm
"The Weight of Weightlessness: Spaceflight and Skeletal Health"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"The Gut Microbiome, Aging and Bone Matrix"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Making Sense of Healing: Neuroregulation of Bone Repair"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Signaling Pathways in Osteoblasts
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Mechanism of G Protein Selectivity at the PTH Receptor: Implications for Its Druggability"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Role of Iron in Controlling Osteoblast Metabolism and Function"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Non-Canonical Wnt Signaling and Bone Anabolism"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"MMP14 Orchestrates the Bone-Marrow Microenvironment to Maintain Skeletal Stem Cells and Homeostasis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Brain and Bone Communications
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"CCN3, A Novel Hypothalamic Hormone for Sustaining the Maternal Skeleton and Progeny"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Skull Progenitors and Meningeal Lymphatics in Neuro-Craniofacial Disorders"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Control of the Nerve-Bone-Adipose Tissue Nexus"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Periosteal Progenitors in Bone
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Periosteal Skeletal Progenitors in Fracture Repair"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Periosteal Stem/Progenitor Cells in Bone Regeneration"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Dissecting the Physiology of Cambium-Layer and Fibrous-Layer Periosteum"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Mechanotransduction in the Periosteum: Single-Cell Transcriptomic Analysis"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cancer and Bone Interactions
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"New Roles for PTHrP in Breast Cancer"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Microenvironment and Bone Metastases"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Bone-Specific Mechanisms of Cancer Invasion and Metastasis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Craniofacial Bone and Tooth Development
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Stem Cells in Regulating Tooth Development and Tissue Homeostasis"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Making Extra Teeth: Replacement and Supernumerary Teeth"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Shaping the Tooth and Jaw Through Cellular Biomechanics"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Embryonic Origin of Mesenchymal Stem Cells in the Mouse Incisor"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Osteoclasts and Macrophages in Bones and Teeth
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Osteocyte Innate Immune Signaling in the Regulation of Bone Resorption and Hematopoietic Cell Dynamics"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Mapping RANKL and OPG-Expressing Cells in Bone and Their Role in the Rebound upon Denosumab Discontinuation"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Osteoclast Fusion in Health and Diseases"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Studying Rare Diseases of Mineralized Tissues
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"From Farm to Lab: Gene-Edited Sheep Transform Rare Bone Research"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Modeling Skeletal Dysplasia With Patient-Derived BM Osteoprogenitor Cells"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"New Sequencing Technologies for Diagnosis of Genetic Diseases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Aging Skeleton and Regeneration
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:00 pm
"Senescent Cell Populations in Aging Bone"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Designing Novel BMP-2 Mimetics: Advancing Craniofacial Bone Regeneration with Skeletal Stem Cells"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
"Targeting Stem Cell Depletion in Healthspan and Disease"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure