Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
7:40 pm - 7:45 pm
Opening Remarks
7:45 pm - 8:10 pm
"Meeting Your Quota: The Cellular Economy of Zinc"
8:10 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
"Mining Metalloproteome by Chemical and Computational Proteomics"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
"Structural and Functional Characterization of Processes for Copper Transport and FeS Protein Biogenesis"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Metals at the Host-Pathogen Interface
9:00 am - 9:25 am
"In Vitro Reconstitution and Mechanistic Dissection of Iron Transport at the Host-Pathogen Interface for Legionella pneumophila "
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Vitamin B12 and Other Metal-Based Mechanisms in Bacterial Light Sensing and Signaling"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Feeding on the Host: How Do Human Fungal Pathogens Acquire Essential Trace Metals During Infection?"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Iron Utilization by Malaria Parasites"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Bacterial Adaptation to Manganese Starvation: A Tale of Two Enzymes"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Transcriptional and Translational Reprogramming in Response to Copper Status in the Pathogenic Fungus Cryptococcus neoformans "
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Sensation and Homeostasis
6:00 pm - 6:25 pm
"Molecular Mechanisms of Bacterial Metallostasis"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Regulatory and Metabolic Responses to Iron Deficiency"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Zinc Sensing and Signaling in C. elegans "
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Selective Recognition and Utilization of Lanthanides in Biology"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"A Novel Liver/Gut/Microbiota Axis Control Iron Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Serum and Tissue Iron Sensing by the Liver"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"An Unexpected Role for Metal Transporters in Systemic Metabolism"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Out-of-Balance: Pathophysiological Consequences of Iron Overload"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Hepatic Bioenergetic Deficiency Induces a Novel Signal that Systemically Suppresses the Immune System"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Role of Zinc at Neuronal Nerve Terminals"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Bile Acid Regulation of Intestinal Manganese Transport"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cellular Metal Partitioning
6:00 pm - 6:25 pm
"Ironing-out the Connection Between Mitochondria and Lysosomes"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Mitochondrial Copper Transporter Modulates Targets Inside and Outside of Mitochondria"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Handling Heme: Probing the Mechanisms Underlying Heme Trafficking and Utilization"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Grab Regulates Endosomal Trafficking of The Transferrin Receptor in Developing Erythroblasts"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:25 am
"Molybdenum Cofactor Synthesis and Enzymes in Mitochondria"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Enzymology of Heme Biosynthesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"The Special Relationship Between Cobalt and the Corrin Ring of Vitamin B12"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Unraveling the Complex(ity) of Heme Synthesis and Distribution"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Understanding Cobalt Acquisition for Vitamin B12"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Structural Basis of Zinc-Dependent Protein Quality Control in the Early Secretory Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Control of Heme Biosynthesis and Acquisition in Staphylococcus aureus "
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
New Paradigms in Metal Metabolism
6:00 pm - 6:25 pm
"How Cells Import Copper and Cope with Copper Deficiency"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 7:00 pm
"Understanding Bacterial Metal Defense via Single-Molecule/Cell Microscopy"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:35 pm
"Zinc Regulation of the Mammalian Cell Cycle"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Uncovering Essential Metal Interactions in the Gut Microbiota: A Study on Lactobacillus plantarum and Zinc"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Metals in Physiology and Disease
9:00 am - 9:25 am
"Cardiovascular Iron Homeostasis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Manganese Homeostasis and Induced-Parkinsonism: Insights from Studies of a Rare Genetic Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:35 am
Coffee Break
10:35 am - 11:00 am
"Lessons from Porphyrias: Disproportion of Iron and Heme"
11:00 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Mechanisms of ATP7A-Related Copper Transport Diseases"
11:35 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Post-Transcriptional Regulation of Atp7a mRNA in Skeletal Muscle Myoblasts"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"New Roles of Transcription Factor Spic in Inflammation and Iron Metabolism"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cadmium Accumulation in Insulin Producing Beta Cells in the Pathophysiology of Type 2 Diabetes"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Cellular Metal Compartmentalization and Regulation
6:00 pm - 6:05 pm
Introduction by Discussion Leader
6:05 pm - 6:45 pm
"Metal Dynamics: From the Soil to the Seed"
6:45 pm - 7:00 pm
Discussion
7:00 pm - 7:05 pm
Introduction by Discussion Leader
7:05 pm - 7:45 pm
"Biogenesis of Iron-Sulfur Proteins in Eukaryotes: Mitochondria, Mitosomes, Mechanisms and Maladies"
7:45 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure