Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Integrative Cancer Genetics and Epigenetics in Precision Cancer Therapy
7:40 pm - 8:10 pm
"Retrotransposon in Cancer: The Marker and the Mutator"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:45 pm
"Drivers of Tumor Cell Immortality and Early Clonal Expansions"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Histone Mutations as Cancer Drivers"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cancer and Non-Coding Genome
9:00 am - 9:25 am
"Histone Mutations in Disease: From Cancer and Beyond"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Oncogenic Reactivation of Young L1s is a Hallmark of Colon Cancer"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"New Single-Cell Tools to Study Cancer 'Epigenetics'"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Epigenomic Dysregulation of Retrotransposons in Human Diseases"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Simultaneous Characterisation of Somatic Genomic and Epigenomic Mutations in Clinical Research Samples Using a Single Nanopore Sequencing Assay"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Wilms’ Tumor 1 Functions as a Tumor Suppressor to Suppress FLT3-STAT Signaling and Epigenetic Remodeling in Acute Myeloid Leukemia"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Technologies to Interrogate Cancer Genome, Epigenome and 3D Chromatin
6:00 pm - 6:25 pm
"Genomic Technologies for Extrachromosomal Circular DNA (ecDNA) Structure and Function Analyses"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Extensive Enhancer and Silencer Rewriting in AML."
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Oncogenic Evolution of Chromatin 3D Structure"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Alterations in Chromatin Looping and Enhancer Function in Acute Myeloid Leukemia"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Transposable Elements and Immune Response
9:00 am - 9:25 am
"Targeting Transposable Elements to Reverse Immune Evasion in Cancer"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Graph Genomes Reveal Missing Signal in Epigenomic Data"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Transposable Element Activation in Cohesin-Mutant Myeloid Malignancies"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"KRAB Zinc Finger Proteins Protect Cancer Cells from Transposon-Driven Genotoxic Stress"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Gene Regulation by Transposable Elements in Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Nucleosome Conformation Dictates the Histone Code"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Intratumoral Heterogeneity
6:00 pm - 6:25 pm
"Rerunning Tumour Evolution Reveals Germline Influences Cancer Susceptibility"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Dissecting Gene Regulatory Circuits with Single-cell Epigenomics"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"Mechanisms of Cell Plasticity in Breast Cancer"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Sleepwalking Through Evolution: A Tale of Dormancy and Hormone-Dependent Breast Cancer"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Heterogeneity in Chromatin States Define a Disease Spectrum in Synovial Sarcoma"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Role of DNMT3A in Cancer"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Fill the Gap Between Cancer Omics Data and Precision Cancer Medicine."
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Global Analysis of Transcriptome and its Interaction with Chromatin in the FANTOM6 Project"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Single-Cell Multiome Profiling from the coopERA trial: a Window into the Response to Endocrine Therapies in Early ER+ Breast Cancer"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"VAI-SU2C Epigenetics Dream Team: Synergistic Potential of Epigenetic Therapy and Immunotherapy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Targeting Epigenetic Vulnerabilities in H3K27-altered Diffuse Midline Glioma"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Genome Wide Integrative Spatio-Functional Genomics Using Novel Bifunctional Nicking Enzyme Reveals NPM1 as a Transcription Factor"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Beyond the Tumor Cells: Microenvironment and Macroenvironment
6:00 pm - 6:25 pm
"3D Chromatin Structure at the Intersection of Toxicology and Disease."
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"Enhancer Reprogramming Drives an Epigenomic Risk Network for Liver Tumorigenesis"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:25 pm
"DNA Methylation Reprogramming in Mammals"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Epigenetic Field with Epithelial and Stromal Cells Predicts Cancer Risk"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translational Epigenetics: Detection and Therapy
9:00 am - 9:25 am
"Epigenetic Therapy and Immunotherapy"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
"Epigenetic Therapy Disrupts the 3D Epigenome"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
"Some Approaches to Targeting the Cancer Epigenome for Therapy and Biomarkers"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
"Oncogenic Non-coding Genes Activated by Distal Enhancers through Somatic Genome Rearrangements in Cancer"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
"The Unique Transcriptomic Landscape Behind the Aggressiveness of Breast Cancer in Young Women"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"Aberrant Non-canonical NF-kB Signalling Reprograms the Epigenome Landscape to Drive Oncogenic Transcriptomes in Multiple Myeloma"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Clustered Pattern of Transcription Factor Binding Reveals Phase-Separated Transcriptional Condensates at Super-Enhancers"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Exploiting Chromatin Variants to Understand Prostate Cancer Oncogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Development of a Complete, End-to-End, Automated Single-Cell System for Biomarker Discovery."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cancer Genome, Epigenome and Epi-Transcriptome Engineering
6:00 pm - 6:25 pm
"Engineering at Chromatin Variants to Modulate Self-Renewal in Leukemia"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:55 pm
"TET Mediated Epigenetic Regulation in Cancer and Aging"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
"Defining the Locus-Specific Landscape of Transposon Expression in Cancers"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
"Targeting KAT6A/KAT6B Dependencies in Breast Cancer with a Novel Selective, Orally Bioavailable KAT6 Inhibitor, CTx-648/PF-9363"
7:25 pm - 7:30 pm
Discussion
7:30 pm - 7:55 pm
"Dual Function of MEN1 in Regulating Repeat Expression and Tumor-Microenvironment Interactions"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure