Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Signaling Pathways and Mechanisms Regulating the Development, Maintenance and Repair of the Skeleton
Our keynote session will set the stage for the seminar by introducing signaling pathways and mechanisms involved in the development, maintenance and repair of the skeleton. Dr. Lyons is a professor at UCLA and an accomplished senior scientist with numerous contributions to bone biology.
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:20 pm
"Cartilage and Bone Biology Matricellular Proteins BMP Signaling"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Mechanisms Regulating the Skeleton
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 7:55 pm
"Endoplasmic Reticulum (ER) Stress Transducer IRE1a Regulates Postnatal Bone Development and Bone Marrow Homeostasis"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Wnt Signaling Is Required for Phosphorylation of Erk1/2 During Murine Cranial Bone Development In Vivo "
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Wnts Produced by Osteo-Lineage Cells Inhibit Bone Resorption and Are Required for Loading-Induced Bone-Formation in Adult Mice"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Unique Populations of Skeletal Stem Cells Arise from the Growth Plate"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Glucose Catabolism via the Pentose Phosphate Pathway Controls Chondrocyte Function During Bone Development"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Notch Effector Hes1 Marks an Early Perichondrial Progenitor Cells in Endochondral Bone Development"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Molecular and Cellular Analyses of BMP-Dependent Coupling Signals Between Osteoclasts and Osteoblasts During Bone Remodeling"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Pathologies of the Skeleton and Their Therapies
9:00 am - 9:15 am
Introduction by Discussion Leader
9:15 am - 9:25 am
"The Aging Macrophage and Inflammatory Dysregulation Within Bone: Implications for Periodontal Disease"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Sex-Differences of Morphine Impact on Bone Homeostasis: Sustained Exposure Is Associated with Bone Loss and Altered miRNA Profiles in Male Mice"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Irisin Stimulates Osteoclast Differentiation and Function"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"A Novel Stem and Progenitor Cell Induced During Heterotopic Ossification"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Changes in 3D Genome Architecture During Chondrocyte Differentiation in the Pathogenesis of Human Skeletal Dysplasia"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Human Osteogenic Differentiation of iPSC-Derived Osteogenic Progenitors Studied by Transcriptome and Network Analyses"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Biglycan Regulates Inflammation and Bone Regeneration During Fracture Healing"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Career Paths in Science
1:30 pm - 2:30 pm
Panel Discussion
Navigating Career Paths in Science
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes