| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:20 pm - 7:30 pm | Chair's introduction |
| 7:30 pm - 9:30 pm | mRNA Translation, Nucleolar Network, Ribosome and Cancer I |
| Discussion leader: Jacqueline Lees |
| 7:30 pm - 8:00 pm | Jacqueline Lees (MIT)
"Cancer screens in zebrafish reveal ribosomal proteins as tumor suppressors" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Jason Weber (Washington University)
"Interpretation of oncogenic signals by the nucleolus" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | George Thomas (Univ. of Cincinnati)
"Nutritional sensing in the mTOR/S6K1 pathway" |
| 9:20 pm - 9:30 pm | Discussion |
| 9:30 pm | Welcome Event |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:30 am - 11:20 am | mRNA Translation, Nucleolar Network, Ribosome and Cancer II |
| Discussion leader: Jacqueline Lees |
| 9:00 am - 9:30 am | David M. Sabatini (MIT)
"Regulation of growth by the mTOR pathway" |
| 9:30 pm - 9:40 pm | Discussion |
| 9:40 am - 10:25 am | Selected talks and discussion: |
| Short Talk: Tokuhiro Chano (Shiga University)
"RB1CC1 is involved in the TSC-mTOR pathway, and regulates the cell cycle and size" |
| Short Talk: Todd Waldman (Georgetown)
"Targeted deletion of Pten reveals a radiation-induced size checkpoint in human cancer cells" |
| Short Talk: Li Ma (Sloan-Kettering)
"Role of TSC2 in tuberous sclerosis (TSC) and cancer pathogenesis" |
| 10:25 am - 10:40 am | Break |
| 10:40 am - 11:10 am | Lewis Cantley (Harvard)
"PI 3-kinase and cancer" |
| 11:10 am - 11:20 am | Discussion |
| 11:20 am - 12:30 pm | Stem Cell and Cancer Stem Cell I |
| Discussion Leader: Toshio Suda |
| 11:20 am - 11:50 am | George Daley (Harvard)
"In vitro screens for target-directed drug resistance" |
| 11:50 am - 12:00 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Stem Cell and Cancer Stem Cell II |
| Discussion Leader: Toshio Suda |
| 7:30 pm - 8:00 pm | Toshio Suda (Keio University)
"Exhaustion of hematopoietic stem cells in response to reactive oxygen species" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Michael Clarke (Univ. of Michigan) |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Len Zon (Harvard)
"Use of the zebrafish to study cancer" |
| 9:20 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Cooperative Tumorigenesis and Tumor Maintenance |
| Discussion leader: Ron DePinho |
| 9:00 am - 9:30 am | Peter Sicinski (Harvard)
"Cell cycle machinery in development and in cancer" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Selected talk and discussion: |
| Short Talk: Zhe Li (Childrens Hospital-Boston)
"A mouse model of human t(12;15) (TEL-NTRK3) translocation and breast cancer" |
| 9:55 am - 10:25 am | Dean Felsher (Stanford)
"Reversing oncogene induced tumorigenesis" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 10:50 am | Break |
| 10:50 am - 11:20 am | Eric Holland (Sloan-Kettering)
"Pleiotropic effects of oncogenic signaling in gliomagenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:00 pm | Ron DePinho (Harvard)
"Genetics and biology of pancreatic cancer" |
| 12:00 pm - 12:10 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Oncogenes, Tumor Suppressors and Modifiers I |
| Discussion leader: Terry Van Dyke |
| 7:30 pm - 8:00 pm | Terry Van Dyke (Univ. of North Carolina)
"Complex tumor suppressor interactions during cancer evolution" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Nicholas La Thangue (Univ. of Oxford)
"New levels of control in the p53 response" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | René Bernards (Netherlands Cancer Institute)
"Identification of cancer relevant genes using functional genetic screens" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 9:55 am | Oncogenes, Tumor Suppressors and Modifiers II |
| Discussion leader: Nicholas La Thangue |
| 9:00 am - 9:30 am | Bill Kaelin (Harvard)
"The von Hippel-Lindau gene and kidney cancer" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Selected talk and discussion: |
| Short Talk: Menno Cregyhton (Netherlands Cancer Institute)
"Functional identification of specific PP2A oloenzyme activity towards cancer relevant pathways using a small family knock down library" |
| 9:55 am - 11:45 am | Microenvironment and Metastasis |
| Discussion leader: Harold Moses |
| 9:55 am - 10:25 am | William Hahn (Harvard)
"Cooperating interactions in transformation" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 10:50 am | Selected talk and discussion: |
| Short Talk: Gaorav Gupta (Sloan-Kettering)
"Breast cancer lung metastasis genes" |
| 10:50 am - 11:05 am | Break |
| 11:05 am - 11:35 am | Harold Moses (Vanderbilt University)
"Stromal and epithelial TGF-ß signaling in cancer" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:30 pm | Senescence, Telomeres and Cancer I |
| Discussion leader: Jerry Shay |
| 11:45 am - 12:15 pm | Fabrizio d'adda di Fagagna (IFOM Foundation)
"DNA-damage checkpoint response and cellular senescence" |
| 12:15 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Dinner |
| 7:30 pm - 9:05 pm | Senescence, Telomeres and Cancer II |
| Discussion leader: Daniel Peeper |
| 7:30 pm - 8:00 pm | Daniel Peeper (Netherlands Cancer Institute)
"Oncogene-induced senescence: in-vitro tool or in-vivo reality?" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:25 pm | Selected talk and discussion: |
| Short Talk: Zhenbang Chen (Sloan-Kettering)
"Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis" |
| 8:25 pm - 8:55 pm | Jerry Shay (University of Texas)
"Role of telomeres and telomerase in cancer" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:30 pm | Business Meeting |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 11:30 am | Transcription, Epigenetic Control and Cancer |
| Discussion leader: Stephen Baylin |
| 9:00 am - 9:30 am | Ari Melnick (Albert Einstein)
"Transcriptional repression of epigenetically silenced tumor suppressors" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Maarten Van Lohuizen (Netherlands Cancer Institute)
"Polycomb repressors controlling stem cell fate: implications for cancer and development" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:35 am | Break |
| 10:35 am - 10:50 am | Selected talk and discussion: |
| Short Talk: Kurt Krummel (Salk Institute)
"Mouse bites dogma: New insights into the control of p53 activation and degradation from in vivo models" |
| 10:50 am - 11:20 am | Stephen Baylin (Johns Hopkins)
"Epigenetic gene silencing - are networks of genes involved and implications for early tumor progression" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 12:30 pm | Mitotic Cell Cycle Control and Genomic Instability I |
| Discussion leader: Fred Alt |
| 11:30 am - 11:45 am | Selected talk and discussion: |
| Short Talk: Silvia Grisendi (Sloan-Kettering)
"Role of NPM in the control of genetic stability and tumorigenesis" |
| 11:45 am - 12:15 pm | Prasad Jallepalli (Sloan-Kettering)
"Sister acts: regulation of chromosome dynamics in human cells by the Separase/Securin complex" |
| 12:15 pm - 12:25 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session IV |
| 6:00 pm | Lobster Dinner |
| 7:30 pm - 9:30 pm | Mitotic Cell Cycle Control and Genomic Instability II |
| Discussion leader: Prasad Jallepalli |
| 7:30 pm - 8:00 pm | Ashok Venkitaraman (MRC)
"Cancer susceptibility and the functions of the BRCA2 tumor suppressor" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:55 pm | Selected talks and discussion: |
| Short Talk: David Pellman (Harvard)
"Tetraploidy leading to aneuploidy can initiate tumorigenesis in p53-/- mammary epithelial cells" |
| Short Talk: Sebastian Nijman (Netherlands Cancer Institute)
"Functional annotation of deubiquitinating enzymes using RNA interference" |
| Short Talk: Katya Ravid (Boston University)
"Induction of eneuploidy and transformation properties by a stable form of Aurora-B kinase" |
| 8:55 pm - 9:25 pm | Fred Alt (Harvard)
"The DNA DSB response: role in suppression of translocations and lymphomas" |
| 9:25 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
