Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Modeling Cartilage Disease: Development, Progression, and Degeneration
3:45 pm - 3:50 pm
Introduction by Discussion Leader
3:50 pm - 4:05 pm
"Modelling Cartilage: The Complex Challenges of a Simple Tissue"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Osteochondral Disease and Regeneration: From Virtual Patients to Living Implants"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Innovative Models of Cartilage Development and Regeneration: Connecting Biology and Bioengineering
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:45 pm
"Biofabrication of a Stable Hyaline Cartilage Graft from Genetically Engineered MSCs with Enhanced Chondrogenic Potential"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
"Self-Assembling Cell-Like Micromaterials with Induced Pluripotent Stem Cell Creates Engineered Living Materials with Dynamically Programmable Behaviour to Steer Chondrogenic Lineage Commitment"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
"The Gene and Immunohistochemical Profile of Mechanically Activated PIEZO and TRP Channels in Re-Differentiated Human Cartilage Endplate Cells"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
"Hox Function in Skeletal Stem Cells Is Critical for Signaling Required During Fracture Repair"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
"Master Roles for RUNX2/RUNX3 in Growth Plate Chondrocytes"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:00 pm
"Investigating the Molecular Mechanisms of Marker Expression During Fibrous Differentiation in the Spine"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:15 pm
"Characterizing the Role of Mab21l2 Expression During Skeletal Joint Development"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Models to Study the Mechanisms of Cartilage Disease and Degeneration
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:15 am
"Old Knees, New Insights: Exploring the Relationship Between Osteoarthritis, Aging, and Fat"
9:15 am - 9:20 am
Discussion
9:20 am - 9:30 am
"Metabolic Stress Accelerates Dysregulated Synovial Macrophage-Fibroblast Communication and Htra1 Overproduction in Osteoarthritis"
9:30 am - 9:35 am
Discussion
9:35 am - 9:45 am
"Aging Promotes Aberrant IVD Neutrophil Recruitment and Exacerbates Degeneration Following Injury"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
"Mechanical Loading Causes an Osmolality-Dependent Response in Chondrocytes"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
"Impact of Environmental Conditions on Osteochondral-Synovium Co-Culture"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"Role of Wnt-Integrin Signaling in Impaired Chondrocyte Mechanotransduction in the Context of Early Osteoarthritis"
10:30 am - 10:35 am
Discussion
10:35 am - 10:45 am
"Transgenic Fibrillin-1 Loss From Whole Joints, but Not from Cartilage Only, Promotes Osteoarthritis Development in a Mouse Knee Overloading Model of Disease"
10:45 am - 10:50 am
Discussion
10:50 am - 11:00 am
General Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Navigating Careers in Musculoskeletal Biology
1:30 pm - 2:30 pm
Panel Discussion
Navigating Careers in Musculoskeletal Biology
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes