Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
The Multiple Facets of Calcium Signaling
Discussion Leader: Ivana Kuo (Loyola University Chicago, United States)
7:40 pm - 8:20 pm
Thomas Sudhof (Stanford University, United States)
"Calcium Signaling in Synapse Formation and Synaptic Plasticity"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Inna Slutsky (Tel Aviv University, Israel)
"Regulating the Interplay Between Stability and Plasticity by Calcium in Hippocampal Neurons"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Fan Yang (Zhejiang University, China)
"Molecular Mechanisms Underlying a Gain-of-Function Mutation in TRPV3 Ion Channel in Olmsted Syndrome"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Role of Calcium Signaling in Cancer and Redox Biology
Discussion Leaders: Christine Peinelt (University of Bern, Switzerland) and Andrew Thomas (Rutgers University, United States)
9:00 am - 9:20 am
Mohamed Trebak (University of Pittsburgh, United States)
"Rewiring the Ca2+ Signaling Toolkit in Colorectal Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Tatiana Rogasevskaia (Mount Royal University, Canada)
"Exploring the Role of NCKX5 in Pigmentation"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Volker Ellenrieder (University of Göttingen, Germany)
"Calcium and NFAT Signaling in Pancreatic Cancer Development and Therapy Resistance"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Maya Yassine (University of Lille , France)
"Calcium Channels and Prostate Cancer Drug Resistance"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rhian Touyz (McGill University, Canada)
"Calcium Signaling and Redox Biology in Health and Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Jose Antonio Enriquez (Centro Nacional de Investigaciones Cardiovasculares Carlos III, Spain)
"The Interplay Between H+ , Na+ and Ca2+ in Maintaining the Mitochondrial Electrochemical Gradient"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Wolfgang Graier (Medical University of Graz, Austria)
"Spatial Ca2+ Signaling Controls ß-Cell Metabolism and Integrity"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Jeremy Smyth (Uniformed Services University of the Health Sciences, United States) and Paola Pizzo (University of Padova, Italy)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Role of Calcium Signaling in Skin and Immune Cells
Discussion Leader: Patrick Hogan (La Jolla Institute for Immunology, United States)
6:00 pm - 6:20 pm
Stefan Feske (New York University School of Medicine, United States)
"SOCE and its Role in Th1 Mediated Immunity to Infection and Autoimmunity"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Anna Celli (University of California, San Francisco, United States)
"Calcium Signaling in Ageing Epidermis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Charlotte Odendall (King's College London, United Kingdom)
"Calcium-Calmodulin Signalling at the Host-Pathogen Interface"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Nuoqi Wang (Karolinska Institutet, Sweden)
"How Dantrolene Effect Endoplasmic Reticulum Ca2+ in Darier Disease"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Andreas Guse (University Medical Center Hamburg-Eppendorf, Germany)
"Novel Insights in NAADP Signaling"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Calcium Signaling in Subcellular Compartments
Discussion Leaders: Shmuel Muallem (National Institute of Dental and Craniofacial Research, NIH, United States) and Celia Regina Garcia (University of São Paulo, Brazil)
9:00 am - 9:20 am
Fabiana Perocchi (HMGU, Germany)
"Systematic Reconstruction of Mitochondrial Calcium Signaling Networks"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Amado Carreras-Sureda (University of Geneva, Switzerland)
"Spontaneous Mitochondrial Calcium Uptake and its Impact on ALS"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Thomas Langer (Max Planck Institute for Biology of Ageing, Germany)
"Proteolytic Control of Mitochondrial Calcium Homeostasis"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Marta Moskot (University of Gdansk, Poland)
"Lysosomal Metabolism Modulators Impact on Intracellular Ca2+ Level and Inflammation in Lymphocytes"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Rajini Rao (Johns Hopkins University, United States)
"Inter-Organellar Crosstalk by Secretory Pathway Ca2+-ATPases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Israel Sekler (Ben-Gurion University of the Negev, Israel)
"Physiological Implications of the Metabolic and Ca2+ Signaling Cross-Talk Between NCLX and the Cell Membrane"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Hong Zhang (Institute of Biophysics, Chinese Academy of Sciences, China)
"Decoding ER Ca2+ Transients to Assemble Autophagosome Initiation Sites"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Calcium Signals at Membrane Contact Sites
Discussion Leader: Nicolas Demaurex (Université de Genève, Switzerland)
6:00 pm - 6:20 pm
Tamas Balla (National Institute of Child Health and Human Development, NIH, United States)
"Mutual Dependence of Lipid Transfer and Calcium Signaling at ER-PM Contact Sites"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Petra Samardzija (Western University and Children's Health Research Institute, London, Ontario, Canada)
"Defining the SPCA2C Interactome Reveals Interaction with CCDC47 and Unique Links to Store-Operated Calcium Entry"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Marisa Brini (University of Padova, Italy)
