Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Megakaryocytes and Platelet: Nature and Nurture
7:40 pm - 8:00 pm
General Discussion
8:00 pm - 8:35 pm
"The Biblical Problem with Thrombopoiesis"
8:35 pm - 8:45 pm
Discussion
8:45 pm - 9:20 pm
"Shaping Platelets: How 3D Niche Models Unlock Megakaryocyte Mysteries Beyond 2D Cultures"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Deconstructing Megakaryocytes
9:00 am - 9:20 am
"Megakaryocyte Direct Differentiation from Hematopoietic Stem Cells"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"To Bleed or not to Bleed: A Stem Cell Question"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Alternative Platelet Differentiation Pathways Initiated by Nonhierarchically Related Hematopoietic Stem Cells"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Group Photo / Coffee Break
11:00 am - 11:20 am
"The Secret(e) and Not-So-Secret Lives of Megakaryocytes"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Extramedullary Megakaryocytes: Insights from Cleared Tissue Imaging and Spatial Transcriptomics"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address the interests and needs of all scientists and the challenges they face in their careers. Specifically, the program promotes meaningful conversations amongst colleagues of all career stages about barriers to career advancement and strategies to support the professional growth of all members of the community. The GRC Power Hourâ„¢ is open to all conference participants.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:50 pm
"Back to The Future or License to Chill? Platelet Transfusions in 2025"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Genetic Engineering of Transfusable Donor Platelets with mRNA-Lipid Nanoparticles"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Ex Vivo Genetic and Pharmacological Targeting of RHOA in Platelet Therapy"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Effects of Platelet Transfusion on Neonatal Bleeding and Inflammation"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Next Generation Synthetic Platelet Technologies for Hemostatic Therapy"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Platelet Production and Function
9:00 am - 9:20 am
"Megakaryo-Sites: Engineered Bone Marrow Niches and their Effects on MK Biology"
9:20 am - 9:30 am
Discussion
9:30 am - 9:40 am
"CXCL12 Abundant Reticular (CAR) Cells Spatially Regulate Platelet Production in the Bone Marrow"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"In Vivo Visualization of Megakaryopoiesis Within the Intact Bone Marrow"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Megakaryocyte-Neutrophil Emperipolesis Yields Procoagulant Platelets"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Aging Platelets Shift Their Hemostatic Properties to Inflammatory Functions"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"GPIbα Signaling and Crosstalk"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Personalized 3D Vessel-on-Chip: Towards 'Sherlock Holmes' Approach to Detecting Blood Clots"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Rogue Megakaryocytes and Platelets
7:30 pm - 7:50 pm
"Traveling to Enchanted Lands to Find Genes for Platelet Traits"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Hiding in Plain Site: When Thrombocytopenia is More Than a Megakaryocyte Thing"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Platelet Reactivity Expression Score (PRESS): Time to Revisit our Approach to Antiplatelet Therapy using Precision Based Care"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Tet2 Age-Associated Somatic Mutations Impair Megakaryopoiesis and Platelet Function in Clonal Hematopoiesis"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Platelets Sequester Extracellular DNA, Captured Tumour-Derived and Free Fetal DNA"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflamed Megakaryocytes, Platelets and Vessels
9:00 am - 9:20 am
"Platelet Factors Attenuate Inflammation and Rescue Cognition in Aging"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"The Journey of Megakaryocytes Through the Immune Fields"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Loss of Layilin Augments Platelet Activation via RAC1 in Inflammatory Bowel Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Identification of Distinct Hemostatic Mechanisms Linked to Endothelial Necroptosis and Apoptosis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Platelet-Neutrophil Interactions: Kiss of Death or Lifesaver?"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Intersections, Not Tangents: The Crosstalk Between Neutrophil Proinflammatory Responses and Platelets"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Platelets in the Immune Crossfire
7:30 pm - 7:50 pm
"FcRn: Can’t Leave Home Without it"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Untangling the NET: How Platelet Collaborate with Neutrophil Extracellular Traps to Promote Immune Homeostasis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Highway to the Danger Zone: Locking on PF4 to Take Down HIT"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Complement Activation in HIT"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Megakaryocyte and Platelet Regulators
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Granule Cargo Packaging and Release from Platelets and Megakaryocytes: Roles and Perspectives"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"When Platelet Mitochondria Never Ever Get Back Together"
10:00 am - 10:10 am
Discussion
10:10 am - 10:30 am
General Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Thrombo-Olfaction: New Targets for Antiplatelet Therapy"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Targeted Platelet Therapy: Unlocking the Power of PROTACs"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Phosphodiesterase 5 (PDE5) Hydrolyzes Elevated cAMP Levels in Megakaryocytes and Platelets"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Yap/Taz Regulated Megakaryocyte Cytoskeleton to Control Platelet Formation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Platelet Therapeutics
7:30 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:20 pm
"From Crystal to Clinical Trial: The Zalunfiban (RUC-4) Story"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 9:05 pm
"Platelet Immune Receptors: Completing the Jigsaw"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure