Technological Innovations to Elucidate Cancer Progression and Treatment

May 20 - 21, 2023

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

The Cancer Genetics and Epigenetics GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

Technological innovation drives cancer research. This meeting will feature early-career scientists who will highlight exciting single-cell/spatial-omic, metabolomic, and computational technologies. The meeting will provide a forum for early-career researchers to share their scientific inspirations, struggles, and successes in technology development and career decision-making. Through interactive forums and poster sessions, we hope to inspire meaningful collaborations and thought-provoking conversations that not only advance cancer genetic and epigenetic research but also the careers of young scientists.

Related Meeting

This GRS will be held in conjunction with the "Cancer Genetics and Epigenetics" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm	Keynote Session: Leveraging Spatial-Omics for Cancer Treatment Discussion Leader:
3:15 pm - 3:35 pm	"Leveraging Spatial-Omics for Cancer Treatment"
3:35 pm - 3:45 pm	Discussion
3:45 pm - 3:55 pm	"DNA Polymerase Epsilon Variants Generate Distinct Mutational Landscape in Endometrial Cancer Genomes"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Development and Implementation of "-omics" Technology Discussion Leader:
5:30 pm - 5:40 pm	"Targeting Circular DNA Biogenesis in Cancer"
5:40 pm - 5:45 pm	Discussion
5:45 pm - 5:55 pm	"Total RNA Profiling at Single-Cell Resolution"
5:55 pm - 6:00 pm	Discussion
6:00 pm - 6:10 pm	"Integrative Single-Nucleus and Spatial Analysis Maps the Tumor Environment of Fibrolamellar Carcinoma"
6:10 pm - 6:15 pm	Discussion
6:15 pm - 6:25 pm	"Cancer-Specific Alternative Polyadenylation Shapes Tumor Phenotypes in vivo"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Regulation of Cell Cycle by Stop Codon Readthrough of FEM1B"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Multifactorial Profiling of Epigenetic Landscapes at Single-Cell Resolution"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"The Role of Transposable Elements as Oncogenic Enhancers in Cohesin-Mutant Myeloid Malignancies."
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Long-Range Continuous Mutagenesis of Endogenous Genomes"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Technology-Driven Translational Approaches for Cancer Therapy Discussion Leader:
9:00 am - 9:10 am	"Leveraging CRISPR Screening for a Deeper Understanding of Human Malignancy"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Dynamic Regulation of Transposable Elements During Malignant Transformation"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Integrative PTEN Enhancer Discovery Reveals a New Model of Enhancer Organization"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Cellular Memory and Adaptive Resistance in Metastatic Melanoma"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Human Pluripotent Stem Cells-Based Models to Address Oncogenic Competence"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Targeting LSD1 Rescues MHC-I Antigen Presentation and Overcomes Resistance to PD-L1 Checkpoint Blockade in Small Cell Lung Cancer"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"DNMT and HDAC Inhibition Induces Immunogenic Neoantigens From Human Endogenous Retroviral Element-derived Transcripts"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"The Tumor Mycobiome"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Maximizing Success: Technology Development, Career Trajectory, and Work-Life Balance Discussion Leader:
1:30 pm - 1:40 pm	"A cfDNA Methylation Tissue-of-Origin Classifier for Cancer of Unknown Primary"
1:40 pm - 1:45 pm	Discussion
1:45 pm - 1:55 pm	"Differentiation-Focused CRISPR Screens Identify LSD1i-based Combination Therapy Target That Induces Terminal Differentiation in AML"
1:55 pm - 2:00 pm	Discussion
2:00 pm - 2:30 pm	Panel Discussion Maximizing Success: Technology Development, Career Trajectory, and Work-Life Balance
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Funding for this conference was made possible (in part) by 1R13CA281326-01 from the National Cancer Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Cancer Genetics and Epigenetics