Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: CAZymes for Environmental Sustainability and Human Health
7:40 pm - 7:55 pm
Introduction by Discussion Leader
7:55 pm - 8:25 pm
"Development of Modular Platforms for Cell Free Biosynthesis of Complex Polysaccharides"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:05 pm
"Gut Microbial Glycoside Hydrolases"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Mechanisms of Complex Carbohydrate Degradation
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Recent Insights into LPMO Structure, Function and Operational Stability"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"The Sabatier principle as a tool for the discovery and engineering of Carbohydrate-active enzymes"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Discovering Arabinofuranosidases for Deconstruction of Mycobacterial D-Arabinan"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
"Measurement and Visualization of LPMO Activity on Natural Substrates"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:15 pm
"Functional Analysis and Physiological Roles of a Novel Crystalline Cellulose Binding Domain"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Visualizing CAZyme-Substrate Interactions
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Mr. Cell, Tear Down This Wall: Visualizing Cellulose Biosynthesis, Assembly, & Degradation"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Pausing, Processivity, and Product Inhibition: Single-Molecule Imaging of Cel7A on Cellulose"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Super Resolution Investigation of Productive Binding Sites on Cellulose Towards Improving Bioconversion"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"You are what you eat: Visualizing and quantifying microbial glycan metabolism in situ"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Bacterial CAZymes Targeting Human Host Glycans
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Processing of Glycoproteins by Host-Adapted Bacteria"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Turning universal O into rare Bombay type blood"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Structural and Mechanistic Insights Into Sulfatases"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"SpikeHunter: A Deep-Learning Classifier for Identifying Phage Tailspike Proteins"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Integrated Spatial Metabolome, Lipidome, and Glycome Analysis from a Single Tissue Section"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CAZymes Prospecting and Discovery
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"From dbCAN to dpCAN: Application of Machine Learning for new CAZyme Discovery"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Characterizing the microbial communities and enzymes responsible for carbohydrate metabolism in the rumen"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Family 92 Carbohydrate-Binding Modules: Structure, Function, and Impacts on Enzyme Activity."
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Plant Cell Wall Construction and Deconstruction
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"Navigating Molecular and Structural Complexity in Cell Wall Modification and Degradation"
9:35 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Co-Evolution of Hemicellulases from a Xylan PUL to Identify Molecular Determinants of Enzyme Synergy"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Conserved Active Site Architecture between Bacterial Cellulose and Chitin Synthases"
10:10 am - 10:15 am
Discussion
10:15 am - 10:45 am
Coffee Break
10:45 am - 10:55 am
"The Next Dimension of CAZymes - Inferring the Interplay Between Groups of Different CAZy Families"
10:55 am - 11:00 am
Discussion
11:00 am - 11:10 am
"Effect of Lignin-Related Compounds on Cellulases: True Inhibitors or not?"
11:10 am - 11:15 am
Discussion
11:15 am - 11:40 am
"Microbial Decomposition of Spruce Bark"
11:40 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Atomistic Modeling of Plant Cell Walls"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CAZymes for Novel Glycan Synthesis
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Applications of Carbohydrate-Active Enzymes in Bio-conjugate Synthesis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
"Simulation of Glycosyltransferase Catalytic Mechanisms"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Computational Insights into the Substrate Specificity of Xanthan Glycosyltransferases"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
CAZyme-Based Biotherapeutic Design
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:35 am
"The Different Paths to Resistant Starch Degradation and Their Impact on Human Health"
9:35 am - 9:45 am
Discussion
9:45 am - 10:10 am
"Development of a Polysaccharide Sensing and Degradation Signature (PSDS) in the Bacteroidota to Manipulate Human Health and Nutrition"
10:10 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
"Development of Glycogen Active Enzymes as Therapeutics in the Central Nervous System"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"The Influence of the Glucoamylase Inhibitor Acarbose on the Bacteroidetes Starch Utilization System"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
"Environmental Screening for Enzymes that Act Upon Sulfate and Zwitterion-Modified Sugars"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
CAZyme-Assisted Biomaterial Production
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:05 pm
"Sequence, Structure and Specificity in Hydrophobin Interactions During Liganocellulosic Biomass Deconstruction"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Ancestral Sequence Resurrection for the Design and Characterization of Novel Expansin-related Proteins"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
"LPMOs Alone and in Biocatalytic Cascade for Cellulose Fiber Surface Functionalization"
8:55 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure