Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Skeletal and Joint Development
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:05 pm
"Novel Insights into the Mechanisms of Synovial Joint Cavitation during Mouse Embryo Limb Skeletogenesis"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
"Wnt5a Signaling in Limb Development and Autosomal Dominant Robinow Syndrome"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Fgfr3 Enhancer Deletion Markedly Improves all Skeletal Features in a Mouse Model of Achondroplasia"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Unraveling Cartilage Morphogenesis: Towards Computational Reconstruction of Growth Plate Temporal Dynamics at Cellular Resolution"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Creb5 Controls its Own Expression, Directly Induces the Synovial Joint-Interzone Regulatory Program, and Coordinates the Patterning of the Intervertebral Disc"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Evolution and Regeneration of the Limb
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Oxygen-Sensitivity and Evolution of Limb Regeneration"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Lizard Tails as Instructive Models of Blastema-Based Cartilage Regeneration"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"How Function in Skeletal Stem Cells is Critical for Signaling Required during Fracture Repair"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Bipedalism in Two Steps: Dual Innovations Underlie the Hominin Pelvis"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:25 am
"Salamander Limb Regeneration - Regulation and Evolution"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"An iPSC-Based Model of in Vitro Cartilage Mineralization: Insights into MAFB’s Role in Multicentric Carpotarsal Osteolysis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Genetic Interactions between Sox9 and Adgrg6 Contribute to Altered Fibrocartilage and Increased Susceptibility to Severe Scoliosis in Mice"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:20 pm
"Dynamics of Cellular Heterogeneity of the Human and Mouse Notochordal Cell Lineage. Implications for Intervertebral Disc Development and Degeneration"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signalling Inside and Outside the Cell
7:30 pm - 7:50 pm
"Intrinsic Articular Cartilage Repair is Driven by Matrix Bound Growth Factors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Ciliary Variants Reveal Requirements for Chondrogenic and Osteogenic Differentiation of Cranial Neural Crest Cells"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Inhibition of Lsd-1 Maintains Articular Cartilage Integrity in a Murine Post-Traumatic OA Model"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"A Cartilage-Enriched G Protein-Coupled Receptor Maintains Articular Cartilage Homeostasis via Promoting Gs Signaling in Mice"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Integrin Alpha10 is Involved in the Response of Chondrocytes to Dynamic Compression"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Targeting SHP2 using SHP2D26 PROTAC Degrader to Promote Articular Cartilage Anabolism and Homeostasis"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Genomics and Epigenomics: Nature and Nurture
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Epigenomics in Cartilage Development and Disease: MicroRNAs and More"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Epigenetic Regulation of Aging and Osteoarthritis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Defining the Developmental Mechanisms in Cartilage That Underly Adolescent Idiopathic Scoliosis in Females"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Leveraging Epigenomic Datasets to Elucidate Genetic Risk of Musculoskeletal Disease"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"From Osteoarthritis Genetics to the Clinic: Identifying Biological Pathways and Drug Repurposing Possibilities"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"From Genomics and Epigenomics to Disease Phenotyping OA"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Using hPSC-Derived Models and CRISPR Cas 9 Gene Editing To Explore TLR4’s Contribution to Cartilage Inflammation and Degradation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Examining the Role of the Splicing Factor SRSF3 in Cartilage Differentiation and Osteoarthritis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Extracellular Matrix in Health and Disease
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"The Cartilage Micromechanical Environment: Linking Extracellular Matrix to Tissue Function"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Role and Mechanisms of Cartilage Calcification in OA"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Spatial and Diurnal Variations in Sodium Content within Intervertebral Disc Tissue"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Agrin Is a Key Protective Component of the Inflammatory-Response in Early OA"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Osteogenesis Imperfecta-Causing Mutations in KDELR2 Lead to Impaired Collagen Secretion and Quality in the Skeletal System and Affect Survival of Mice and Zebrafish"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Mechanobiology and Biomechanics
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Modeling Biomechanics in the Zebrafish Jaw Throughout the Life Span: Influences of Aging and Genetic Mutations"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Predicting Cartilage Adaptation in KOA Patients: Where in Vitro Research Meets Multi-Scale Modeling"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Athletic Giftedness and Genetics"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:10 am
Late-Breaking Topic
11:10 am - 11:20 am
Discussion
11:20 am - 11:30 am
"Multiscale Mechanobiology of Articular Cartilage: Insights From In Silico and In Vitro Approaches"
11:30 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and HTRA1 Overproduction in Osteoarthritis"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Regulation of Postnatal Skeletal Development by Mechanosensitive Osteolectin+ Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"The Function of Plastin-3, an Actin-Binding and -Bundling Protein, in Cartilage Homeostasis"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tissue Engineering and Stem Cell Biology
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"A Platform to Evaluate Fetal Chondrocyte Gene Regulatory Networks in Human Chondrocytes"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Mechanoregulation of Joint Tissues in Development and Disease"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Sca!old Microarchitecture Drives Vascularization of a Cartilaginous Template for Bone Formation"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Non-Viral Gene Delivery using Engineered Extracellular Vesicles to Reprogram Human Annulus Fibrosus Cells on 3D-Matrices Mimicking Health and Disease"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Neural Crest-Derived Chondrocytes as a Promising Cell Source for Cartilage Regeneration"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Cartilage Disease: Pathogenesis and Drug Discovery
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
"Matrix Protein Anabolic Indices Identify Regenerative Cartilage Small RNAs"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
"Advancing Osteoarthritis Therapeutics by Defining Cartilage Progenitors and their Regulatory Niche"
9:55 am - 10:05 am
Discussion
10:05 am - 10:15 am
"A WNK2 Mutation Associated With Familial Osteoarthritis Induces Bone Remodeling in Response to Injury"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Old Knees, New Insights. Exploring the Relationship between Osteoarthritis, Aging, and Fat"
10:30 am - 10:35 am
Discussion
10:35 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Electromechanical Grading of Human Tibia Plateau Cartilage to Associate Transcriptome Patterns with OA-Pathology"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Drug Repurposing in Rare Bone Diseases"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Development and Screening of Extracellular Matrix Reporter Cells for Cartilage Regeneration in Osteoarthritis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Imaging Mass Cytometry Reveals Distinct Synovial Cell Immunophenotypes in Overloading and Surgical OA Models"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Emerging Technologies and Models
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
"Mass-Production of Advanced Micromaterials for Scalable Production of Modular Living Tissues"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
"Multiphoton Microfabrication and Micropatterning (MMM) Platform Technology for Cell Niche Engineering"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Unravel the Phenotype of Chondrocytes in the Zone of Calcified Cartilage and their Response to Osteoarthritic Factors"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"A Novel Injectable Regenerative OA Therapy"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:20 pm
"Village-in-a-Dish: Population Genetic in a Dish To Investigate Osteoarthritis Heterogeneity"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure