Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Translating Cancer Genetics and Epigenetics to Therapy
7:40 pm - 8:10 pm
"The Role of Transcriptional Cyclin Dependent Kinases in Oncology"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Tet Enzymes in Malignancy"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Translating Cancer Genomics to Clinical Care"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Non-Coding Genome and Cancer
9:00 am - 9:25 am
"Personal Regulome Navigation of Cancer"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Transcriptional Coactivator PGC-1α Provides a Conduit Between DNA-Associated and RNA-Associated Proteins"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
10:25 am - 10:30 am
Discussion
10:30 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"An Intronic Deletion Triggering a Mitotic Oncogene"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Long Noncoding RNA Associated with Aberrant LKB1 Signaling"
11:30 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Large-Scale Mechanistic Analysis of Tumor Evolution in Livers of Five Rodents"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
The Cancer Epitranscriptome
6:00 pm - 6:25 pm
"RNA m6A Methylation in Human Cancer"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"The Role of RNA Modifications in Cancer"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"miRNAs in Viral Oncogenesis"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Transposable Elements in the Normal and Cancer Epigenome"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Epigenetic and Genetic Mechanisms
9:00 am - 9:20 am
"Structure and Function of Mammalian SWI/SNF Complexes in Cancer"
9:20 am - 9:25 am
Discussion
9:25 am - 9:45 am
"Epigenetic Regulation of Repetitive Elements in Cancer"
9:45 am - 9:50 am
Discussion
9:50 am - 10:10 am
"Epigenetic Regulation of Carcinogen Susceptibility"
10:10 am - 10:15 am
Discussion
10:15 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"DNA Methylation Canyons Guide Long-Range Chromosomal Interactions"
11:00 am - 11:05 am
Discussion
11:05 am - 11:25 am
"Flanking Sequence Preferences of the DNMT3A R882H AML Mutation Affect Cellular DNA Methylation Patterns"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Novel DNA Methylation in Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"A Reassessment of N6-Methyladenine in Mammalian DNA"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Histone and DNA Methylation Crosstalk in Developmental and Neoplastic Overgrowth"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Functional Studies of the Cancer Genome and Epigenome
6:00 pm - 6:25 pm
"Cohesin Complexes in Myeloid Malignancies"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Mapping the Genetic Landscape of Human Cells"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Functional Genomic Characterization of Epigenetic Dependencies in Myeloma"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Modifications of RNA: Their Function and Role in Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
The Genetics and Epigenetics of Lymphoma and Immuno-Oncology
9:00 am - 9:25 am
"Epigenetic Mechanisms of Lymphomagenesis"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Structural and Functional Modifications of the 3D Organization of the Genome in Non-Hodgkin Lymphoma"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"An Early Myc-Dependent Transcriptional Program Underlies Enhanced Macromolecular Biosynthesis and Cell Growth During B-Cell Activation"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"The Molecular Underpinnings for Enhancing Immune Checkpoint Therapy with Combinatorial Epigenetic Therapy"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
"Epigenetic Therapy and Endogenous Retroviruses"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:25 pm
"Decoding Differentiation States in Immune Cells and T Cell Dysfunction in Tumors"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Genome-Wide Studies of Epigenetics and Cancer
6:00 pm - 6:25 pm
"Identifying the Noncoding Genetic Drivers of Cancer from Epigenetics"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Epigenetic Fields Induced by Chronic Inflammation: Mechanism of Formation and Clinical Impact"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Targeting Polycomb Group Proteins in Prostate Cancer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Single Cell Whole Genome Sequencing for Population Genetic Inference of Cancer Dynamics"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Computational Approaches and Genome-Wide Approaches to Cancer Genetics and Epigenetics
9:00 am - 9:25 am
"Systematic Identification of Synergistic Regulators as Targets for Combination Therapy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
" Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers that May Predispose to Leukemia"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"CTCFL and Its Impact on Gene Regulation and Interplay with CTCF Function"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Fixing ChIP with Next-Generation Spike-in Controls"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
"Mutant p53 Controls Epigenetic Program Promoting Cancer"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
"A Role for Nuclear PP2A in Transcriptional Regulation"
11:50 am - 11:55 am
Discussion
11:55 am - 12:05 pm
"Marrying Drug-Induction of Viral Mimicry, the Inflammasome and DNA Repair Defects in Cancer"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:20 pm
"A Mutation in the Core of Histone H2B Represents a New Class of Oncogenic Drivers"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cancer and the 4D Nucleome
6:00 pm - 6:25 pm
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Decoding Genome-Scale Epigenetic Alterations in Cancer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:40 pm
"Exploring Complete Chromatin Architecture"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure