| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Chair's introduction |
| 7:40 pm - 8.50 pm | Keynote lecture |
| 7:40 pm - 8.40 pm | Pier Paolo Pandolfi (Memorial Sloan Kettering)
"Cancer: Models & Mechanisms" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:30 pm | Self Sufficiency in growth signals I |
| Discussion leader: Scott Lowe (Cold Spring Harbor) |
| 8:50 pm - 9:20 pm | Scott Lowe (Cold Spring Harbor)
"Evading p53 action during tumorigenesis" |
| 9:20 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 11:05 am | Self Sufficiency in growth signals II |
| Discussion leader: Scott Lowe (Cold Spring Harbor) |
| 9:00 am - 9:30 am | Carol Prives (Columbia University)
"Regulation of the transcriptional activity of the p53 tumor suppressor protein" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Daniel Peeper (Netherlands Cancer Institute)
"Exploiting senescence and anoikis: functional cloning of tumor and metastasis genes" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:05 am | Short talk: Kevin Haigis (MIT)
"Pleiotropic effects of activating K-ras in the colonic epithelium" |
| 11:05 am - 12:30 pm | Insensitivity to anti-growth signals I |
| Discussion leader: Lewis Chodosh (Cancer Genetics) |
| 11:05 am - 11:35 am | Lewis Chodosh (Cancer Genetics)
"Tumor Progression in Mouse Models for Breast Cancer" |
| 11:35 am - 11:45 am | Discussion |
| 11:45 am - 12:00 pm | Short talk: Al Charest (MIT)
"ROS Fusion Tyrosine Kinase Activates a SHP-2/P13K/mTOR Signaling Axis to form Glioblastoma in Mice" |
| 12:00 pm - 12:15 pm | Short talk: Xin-Hua Feng (BCM)
"PPM1A functions as a Smad phosphatase to terminate TGFß signaling" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session I |
| 6:00 pm | Dinner |
| 7:30 pm - 8:00 pm | Insensitivity to anti-growth signals II |
| Discussion leader: Lewis Chodosh (Cancer Genetics) |
| 7:30 pm - 7:45 pm | Short talk: David MacPherson (Carnegie Institution)
"Murine bilateral retinoblastoma exhibiting rapid onset, metastatic progression and N-myc gene amplification" |
| 7:45 pm - 8:00 pm | Short talk: Raya H Saab (St. Jude Children Research Hospital)
"p53-dependent suppression of pineoblastoma development in Irbp-Cyclin Dl transgenic mice: a model for primitive neuroectodermal brain tumors" |
| 8:00 pm - 9:30 pm | Tissue invasion and metastasis I |
| Discussion leader: Joan Massague (Sloan-Kettering Institute) |
| 8:00 pm - 8:30 pm | Joan Massague (Sloan-Kettering Institute)
"Site-specific metastasis genes and functions" |
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:10 pm | Harold Moses (Vanderbilt Stallworth)
"Tumor Suppression by TGF-beta" |
| 9:10 pm - 9:20 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 9:55 am | Tissue invasion and metastasis II |
| Discussion leader: Joan Massague (Sloan-Kettering Institute) |
| 9:00 am - 9:30 am | David Lyden (Weill Medical College, Cornell University)
"Setting the Stage: The Pre-Mestastatic Niche" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 9:55 am | Short talk: Jackie Papkoff (CFD Therapeutics, Inc.)
"Discovery and validation of a promising new target for therapeutic monoclonal antibodies: a type II transmembrane serine protease overexpressed in human ovarian and pancreatic cancers" |
| 9:55 am - 12:30 pm | Limitliss replicative potential |
| Discussion leader: Bill Hahn (Harvard) |
| 9:55 am - 10:25 am | Bill Hahn (Harvard)
"Dissecting cooperative interactions in transformation" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am - 10:55 am | Coffee Break |
| 10:55 am - 11:10 am | Short talk: Roderik Kortlever (Netherlands Cancer Institute)
"Plasminogen activator inhibitor l is a critical p53 target in the induction of replicative senescence" |
| 11:10 am - 11:40 am | Jerry Shay (University of Texas)
"Role of telomeres in replicative senescence and telomerase in limitless replicative potential" |
| 11:40 am - 11:50 am | Discussion |
| 11:50 am - 12:20 pm | Ron DePinho (Harvard)
"FoxOs in Cancer & Aging" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 6:00 pm | Free Time / Excursion to Newport |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Sustained angiogenesis |
| Discussion leader: Bill Kaelin (Harvard) |
| 7:30 pm - 8:00 pm | Bill Kaelin (Harvard)
"Functions of the VHL Tumor Suppressor Gene" |
| 8:00 pm - 8.10 pm | Discussion |
| 8:10 pm - 8:40 pm | Laura Benjamin (BIDMC)
"Rapamycin inhibition of vascular Akt signalling and tumor growth" |
| 8:40 pm - 8.50 pm | Discussion |
| 8:50 pm - 9:20 pm | Napoleone Ferrara (Genentech, Inc.) |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Evading apoptosis |
| Discussion leader: Gerard Evan (UCSF) |
| 9:00 am - 9:30 am | Louis Staudt (National Cancer Institute)
"RNA interference screens for new molecular targets in cancer" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Gerard Evan (UCSF)
"Uses and abuses of apoptosis in tumor suppression" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:05 am | Short talk: Susanne Schlisio (Harvard)
"Neuronal Apoptosis by EglN3 - Oxygen Sensing and Cancer" |
| 11:05 am - 11:20 am | Short talk: Tobias Schmelzle (Harvard)
"Regulation of mammary epithelial morphogenesis and anoikis" |
| 11:20 am - 11:50 am | Wei Gu (Institute for Cancer Genetics, Columbia University)
"Dissecting the mechanism of p53 activation" |
| 11.50 am - 12.00 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session II |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Epigenetic Control and Genomic Instability |
| Discussion leader: Ashok Ventikaraman (Hutchison/MRc Research Centre) |
| 7:30 pm - 8:00 pm | Ashok Ventikaraman (Hutchison/MRc Research Centre)
"Linking epigenetic control mechanisms to the DNA damage response" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Yang Shi (Harvard)
"Regulation of histone methylation by demethylases" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Maarten van Lohuizen (Netherlands Cancer Institute)
"Role of Polycomb group repressors in stem cells, cancer & development" |
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Functional genetic approaches to cancer |
| Discussion leader: Reuven Agami (Netherlands Cancer Institute) |
| 9:00 am - 9:30 am | Reuven Agami (Netherlands Cancer Institute)
"Functional genetic approaches to identify cancerous microRNAs" |
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:10 am | Steve Elledge (Harvard)
"Genetic screens reveal novel steps in the spindle checkpoint pathway" |
| 10:10 am - 10:20 am | Discussion |
| 10:20 am - 10:50 am | Coffee Break |
| 10:50 am - 11:20 am | Julian Downward (London Research Institute)
"High (and low) throughput approaches to analyzing Ras oncogenic signaling" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:45 am | Short talk: So Young Kim (Harvard)
"Screening a genome-scale RNAi library to identify genes essential for cancer cell survival" |
| 11:45 am - 12:00 pm | Short talk: Maria L Nieto (Harvard)
"Dissecting Androgen Receptor Signaling with Functional Genomics" |
| 12:00 pm - 12:15 pm | Short talk: Alejandro Sweet-Cordero (Stanford)
"Functional genomics of oncogenic Kras signaling" |
| 12:15 pm - 12:30 pm | Short talk: Jen-Tsan Ashley Chi (Duke)
"Gene expression programs in response to hypoxia; cell type specificity and prognostic significance in human cancers" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session III |
| 6:00 pm | Lobster Dinner |
| 7:30 pm - 9:30 pm | Predictive and prognostic biomarkers of cancer |
| Discussion leader: Laura Van't Veer (Netherlands Cancer Institute) |
| 7:30 pm - 8:00 pm | Laura Van't Veer (Netherlands Cancer Institute)
"Genomic hard-wiring foretells tumor fate" |
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:40 pm | Sebastian Nijman (The Broad Institute)
"Genetic Screens in the TGF-beta pathway" |
| 8:40 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:20 pm | Xiao-Fan Wang (Duke)
"Extracellular proteins and tumor metastasis" |
| 9:20 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
