Dinner 5:30-7:30pm

Keynote Session, 7:30-10:30pm

Tyler Jacks, Massachusetts Institute of Technology/HHMI, Chair

Arnold Levine, The Rockefeller University

Nikola Pavletich, Memorial Sloan-Kettering Cancer Center

Robert Weinberg, The Whitehead Institute, MIT

Monday Morning Session, 9:00am-12:45pm
RB pathway functions

Jackie Lees, Massachusetts Institute of Technology (Chair)
"Role of E2F in the control of cellular proliferation"

Kristian Helin, European Institute of Oncology
"Identification and characterization of E2F target genes"

Steven Hsu, National University Hospital, Singapore (short talk)
"TRIP-Br: a novel family of PHD zinc finger and bromodomain interacting proteins that regulate the transcriptional activity of E2F1-DP1"

Brenda Gallie, Hospital for Sick Children, Toronto
"Tumor suppression by pRB"

Wen-Hua Lee, University of Texas, San Antonio
"The retinoblastoma protein and chromosome segregation"

Monday Poster Session I, 4:00-6:00pm

Monday Evening Session, 7:30pm-10:30pm
Regulation of p53 I

Daniel Haber, MGH Cancer Center (Chair)

Moshe Oren, The Weizmann Institute of Science
"Regulation of p53 levels and activity: clues and questions"

Geoff Wahl, Salk Institute
"p19ARF in the p53-dependent G1 arrest mediated by DNA damage, microtubule disruption and ribonucleotide depletion"

Chikashi Ishioka, Tohoku University, Japan (short talk)
"Comparison of p53 and p51/p63 transcriptional properties in yeast and mammalian cells"

Charles Sherr, St. Jude's Children's Hospital/HHMI
"The ARF-p53 pathway"

Yue Xiong, UNC, Chapel Hill
"The ARF-MDM2-p53 pathway"

Tuesday Morning Session, 9:00am-12:45pm
Regulation of p53 II

Carol Prives, Columbia Medical School (Chair)
"Regulation of p53 and p53 family members"

Michael Kastan, St. Jude's Children's Hospital
"Common and distinct pathways involving ATM and p53"

Yosef Shaul, The Weizmann Institute of Science, Israel (short talk)
"Activation of p73 by the c-abl kinase"

Hyunsook Lee, University of Cambridge, England (short talk)
"Checkpoint inactivation fosters transformation of BRCA2-deficient cells"

Greg Hannon, Cold Spring Harbor Laboratories
"New methods to dissect p53 function"

Thanos Halazonites, The Wistar Institute
"Molecular mechanisms for ATM-dependent activation of p53"

Tuesday Evening Session, 4:00-6:30pm
In vivo models I

Terry VanDyke, UNC, Chapel Hill
"Elucidation of cancer mechanisms in the mutant mouse" (Chair)

Rene Bernards, Netherlands Cancer Institute
"E2F transgenic mice"

Hein te Riele, Netherlands Cancer Institute
"Role of the retinoblastoma gene family in murine development and tumorigenesis"

Ron DePinho, Dana-Farber Cancer Institute
"p53 and the response to telomere shortening"

Conference party, 8:00pm

Wednesday Morning Session, 9:00am-12:45pm
Rb and p53 action in cell cycle and cell death

Karen Vousden, NCI, Frederick (Chair)
"E2F1 potentiates cell death by blocking anti-apoptotic signals"

Scott Lowe, Cold Spring Harbor Laboratories
"p53 action in apoptosis and senescence"

Laura Attardi, MIT (short talk)
"A novel p53 target gene implicated in apoptosis"

Michael Korn, UCSF Cancer center
"The E2F, p14, p53 pathway in adenovirus infected cells"

Wafik El-Diery, Upenn/HHM
"Update on p53/TRAIL receptors and BRCA1/gene expression"

Poster Session II, 4:00-6:00pm

Wednesday Evening Session, 7:30-10:30pm
In vivo models II

Louise Strong, MD Anderson Cancer Center (Chair)
"p53 germline mutation and cancer risk in Li-Fraumeni syndrome: implications for models of tumorigenesis"

Gigi Lozano, MD Anderson Cancer Center
"Mouse models to study p53 function"

Christopher Crum, Brigham and Women's Hospital (short talk)
"p63 expression in early cervical neoplasia"

Larry Donehower, Baylor College of Medicine
"Does p53 regulate organismal aging?"

Frank McKeon, Harvard Medical School
"p53 homologues p63 and p73 in development and tumorigenesis"

Thursday Morning Session, 9:00am-12:45pm
Development, Differentiation and Neoplasia

Joe Nevins, Duke University/HHMI (Chair)
"Synergy in G1 regulatory pathways"

William Kaelin, Dana-Farber Cancer Institute/HHMI
"Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle"

Amy Yee, Tufts University School of Medicine (short talk)
"The HMG box transcriptional repressor HBP1 maintains a proliferation barrier in differentiated liver during regeneration"

Igor Matushansky, Albert Einstein College of Medicine (short talk)
"Control of terminal differentiation and cell division by cyclin-dependent kinases and their inhibitors"

Nick Dyson, MGH Cancer Center
"The Rb pathway in Drosophila"

Thea Tlsty, UCSF Cancer Center
"Early events in neoplasia"

Thursday Evening Session, 4:00-6:30pm
Regulation of the G1-S transition

David Livingston, Dana-Farber Cancer Institute (Chair)
"p300/CBP as transformation/tumor suppressor elements"

Emma Lees, DNAX, Palo Alto
"Substrates of cyclin-dependent kinases"

Doug Dean, Washington University in St. Louis
"Differential regulation of Rb functions by G1 CDKs"

Ed Harlow, MGH/HMS
"Spacial regulation of DNA synthesis in mammalian cells"

Conference banquet, 7:00pm