Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Molecular Basis of Intercellular Adhesion
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:40 pm
"Cell-Cell Adhesion Studies: History and Perspective"
8:40 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Regulation of Cell-Cell Junctions
9:00 am - 9:25 am
"Mechanisms of Signalling at Apical Epithelial Junctions"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Surprising Functions of Desmosomal Cadherins in Development and Disease"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Reciprocal Regulation of AJ and TJ During the Assembly of Apical Adhesion Complex"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Cytoskeletal Integration of Biochemical and Adhesive Cues"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Coupling Mechanotransduction and Cell Metabolism"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Using Optogenetic Tools to Determine How Local Tight Junction Leaks and the Rho Flare Repair Mechanism Are Triggered"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Mechanotransduction Through Adhesion Receptors
6:00 pm - 6:25 pm
"Force-Dependent Allosteric Regulation of Alpha-Catenin Binding to F-Actin by Vinculin"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"The Desmosome Is Mechanically Loaded in Response to Externally Applied Stress"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Modeling the Collective Behavior of Confluent Adhesive Cells"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Dynamic Actomyosin Pulses Induce Tension Imbalance to Drive Epithelial Cell Extrusion"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cell-Cell Adhesion as a Regulatory Mechanism During Development
9:00 am - 9:25 am
"Dynamics of Proliferative Epithelial Tissue"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Molecular and Mechanical Regulation of Tissue Morphogenesis"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Defining the Role of the Adherens Junction-Actin Cytoskeletal Linker Canoe/Afadin in Epithelia Integrity and Morphogenesis"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Control and Self-Organization in Tissue Morphogenesis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Multi-Level Regulation of the Crumbs Polarity Protein Controls the Dynamics of Epithelial Cell Ingression"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Mind the srGAP: Novel Roles for a Slit-Robo GAP During Epithelial Morphogenesis"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Quantitative Analysis of Adhesion Dynamics
6:00 pm - 6:25 pm
"Mind the Gap: Physical Segregation of Proteins at Cell-Cell Contacts"
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"Cell-Cell Adhesion Regulation in Mitosis and Ploidy"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Cadherins and Growth Factor Receptors in Force Transduction"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"Sensing of Forces by Asymmetric Endothelial Junctions for Angiogenesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Adhesive Regulation of Cell Behavior
9:00 am - 9:25 am
"Mechanobiology of Epithelial Growth and Folding"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Mechanisms of Nuclear Mechanoprotection and Mechanoadaptation"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"Emergence of Single Cell Mechanical Behavior and Polarity Within Epithelial Monolayers Drives Collective Cell Migration"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Epithelial Renewal in Gut Homeostasis"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Epithelial Function and Monolayer Integrity in Chronic Obstructive Pulmonary Disorder"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Nectin-Elicited Cytoplasm Transfer: A Process Accounting for Infection of Neurons by Measles Virus"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-Canonical Roles of Adhesion Receptors
6:00 pm - 6:25 pm
6:25 pm - 6:35 pm
Discussion
6:35 pm - 6:50 pm
"Structural Principles in Robo Activation and Auto-Inhibition"
6:50 pm - 6:55 pm
Discussion
6:55 pm - 7:20 pm
"Collective Cell Dynamics of Organ Renewal"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:45 pm
"An Adhesion Code Enables Robust Pattern Formation in the Zebrafish Spinal Cord"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:00 pm
General Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Adhesive Regulation of Cancer Cell Invasion and Metastasis
9:00 am - 9:25 am
"Loss of Epithelial Cell Adhesion and Breast Cancer Dormancy"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Multistep Fluidization of Multicellular Invasion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:25 am
"E-cadherin Is an Invasion Suppressor, Survival Factor, and Metastasis Promoter in Multiple Models of Breast Cancer"
10:25 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:25 am
"Neighbourhood Watch by Cell-Cell Mechanotransduction"
11:25 am - 11:35 am
Discussion
11:35 am - 12:00 pm
"Flow Signaling at Endothelial Cell-Cell Junctions"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
"Affinity of ZO-1 to Actin Modulates Barrier Function"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Keynote Session: Regulation of Morphogenesis by Adhesion
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 7:00 pm
"Planar Cell Polarity: From Cell Adhesion to Tissue Mechanics"
7:00 pm - 7:25 pm
Discussion
7:25 pm - 7:45 pm
General Discussion
7:45 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure