Sunday Evening
Keynote Session, 7:30-10:00pm | |
|
| 5:30-7:30pm | Dinner |
| Daniel Haber, Massachusetts General Hospital (Chair) |
| Harold Varmus, Memorial Sloan-Kettering Cancer Center
"Using Mouse Models in Cancer Research" |
| Bruce Ponder, Univ. Cambridge, UK
"Breast Cancer Predisposition after BRCA1 and BRCA2" |
| Albert de la Chapelle, Ohio State University
"Molecular genetics of colon cancer in the clinical context" |
| 10:00pm - ?? | Welcoming reception |
Monday Morning Session
9:00am-12:40pm | Genomic instability Syndromes and BRCA1/2 |
|
| 8:30am | Monday Morning Photo Shoot, (leave cafeteria by 8:20am!) |
| David Livingston, Chair |
| 9:00-9:40am | David Livingston, Dana Farber Cancer Institute
"Functional analysis of BRCA1 and 2" |
| 9:40-10:20am | Chu-Xia Deng, National Institutes of Health
"Brca1 and tumorigenesis" |
| 10:20-11:00am | Ashok Venkitaraman, Univ. Cambridge, UK
"Chromosomal instability and cancer predisposition: Insights from studies on BRCA2" |
| 11:00-11:20am | BREAK |
| 11:20-12:00pm | James Haber, Brandeis University
"Faithful and unfaithful repair of broken chromosomes: studying cancer in yeast cells" |
| 12:00-12:20pm | Haijuan Yang, Memorial Sloan-Kettering Cancer Institute (short talk)
"Crystal structure of PTEN Tumor Suppressor" |
| 12:20- 12:40pm | Nissim Hay, University of Illinois at Chicago (short talk)
"Activation of protein kinase B/AKT contributes to oncogenesis through abrogation of G2/M cell cycle checkpoint" |
| 4:00-6:00pm | Monday Poster Session I |
Monday Evening Session
7:30-10:30pm | Chromosomal Translocations: From Signaling Pathways to Therapeutics |
|
| Guillermina Lozano, Chair |
| 7:30-8:10pm | Pier Pandolfi, Memorial Sloan-Kettering Cancer Institute
"The Molecular Genetics of Acute Promyelocytic Leukemia and its therapeutic implications" |
| 8:10-8:50pm | Chris Denny, UCLA
"Oncogenic mechanisms of EWS/ETS fusion proteins" |
| 8:50-9:10pm | Jenise Wong, Harvard Medical School (short talk)
"Induction of the interleukin-2 receptor b-chain by the EWS-WT1 translocation product" |
| 9:10-9:50pm | Fred Barr, University of Pennsylvania
"Molecular consequences of chromosomal translocations in rhabdomyosarcoma" |
| 9:50-10:30pm | Brian Druker, Oregon Health Sciences University
"ST1571, A tyrosine Kinase Inhibitor for the Treatment of CML: Validating the Promise of Molecularly Targeted Therapy" |
| 10:30pm | Reception |
Tuesday Morning Session
9:00am-12:45pm | Developmental Pathways Linked to Cancer I (Wnt and Hedgehog) |
|
| Eric Fearon, Chair |
| 9:00-9:35am | Hans Clevers, Univ. Utrecht, Netherlands
"TCFs, mediators of Wnt signaling" |
| 9:35-10:10am | Paul Polakis, Genentech
"Interaction of APC and Axin in the wnt-1 pathway" |
| 10:10-10:45am | Eric Fearon, University of Michigan
"Contributions of APC/Catenin Defects to Colon Cancer" |
| 10:45-11:00am | BREAK |
| 11:00-11:35pm | Allen Bale, Yale University
"Hedgehog Pathway in Hereditary Human Disorders" |
| 11:35-12:10pm | Richard Pearse, Harvard Medical School
"Vertebrate Hedgehog Signal Transduction" |
| 12:10-12:45pm | Frederic de Sauvage, Genentech
"Hedgehog Signaling and Basal Cell Carcinoma" |
| 4:00-6:00pm | Tuesday Poster Session II |
Tuesday Evening Session
7:30-10:30pm | Developmental Pathways Linked to Cancer II (PTEN and SMADs) |
|
| Ramon Parsons, Chair |
| 7:30-8:10pm | Ramon Parsons, Columbia University
"Influence of IGF growth factors on PTEN +/-mouse tumorigenesis" |
| 8:10-8:50pm | Lewis Cantley, Harvard
"Role of PI 3-Kinase in Cell Growth and Survival" |
| 8:50-9:30pm | Joan Massague, Memorial Sloan-Kettering Cancer Institute
"TGF-beta signaling and cancer" |
| 9:30-10:10pm | Leigh Zawel, Johns Hopkins
"Signaling growth and death in colorectal tumors" |
| 10:10-10:30pm | Gloria Su, Johns Hopkins
"DPC4 pathway in pancreatic cancer" |
Wednesday Morning Session
9:00am-12:20pm | Genetic Models of Proliferation in Drosophila and C. elegans |
|
| Iswar Hariharan, Chair |
| 9:00-9:40am | Iswar Hariharan, Massachusetts General Hospital
"Genes that restrict cell growth and proliferation in vivo" |
| 9:40-10:20am | Tian Xu, Yale University
"The Lats Signaling Pathway in Regulation of Organ Size and Tumorigenesis" |
| 10:20-10:40am | Zeev Lev, Israel Institute of Technology (short talk)
"Brat: a potential brain tumor gene identified in Drosophila" |
| 10:40-11:00am | BREAK |
| 11:00-11:40pm | Gary Ruvkun, Harvard Medical School
"Genetic Analysis of C. elegans RTK/P13K/PTEN/PDK1/AKT Signaling to the key transcriptional output DAF-16FKHR/FKRHL1/AFX" |
| 11:40-12:20pm | Sander van den Heuvel, Massachusetts General Hospital
"Developmental control of cell division - using C. elegans as a model" |
| 3:00-5:00pm | Sailing Trip, Newport Harbor |
Wednesday Evening Session
7:30pm-10:30pm | Mouse Models: Tumor Progression and Modifier Loci |
|
| Terry Van Dyke, Chair |
| 7:30-8:10am | Terry Van Dyke, Univ. North Carolina
"Tumor suppression in vivo" |
| 8:10-8:50pm | Allan Balmain, UCSF
"Mouse Models for the Identification of tumor modifier genes" |
| 8:50-9:30pm | Doug Hanahan, UCSF
"Charting pathways of tumorigenesis" |
| 9:30-10:10pm | Gerhard Christofori, IMP, Vienna
"Modulation Tumor Cell Invasion and Metastasis in Transgenic Mice" |
| 10:10-10:30pm | Rong Wang, UCSF (short talk)
"Induction and Maintenance of Hepatocellular Carcinomas in Transgenic Mice" |
Thursday Morning Session
9:00am-12:20pm | Expression Profile Analysis in Cancer |
|
| Todd Golub, Chair |
| 9:00-9:40am | Todd Golub, Whitehead Genome Center
"Transcriptional Profiling in Cancer" |
| 9:40-10:20am | Jonathan Pollack, Stanford University
"Microarray analysis of gene expression and copy number in cancer" |
| 10:20-10:40am | Xin Chen, Stanford University (short talk)
"Genome-wide study of hepatocellular carcinoma with cDNA microarray" |
| 10:40-11:00am | BREAK |
| 11:00-11:40am | Oli Kallioniemi, National Institutes of Health
"Tissue microarrays for high-throughput molecular profiling" |
| 11:40-12:20pm | David Mack, Eos/Affymetrix
"Maximizing the use of Genome-Wide Knowledge and Functional Genomics Technologies for Clinical Utility in Cancer" |
| 6:00 pm | Conference banquet |
Thursday Evening Session
| High Throughput Gene Discovery |
|
| David Housman, Chair |
| 7:30-8:10pm | Michael Wigler, Cold Spring Harbor Laboratory
"Gene copy number measurements using microarray hybridization" |
| 8:10-8:50pm | Joe Gray, UCSF
"An array CGH view of ovarian cancer progression" |
| 8:50-9:30pm | Aravinda Chakravarti, Case Western Reserve University
"Microarray and Sequence based characterization of human genomic variation" |
| 9:30-10:10pm | Nick Dracopoli, Bristol Myers-Squibb
"Prediction of taxol response in breast and ovarian cancers" |
| 10:10-10:30pm | David Housman, Massachusetts Institute of Technology
Concluding Remarks |
| 10:30pm - ?? | Farewell reception |
