Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Unraveling Arrhythmia Mechanisms: Ion Channel Function and Regulation
3:15 pm - 3:25 pm
"Molecular Mechanisms of Cardiotoxicity Linked to Tyrosine Kinase Inhibition"
3:25 pm - 3:30 pm
Discussion
3:30 pm - 3:40 pm
"Zebrafish-Specific Computational Atria and Ventricle Action Potential Models"
3:40 pm - 3:45 pm
Discussion
3:45 pm - 3:55 pm
"Profiling Cellular Ion Channel Variability: Unveiling Repolarization Heterogeneity in the Infarct Border Zone"
3:55 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Multi-Scale Approaches to Understanding Arrhythmias at the Myocyte, Tissue, and Organ Level
5:30 pm - 5:40 pm
"Towards Precision Medicine in Tetralogy of Fallot: Biophysical and ML-Based Arrhythmia Predictions"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
"Wnt5a Promotes Ventricular Arrhythmia by Inducing Calcium Alternans"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
"Regional and Sex-Specific cAMP Dynamics in the Intact Atria"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
"Effect of Optogenetic Defibrillation on Cardiomyocytes Under Healthy and Ischaemic Conditions"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Unraveling a Nav1.5 Selectivity Filter Mutations: Implications for Channel Function and Arrhythmia Pathogenesis"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:15 pm
"Making an Impact as a Scientist Without Compromising Your Ethics, Principles, or Well-Being"
7:15 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Basic Science Meets Translational Research Through Mapping, Modelling, and Precision Medicine
9:00 am - 9:10 am
"Metformin Protects Against Atrial Fibrillation in Racehorses"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Computational Modeling Reveals Sex-Specific Mechanisms and Therapeutic Targets for Atrial Fibrillation"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Genetic Variants in Myoferlin (MYOF) Control Calcium Handling and Underlie Arrhythmogenic Cardiomyopathies"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Adverse Cardiac Remodeling in Type 2 Diabetes: A Multi-Scale Approach from Clinical Biomarkers to Arrhythmia Mechanisms"
9:55 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Multi-Scale Career Advice and Lessons Learned
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Advancing Current Techniques and Strategies in the Study of Cardiac Arrhythmias
1:30 pm - 1:40 pm
"Using Quadruple Parametric Optical Mapping to Study MECC in the Heart"
1:40 pm - 1:45 pm
Discussion
1:45 pm - 1:55 pm
"Impaired Cardiac Mechanics in 3D Cardioids Derived from Arrhythmogenic Cardiomyopathy Patient iPSCs"
1:55 pm - 2:00 pm
Discussion
2:00 pm - 2:10 pm
"Comparing Diastolic Performance and Dysfunction by Sex in a Rat Model of HFpEF"
2:10 pm - 2:15 pm
Discussion
2:15 pm - 2:25 pm
"Cardiac Fibrosis Affects Electrical Conduction and Arrhythmogenesis in a Pacing-Rate-Dependent Manner"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes