| Sunday July 29, 2001 |
| 7:30-7:45 | Welcome - Gigi Lozano, Chair |
| Session I: | Keynote speakers |
| Charles Sherr, St Jude Children's Research Hospital
"ARF Tumor Surveillance" |
| Doug Hanahan, University of California at San Francisco
"Multistage tumorigenesis: models, mechanisms and experimental therapeutics" |
| Monday July 30, 2001 |
| Session II: | Tumor suppressors |
| Luis Parada, U. T. Southwestern Medical Center |
| Zohar Sachs, Tufts Medical School
"Both Ink4a/Arf locus products synergize to induce crisis in Abelson transformation" |
| Bill Hahn, Whitehead Institute
"Cooperative interactions in the transformation of human cells" |
| Joanna Groden, University of Cincinnati
" New Twists for the BLM Helicase in Intestinal Tumorigenesis" |
| Raju Kucherlapati, Albert Einstein College of Medicine
""Mouse models for human HNPCC |
| Session III: | p53 |
| Carol Prives, Columbia University
"Keeping p53 in check" |
| Tyler Jacks, MIT
"Modeling Cancer in the Mouse" |
| Larry Donehower, Baylor College of Medicine
"Tumorigenesis and aging phenotypes in p53 mutant mice" |
| Louise Strong, U.T.M.D. Anderson Cancer Center
"Li Fraumeni syndrome: cancer risk and risk modifiers" |
| Yang Xu, University of California, San Diego
"Involvement of the phosphorylation of murine p53 at Ser 18 in the p53 responses to DNA damage" |
| Tuesday, July 31, 2001 |
| Session IV: | Cancer Genetics I |
| Ashok Venkitaraman, University of Cambridge
"Chromosome stability and the BRCA2 tumour suppressor" |
| Chuxia Deng, National Institutes of Health
"Brca1 and tumorigenesis" |
| Hakem Razqallah, Ontario Cancer Institute / AMgen Institute
"Mouse models for BRCA1 mutation" |
| Barbara Weber, University of Pennsylvania |
| Ulrica Westermark, Memorial Sloan Kettering Cancer Center
"BRCA1 and BARD1: a role in homology-directed DNA repair" |
| Hexin Chen, Johns Hopkins University
"Identification of HOXA5 targets in breast cancer cells" |
| Session V: | Cancer genetics II |
| Joseph Nadeau, Case Western Reserve University
"Genetic control of susceptibility to testicular cancer" |
| Peter Demant, The Netherlands Cancer Institute
"Genetic dissection of susceptibility to colon and lung cancer" |
| Monica Justice, Baylor College of Medicine
"Functional Genomics in the Mouse: Mutagenesis Strategies to Model Human Disease" |
| Amanda Toland, University of California at San Francisco
"Identification of human cancer modifier genes using mouse models" |
| Wednesday, August 1, 2001 |
| Session VI: | Oncogenes in transformation |
| Terry Van Dyke, University of North Carolina
"Inactivation of the Rb pathway in vivo: predisposition to multiple cancers by a common mechanism" |
| Eric Holland, Memorial Sloan Kettering
"Cell of origin, signal transduction, and cell cycle arrest, in gliomagenesis" |
| John Parant, University of Texas MD Anderson Cancer Center
"Rescue of embryonic lethality in mdmx null mice by loss of p53 suggests a non-overlapping pathway with MDM2 to regulate p53" |
| Jackie Lees, MIT
"The role of E2F in proliferation and tumorigenesis" |
| David Johnson, U.T.M.D. Anderson Cancer Center
"Dual Role of E2F1 in Cell Growth Control and Cancer" |
| Phil Hinds, Harvard Medical School
"Function of the retinoblastoma protein in osteogenic differentiation and cell cycle exit" |
| Session VII: | Genomics: |
| Anne-Lise Borrensen-Dale, the Norwegian Radium Hospital
"Gene expression patterns of human breast carcinomas distinguish tumor subclasses with potential clinical implication" |
| Ralf Krahe, Ohio State University
"Molecular profiling of multi-step carcinogenesis in squamous cell carcinomas of the head and neck" |
| Tim Hughes, Rosetta Inpharmatics
"DNA microarray expression profiling in yeast: implications for cancer research and therapy" |
| David Sabatini, The Whitehead Institute
"High-throughput approaches to analysis of gene function in mammalian cells" |
| Thursday, August 2, 2001 |
| Session VIII: | Cancer progression |
| Lynda Chin, Dana Farber Cancer Institute
"Functional Analysis of RAS, RB and p53 pathways in Melanoma Genesis and Maintenance" |
| Glenn Merlino, National Cancer Institute
"Modeling melanoma in the mouse" |
| Howard Crawford, Vanderbilt University
"Matrix Metalloproteinases in inflammation and tumorigenesis" |
| Zena Werb, University of California at San Francisco
"How proteases influence neoplastic progression" |
| Stephen Skapek, St. Jude Children's Research Hospital
"Persistent expression of cyclin D1 disrupts normal photoreceptor differentiation and retina development" |
| Session IX: | Genome integrity |
| Vicki Lunblad, Baylor College of Medicine
"Recruitment of multiple complexes to the telomere" |
| Ron DePinho, Dana Farber Cancer Institute
"Telomeres, tumor suppressors and tumorigenesis" |
| Pier Paolo Pandolfi, Memorial Sloan Kettering
"The role of PML in tumor suppression" |
