Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Cardiac Repair and Regeneration
Discussion Leader: Thomas Eschenhagen (University Medical Center Hamburg Eppendorf, Germany)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
Guo Huang (University of California, San Francisco, United States)
"An Evo-Devo Lens into Why Our Heart Can’t Regenerate"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Chulan Kwon (Johns Hopkins University, United States)
"Cardiac Progenitor Development in Organoid Model"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:05 pm
Jennifer Davis (University of Washington, United States)
"Unlocking the Secrets of Fibroblast Biology: Their Role in Cardiac Tissue Homeostasis"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Myofilament and Cytoskeleton
Discussion Leaders: Leslie Leinwand (University of Colorado Boulder, United States) and Wolfgang Linke (University of Münster, Germany)
9:00 am - 9:20 am
Jil Tardiff (University of Arizona, United States)
"Modulating Cardiac Thin Filament Function: Leveraging Atomistic Structure to Develop New Therapeutic Options in Sarcomeric Cardiomyopathies"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Jolanda van der Velden (Amsterdam UMC, The Netherlands)
"Phosphoproteomics Screen Identifies Kinases Involved in Microtule Remodeling in Hypertrophic Cardiomyopathy"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
John Hinson (The Jackson Laboratory for Genomic Medicine, United States)
"Studying TTN Variants In Vivo Using CRISPR"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Stefan Raunser (Max Planck Institute of Molecular Physiology, Germany)
"In Situ Structures of Muscle Sarcomere and Sarcomeric Proteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany) and Leslie Kennedy (East Carolina University, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Excitation-Contraction Coupling and Arrhythmias
Discussion Leader: Bjorn Knollmann (Vanderbilt University School of Medicine, United States)
7:30 pm - 7:50 pm
Rengasayee Veeraraghavan (The Ohio State University, United States)
"Ion Channel-Rich Nanodomains and Their Dynamic Influence on Cardiac Rhythm"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Stéphane Vassilopoulos (Sorbonne University, France)
"Caveolae and Bin1 Rings: Correlative Microscopy Reveals the Origin of T-Tubules"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Donald Bers (University of California, Davis, United States)
"Ca-CaMKII Signaling in Heart Failure and Arrhythmias"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ana Gomez (INSERM, France)
"RyR2 Involvement in Rhythm and Arrhythmias"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cardiac Remodeling
Discussion Leader: Farah Sheikh (University of California San Diego, United States)
9:00 am - 9:25 am
Edward Thorp (Northwestern University, United States)
"Dichotomies of Phagocyte Function in Heart"
9:25 am - 9:30 am
Discussion
9:30 am - 9:55 am
Sarah Franklin (University of Utah School of Medicine, United States)
"Transcriptional Regulation by Lysine Methyltransferases"
9:55 am - 10:00 am
Discussion
10:00 am - 10:25 am
Judith Montag (Medical School Berlin, Germany)
"Nonsense-Mediated Decay of cMyBPC in Hypertrophic Cardiomyopathy Patients by UPF3B"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:25 am
David Kass (Johns Hopkins University School of Medicine, United States)
"Recipe for Making a HFpEF Heart"
11:25 am - 11:30 am
Discussion
11:30 am - 11:55 am
Sharlene Day (University of Pennsylvania, United States)
"Targeting Cardiac Metabolism in Hypertrophic Cardiomyopathy"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Technologies
Discussion Leader: Hongtu Zhu (University of North Carolina at Chapel Hill, United States)
7:30 pm - 7:55 pm
Natalia Trayanova (Johns Hopkins University, United States)
"AI-Powered Personalized Computational Cardiology"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:25 pm
Patrick Ellinor (Massachusetts General Hospital & The Broad Institute of MIT and Harvard, United States)
"CARDIO: Unveiling New Heart Failure Genes through High-Content Imaging"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:55 pm
Jennifer Van Eyk (Cedars-Sinai Medical Center, United States)
"Is Drug Response Hetergeneity Driven by Individual Cardiomyocyte Proteome Hetergenity?"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mitochondria and Metabolism
Discussion Leader: Gabriele Schiattarella (Charité University Medical Center / Max Delbrück Center for Molecular Medicine, Berlin, Germany, Germany)
9:00 am - 9:20 am
Christoph Maack (University Clinic Würzburg, Germany)
"Mitochondrial Redox Regulation in Heart Failure"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Asa Gustafsson (University of California San Diego, United States)
"Novel Mechanisms of Mitochondrial Quality Control in the Heart"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Elizabeth Murphy (National Institutes of Health, United States)
"Role of Mitochondrial Ca2+ Efflux in the Rise in Mitochondrial Ca2+ During Ischemia"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Ryan Boudreau (University of Iowa, United States)
"Mitochondrial Microproteins"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Inter-Organ Communication
Discussion Leader: Maria Kontaridis (Masonic Medical Research Institute, United States)
7:30 pm - 7:50 pm
Julie McMullen (Baker Heart and Diabetes Institute, Australia)
"Inter-Organ Cross-Talk in Settings of Physiological and Pathological Cardiac Hypertrophy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jose Angel Nicolas Avila (University of California San Francisco (UCSF) , United States)
"A Role for Macrophages in Tissue Homeostasis Via Heterophagy and Metabolic Adaptation"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Hongtu Zhu (University of North Carolina at Chapel Hill, United States)
"Heart-Brain Connections: Phenotypic and Genetic Insights from Magnetic Resonance Images"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Short Talk Selected from Poster Abstracts
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Short Talk Selected from Poster Abstracts
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Novel Therapies
Discussion Leader: Yibin Wang (Duke-NUS Medical School, Singapore)
9:00 am - 9:20 am
Wolfram Zimmerman (University Medical Center Göttingen, Germany)
"Tissue Engineered Heart Repair in Patients with HFrEF: Lessons Learned"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Michael Regnier (University of Washington, United States)
"Targeting Cardiac Thick Filament Activation for Hypo-contractile Hearts"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Glynnis Garry (UT Southwestern Medical Center, United States)
"Rewiring Fate: Defining Epigenetic Drivers of Cardiac Reprogramming"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Long-Sheng Song (University of Iowa, United States)
"Targeting Junctophilin-2 for Heart Failure Gene Therapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Short Talk Selected from Poster Abstracts
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Short Talk Selected from Poster Abstracts
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Short Talk Selected from Poster Abstracts
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Short Talk Selected from Poster Abstracts
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Cardiovascular Disease and Therapeutics
Discussion Leaders: Lucie Carrier (University Medical Center Hamburg-Eppendorf, Germany) and Timothy McKinsey (University of Colorado Anschutz Medical Campus, United States)
7:30 pm - 8:10 pm
E. Dale Abel (UCLA David Geffen School of Medicine, United States)
"Insulin Signaling in the Cardiovascular System"
8:10 pm - 8:30 pm
Discussion
8:30 pm - 9:10 pm
Thomas Thum (Medizinische Hochschule Hannover, Germany)
"The Advent of RNA Therapeutics: From Cell Culture Dishes to a Phase 2 Clinical Study in Heart Failure Patients"
9:10 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure