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Cell Biology of Megakaryocytes and Platelets (GRS)

Gordon Research Seminar

The Changing Landscape of Megakaryocyte and Platelet Biology

March 1 - 2, 2025

Chairs

and

Ventura Beach Marriott

2055 Harbor Boulevard

Ventura, California, United States

Venue and Travel Information

Conference Description

The Cell Biology of Megakaryocytes and Platelets GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

In the last couple of decades there have been an increasing number of diverse biological functions attributed to megakaryocytes and platelets, with challenges to the dogmas in the field. At this GRS we will highlight and discuss the research of trainees into these fascinating cells and their progeny. We hope to provide an inclusive and engaging schedule that will enable the next generation of megakaryocyte and platelet researchers to troubleshoot and tackle the biggest unsolved mysteries in our field with like-minded peers.

Related Meeting

This GRS will be held in conjunction with the "Cell Biology of Megakaryocytes and Platelets" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Anatomy of Hematopoiesis Discussion Leader:
3:45 pm - 4:15 pm	"The Anatomy of Hematopoiesis"
4:15 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Canonical Roles of Megakaryocytes and Platelets Discussion Leaders: and
7:30 pm - 7:40 pm	"CXCL12 abundant reticular (CAR) cells spatially regulate platelet production in the bone marrow"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	""GBM Platelet Hyperactivity Drives the Immunosuppressive TME in a Sex-Dependent Manner""
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Impact of PACSIN2 on Megakaryocyte and Erythrocyte Development"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Investigating the Kinetics and Dynamics of Movement of GPVI and CLEC-2 upon Ligand Engagement"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Yap/Taz regulate megakaryocyte cytoskeleton to control platelet formation"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"PF4 Potentiates FcγRIIA Stimuli Independently of c-Mpl"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Platelet-derived serotonin drives lung immunopathology in aged SARS-CoV-2 infected mice"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"VAMP8 Deficiency Attenuates AngII-Induced Abdominal Aortic Aneurysm Formation via Platelet Reprogramming and Enhanced ECM Stability"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Non-Canonical Functions of Megakaryocytes and Platelets Discussion Leaders: and
9:00 am - 9:10 am	"Lung Megakaryocyte Proliferation is Specifically Reduced During Early-Stage Lipopolysaccharide Induced Acute Lung Injury"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Platelet Endocytosis and α-Granule Cargo Packaging are Essential for Normal Skin Wound Healing"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Platelets Mediate Transfer of Exogenous mRNA to Other Cells and Tissues: Leveraging a Natural Mechanism for RNA Delivery"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Platelets Hijack Neutrophils for Pro-Tumour Polarisation in Liver Cancer"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"Excess Gelectin1 in Myeloproliferative Neoplasms Induces Platelet Activation and Pro-Fibrotic Megakaryocytes"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"The Spleen Modulates Systemic Platelet Activation"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Influenza A Virus Infection Accelerates the Onset of a Unique HSC-direct and Age-progressive Platelet Pathway"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Myb Regulation of Megakaryocyte Immune Differentiation"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Careers in Science Beyond the Bench Panel Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Careers Beyond the Bench
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under Award Number 1R13HL178271-01. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Cell Biology of Megakaryocytes and Platelets

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