"Parkinson’s Disease Related Proteins Impact on Mitochondrial Calcium Signaling by Modulating Organelle Contact Sites"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Cesar Cardenas (Universidad Mayor, Chile)
"Calcium (Ca2+) Fluxes at Mitochondria-ER Contact Sites (MERCS) are a new Target of Senolysis in Therapy-Induced Senescence (TIS)"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Paola Pizzo (University of Padova, Italy)
"Modulation of Membrane Contact Sites by Calcium Signals"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Calcium Channels and Transporters
Discussion Leaders: Annette Dolphin (University College London (UCL), United Kingdom) and Jonathan Soboloff (Temple University, United States)
9:00 am - 9:20 am
Grace Stutzmann (Chicago Medical School, Rosalind Franklin University of Medicine and Science, United States)
"Shared Ca2+ Handling Deficits in Neurodevelopmental and Neurodegenerative Diseases: A Cognitive Common Denominator?"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Oleta Sandiford (Rutgers University, United States)
"Understanding the Effects of High-Fat Diet on Ca2+-Regulation of Metabolism in the Liver"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
David Yule (University of Rochester, United States)
"Regulation of IP3R by Ca2+ and ATP"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Robert Tarran (Kansas University Medical Center, United States)
"ELD607 Inhibits Orai1 and Ameliorates Lung Disease in Cystic Fibrosis (CF) Ferrets"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Isabella Derler (Johannes Kepler Universität Linz, Austria)
"Novel Insights in Orai1 Channel Dynamics"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Murali Prakriya (Northwestern University, United States)
"Regulation of Astrocyte Reactivity and Brain Inflammation by Orai1 Calcium Channels"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Indu Ambudkar (National Institute of Dental and Craniofacial Research, NIH, United States)
"Structural Determinants of STIM2 N-Terminus that Control its Function"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Calcium Research: Novel Technologies and Translational Aspects
Discussion Leader: Yasuo Mori (Kyoto University, Japan)
6:00 pm - 6:20 pm
Robert E. Campbell (The University of Tokyo, Japan)
"Expanding the Color Selection and Capabilities of Genetically Encoded Calcium Ion Biosensors"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Mayesha Sahir Mim (University of Notre Dame, United States)
"Shining Light on Calcium-Mediated Morphogenesis: Forward Engineering Organ Development with Optogenetics"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
Alexander Flugel (University Medical Center Gottingen, Germany)
"Calcium Signaling as Trigger for CNS Autoimmunity"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Fitzwilliam Seibertz (Nanion Technologies, Germany)
"Atrial Fibrillation Associated Electrical Remodeling in Human Induced Pluripotent Stem Cell Derived Atrial Cardiomyocytes"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Marc Freichel (Universität Heidelberg, Germany)
"OCaR1 Endows Exocytic Vesicles with Autoregulatory Competence by Preventing Uncontrolled Ca2+ Release, Exocytosis, and Pancreatic Tissue Damage"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Calcium Signaling in Physiology and Pathology
Discussion Leaders: Aldebaran Hofer (Harvard Medical School and VA Boston Healthcare System, United States) and James Putney (National Institute of Environmental Health Sciences, United States)
9:00 am - 9:20 am
Gaiti Hasan (National Centre for Biological Sciences, India)
"The IP3 R and Mitochondrial Function in Flight Promoting Dopaminergic Neurons of Drosophila"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
Cecelia Mangione (Uniformed Services University, United States)
"The Heart in Spinal Muscular Atrophy: Dysregulated Calcium Homeostasis and Loss of β-Adrenergic Response"
9:40 am - 9:45 am
Discussion
9:45 am - 10:05 am
Jen Liou (University of Texas Southwestern Medical Center, United States)
"Regulation of PI Cycle at ER-PM Junctions During Receptor-Induced Calcium Signaling"
10:05 am - 10:15 am
Discussion
10:15 am - 10:25 am
Maria Claudia Caiazza (University of Oxford, United Kingdom)
"Molecular Basis of Calcium Homeostasis and Dyshomeostasis in Parkinson's Disease Patient-Derived Dopaminergic Neurons"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Geert Bultynck (KU Leuven, Belgium)
"BCL-2 Proteins in Ca2+ Signaling: Impact of Disease-Related Mutations and Accessory Proteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Anant Parekh (NIH, United States)
"CRAC Channels in the Innate Immune System"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Martha Cyert (Stanford University, United States)
"Discovering New Calcineurin Signaling Pathways"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Mitochondrial Calcium Signaling
Discussion Leader: Alexei Tepikin (The University of Liverpool, United Kingdom)
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
Gyorgy Hajnoczky (Thomas Jefferson University, United States)
"ER-Mitochondrial Calcium Coupling"
6:45 pm - 6:55 pm
Discussion
6:55 pm - 7:05 pm
Virdjinija Vuchkovska (Loyola University Chicago, United States)
"ER-Localized PC2 Mediates the UPR and Mitochondrial Calcium Under ER Stress"
7:05 pm - 7:10 pm
Discussion
7:10 pm - 7:50 pm
Rosario Rizzuto (University of Padova, Italy)
"Mitochondrial Calcium Signaling in Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure