Sunday Evening
February 20th | Cancer Susceptibility Genes |
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| 7:30-7:50 | Welcome & Introduction, Bill Bennett, City of Hope & Beckman Research Inst, Los Angeles |
| 7:50-8:25 | William G. Kaelin, Dana-Farber Cancer Institute, Boston
The Von-Hippel Lindau tumor suppressor gene paradigm |
| 8:25-9:00 | Richard Gatti, UCLA, Los Angeles
Cancer susceptibility in ATM heterozygotes: Do two distinct carrier populations exist? |
| 9:00-9:10 | Break |
| 9:10-9:45 | Edward Giovannucci, Harvard School of Public Health, Boston
Folate, Methylene tetrahydrofolate reductase and colorectal cancer |
Monday Morning
February 21st | Chemoprevention |
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| 8:50-9:05 | Resident Manager's Welcome & Chair's Announcements |
| 9:05-9:20 | Introduction by Discussion Leader, Bruce Ames, UC Berkeley |
| 9:20-10:00 | Bruce Ames, UC Berkeley
Prevention of cancer and delay of aging with micronutrients |
| 10:00-10:45 | Laverne Mooney, Columbia University, New York
Antioxidant vitamin interventions in high-risk populations |
| 10:45-11:10 | Coffee Break & Group Photography |
| 11:10-11:50 | Ernie Hawk, NCI, NIH, Bethesda
COX-2 inhibition as a chemopreventive strategy - from premise to promise |
| 11:50-12:30 | Stephen D. Hursting, NCI, NIH, Bethesda
Mechanism-based cancer prevention approaches: Targets, examples and the use of transgenic mice |
Monday Evening
Feb 21st | Molecular Epidemiology: Gene-Environment Interactions |
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| 7:30-7:45 | Introduction by Discussion Leader, Robert W. Haile, USC, Los Angeles |
| 7:45-8:20 | Margaret R. Spitz, UT M.D. Anderson Cancer Center, Houston
Molecular epidemiology of lung cancer |
| 8:20-8:55 | Christine Ambrosone, National Center for Toxicological Research, Jefferson, Arkansas
Use of molecular epidemiology to explore paradigms of carcinogenesis in hormonally-responsive tissue |
| 8:55-9:10 | Break |
| 9:10-9:45 | John Potter, Fred Hutchinson Cancer Research Center, Seattle
Colorectal neoplasia: at the interface of population and molecular biology |
Tuesday Morning
February 22nd | DNA Methylation I |
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| 9:00-9:15 | Introduction by Discussion Leader, Art Riggs, City of Hope & Beckman Research Institute |
| 9:15-10:00 | Peter Jones, USC, Los Angeles
Control of de novo methylation in the cell cycle |
| 10:00-10:45 | Rudolf Jaenisch, Whitehead Institute, MIT, Boston
DNA methylation, cell death and cancer |
| 10:45-11:00 | Coffee Break |
| 11:00-11:45 | Paul Goodfellow, Washington University, St. Louis
hMLH1 silencing by methylation in endometrial cancers |
| 11:45-12:30 | Gerd Pfeifer, City of Hope & Beckman Research Institute, Los Angeles
Cytosine methylation determines hot spots of DNA damage in the human p53 gene |
Tuesday Evening
February 22nd | Genomic Imprinting |
|
| 7:30-7:40 | Introduction by Discussion Leader, Peter Jones, USC, Los Angeles |
| 7:40-8:10 | Michael J. Higgins, Roswell Park Cancer Institute, Buffalo
Chromosome 11p15 Imprinting and Beckwith-Wiedemann Syndrome |
| 8:10-8:40 | Rosanna Weksberg, University of Toronto
Overgrowth syndromes and tumor predisposition |
| 8:40-8:50 | Break |
