| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| Chair's introduction |
| 7:30 pm - 9:30 pm | Oncogenic signaling and its therapeutic modulation |
| Discussion Leader: Gary Gilliland (Brigham & Womens Hospital, Boston) |
| 7:30 pm - 8:10 pm | David Tuveson (U Penn, Philadelphia)
"The KRAS oncogene initiates neoplasia" |
| 8:10 pm - 8:50 pm | Mariano Barbacid (CNIO, Madrid, Spain)
"The role of cyclin-dependent kinases in normal and malignant cell proliferation" |
| 8:50 pm - 9:30 pm | Loren Walensky (Dana-Faber Cancer Institute)
"Targeting Apoptosis in Cancer using Hydrocarbon-Stapled Helices of the BCL-2 Family" |
| 9:30 pm | Reception |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Oncogenic signaling and its therapeutic modulation |
| Discussion Leader: Mariano Barbacid (CNIO, Madrid, Spain) |
| 9:00 am - 9:40 am | Matthias Hebrok (UCSF)
"Pancreatic Hedgehog signalling: from development to disease" |
| 9:40 am - 10:00 am | Short talk: Brian Lewis (U Mass, Worcester)
"The initiating oncogenic lesion determines pancreatic tumor type" |
| 10:00 am | Group photo & Coffee Break |
| 10:50 am - 11:30 am | Gary Gilliland (Brigham & Womens Hospital, Boston)
"Genetics of leukaemia: therapeutic implications" |
| 11:30 am - 12:10 pm | Constantine Mitsiades (Dana-Farber Cancer Institute)
"Inhibition of IGFs/IGF-1R signaling: molecular sequelae and therapeutic implications for hematologic malignancies and solid tumors" |
| 12:10 pm - 12:30 pm | Short talk: Jackie Papkoff (Diadexus, Inc.)
"Discovery and Characterization of a Novel Membrane Protein over-expressed in Human Breast and Ovarian Carcinomas: A Promising New Target for Therapeutic Monoclonal Antibodies" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Angiogenesis |
| Discussion Leader: Richard Kolesnick (Memorial Sloan-Kettering, NY) |
| 7:30 pm - 8:10 pm | Raghu Kalluri (Harvard Medical School)
"Endogenous inhibitors of angiogenesis are tumor suppressors" |
| 8:10 pm - 8:50 pm | Gabriele Bergers (UCSF)
"Stage & tissue - specific regulation of angiogenesis" |
| 8:50 pm - 9:30 pm | Robert Kerbel (University of Toronto)
"Metronomic basis for anti-angiogenic therapy" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cell-cell interactions & metastasis |
| Discussion Leader: Sara Courtneidge (van Andel Institute) |
| 9:00 am - 9:40 am | Richard Kolesnick (Memorial Sloan-Kettering Cancer Institute, NY)
"The role of microvascular dysfunction in the tumor response to radiation therapy" |
| 9:40 am - 10:20 am | Fiona Watt (Cancer Research UK London Research Institute)
"Contribution of stem cells & differentiated cells to epidermal tumour formation" |
| 10:20 am | Coffee break |
| 11:00 am - 11:40 am | Tian Xu (Yale University)
"Genetic screens in Drosophila for tumor progression" |
| 11:40 am - 12:30 pm | Short talks & discussion |
| Steven Skapek (St. Jude Children's Research Hospital)
"The Arf tumor suppressor is required for vascular regression during eye development" |
| Jing Yang (Whitehead Institute)
"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis" |
| Phil Jones (MRC, Cambridge)
"Hes6 is a candidate oncogene in Rhabdomyosarcoma (RMS)" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Cell-cell interactions & metastasis |
| Discussion Leader: Fiona Watt (Cancer Research UK, London) |
| 7:30 pm - 8:10 pm | Sara Courtneidge (Van Andel Institute, Michigan)
"SRC & its substrate FISH in invasion & metastasis" |
| 8:10 pm - 8:50 pm | Erik Sahai (Young University)
"Mechanisms of tumor cell invasion: Role of RhoGTPases and ROCKs" |
| 8:50 pm - 9:30 pm | Senthil Muthusamy (Cold Spring Harbor Labs, NY)
"ErbB2 Induced Transformation of Polarized Epithelial cells" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Tumor suppressor networks |
| Discussion Leader: David Livingston (Dana-Farber Cancer Institute) |
| 9:00 am - 9:40 am | Scott Lowe (Cold Spring Harbor Labs, NY)
"Deconstructing tumor suppressor networks" |
| 9:40 am - 10:20 am | Rene Bernards (Netherlands Cancer Institute, Amsterdam)
"Functional gene identification in mammalian cells using high throughput RNAi screens" |
| 10:20 am | Coffee break |
| 11:00 am - 11:40 am | Pier-Paolo Pandolfi (Memorial Sloan-Kettering Institute, NY) |
| 11:40 am - 12:30 pm | Short talks & discussion |
| James F. Amatruda (Department of Hematology/Oncology, Children's Hospital, Boston)
"Identifying Cancer Genes Through Forward Genetic Screens in the Zebrafish" |
| Klaudia M. Dobrzycka
"SAFB1 As A Novel Tumor Suppressor Gene in Breast Cancer" |
| Yasumichi Hitoshi (Rigel Inc., San Francisco)
"Phenotypic effects of Aurora kinase inhibitors" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 8:10 pm | Business meeting; Election of 2005 Vice-Chair |
| 8:10 pm - 9:30 pm | Tumor suppressor networks |
| Discussion Leader: Pier-Paolo Pandolfi (Memorial Sloan-Kettering) |
| 8:10 pm - 8:50 pm | Mike Tyers (University of Toronto)
"Coupling of growth and division" |
| 8:50 pm - 9:30 pm | Paul Krimpenfoort (Netherlands Cancer Institute, Amsterdam)
"Mouse models of cancer" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Mitotic cell cycle control & genome instability |
| Discussion Leader: Hideyuki Saya (Kumamoto University, Japan) |
| 9:00 am - 9:40 am | Don Cleveland (UCSD)
"Guarding the genome: the mitotic checkpoint, aneuploidy & cancer" |
| 9:40 am - 10:20 am | Junjie Chen (Mayo Clinic)
"G2/M checkpoint controls and tumorigenesis" |
| 10:20 am | Coffee Break |
| 11:00 am - 11:40 am | David Livingston (Dana-Farber Cancer Institute)
"Functional Analysis of the BRCA1 Gene Product" |
| 11:40 am - 12:30 pm | Short talks & discussion |
| Rui-Hong Wang (National Cancer Institute, Bethesda)
"Breast Cancer Associated Gene 1 (BRCA1) Plays a Critical Role in the Spindle Checkpoint Through Regulating Mad2" |
| Kyungjae Myung (National Human Genome Research Institute, Bethesda)
"Complex mechanisms of gross chromosomal rearrangements" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Mitotic cell cycle control & genome instability |
| Discussion Leader: Don Cleveland (UCSD) |
| 7:30 pm - 8:10 pm | Hideyuki Saya (Kumamoto University, Japan)
"Roles of Auroura-A kinase in mitotic progression" |
| 8:10 pm - 8:50 pm | Dario Altieri (University of Massachusetts Memorial Cancer Center)
"Survivin checkpoints" |
| 8:50 pm - 9:30 pm | Wei Gu (Columbia University)
"Dynamics of the p53 pathway" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