| 8:50-9:20 | Piroska Szabó, City of Hope & Beckman Research Institute, Los Angeles
Genomic footprinting analysis of the differentially methylated region of the mouse H19 gene |
| 9:20-9:50 | Joern Walter, Max-Planck Institute, Berlin
Reprogramming of gametic methylation in the mammalian zygote |
Wednesday Morning
February 23rd | DNA Repair & Apoptosis |
|
| 8:55-9:05 | Announcements by Bill Bennett, City of Hope & Beckman Research Institute, Los Angeles |
| 9:05-9:20 | Introduction by Discussion Leader, Ted Krontiris, City of Hope & Beckman Research Institute |
| 9:20-10:05 | John Petrini, University of Wisconsin, Madison
Checkpoints, NBS and Rad52 epistasis group |
| 10:05-10:50 | Guru Reddy, Pangene Corporation, Mt. View, CA
Rad51 inhibitors for chemo- and radio-sensitization of tumors |
| 10:50-11:00 | Coffee Break |
| 11:00-11:45 | Paul Russell, Scripps Institute, La Jolla
Chk1/Cdc25 pathway at the DNA repair "checkpoint" |
| 11:45-12:30 | Frank McKeon, Harvard Medical School, Boston
Checkpoint functions & the p53 family |
Wednesday Afternoon
February 23rd | Rett Syndrome Workshop (optional) |
|
| 2:00-5:00 | Ignatia Van de Veyver, Baylor College of Medicine, Houston |
| Sakkubai Naidu, Kennedy Krieger Institute, Baltimore |
| Alan Wolffe, NICHD, NIH, Bethesda |
| Tim Bestor, Columbia University, New York |
Wednesday Evening
February 23rd | Chromosomes & Chromatin |
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| 7:30-7:45 | Introduction by Discussion Leader, Alan Wolffe, NICHD, NIH, Bethesda |
| 7:45-8:20 | Alan Wolffe, NICHD, NIH, Bethesda
Cancer epigenetics: biochemical mechanisms that connect DNA methylation, chromatin remodeling, histone deacetylation and transcription |
| 8:20-8:55 | Martin Smith, Indiana University Cancer Center, Indianapolis
Chromatin changes with mutant p53 and loss of cell cycle control |
| 8:55-9:10 | Break |
| 9:10-9:45 | Mat Thayer, Oregon Health Sciences University, Portland
ATR, DNA damage sensing & chromosome structure/rhabdomyosarcoma |
Thursday Morning
February 24th | DNA Methylation II |
|
| 9:00-9:15 | Introduction by Discussion Leader, Ben Tycko, Columbia University, New York |
| 9:15-10:00 | Steve Baylin, Johns Hopkins University, Baltimore
The role of promoter regions in gene silencing in cancer |
| 10:00-10:45 | Sandy Markowitz, Case Western Reserve University, Cleveland
DNA repair genes and TGF-b receptors, coupled targets in colon carcinogenesis |
| 10:45-11:00 | Coffee Break |
| 11:00-11:45 | Tim Bestor, Columbia University, New York
DNA methylation and hypomethylating genetic syndromes |
| 11:45-12:30 | Melanie Ehrlich, Tulane University, New Orleans
The ICF syndrome & cancer: DNA hypomethylation & chromosomal rearrangements |
Thursday Evening
February 24th | Molecular Biology of BRCA1 & BRCA2 |
|
| 7:30-7:40 | Introduction by Discussion Leader, Richard Baer, Columbia University, New York |
| 7:40-8:10 | Richard Baer, Columbia University, New York
Novel BRCA1 and BRCA2 interacting proteins |
| 8:10-8:40 | Ralph Scully, Harvard Medical School, Boston
Functional analysis of BRCA1 |
| 8:40-8:50 | Break |
| 8:50-9:20 | Jeff Parvin, Harvard Medical School, Boston
Transcription function of BRCA1 |
| 9:20-9:50 | Tom Ludwig, Columbia University, New York
Analysis of BRCA1, BRCA2 in a murine knockout model |
