Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Perspectives on the Mechanism and Function of Cell Death in Physiology
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
"Cell Rupture in Dying Cells - How Does It Actually Happen?"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
"Assembly and Regulation Mechanisms of FADD:Caspase-8-Containing Signalling Complexes"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Inflammation and Tissue Homeostasis
9:00 am - 9:20 am
"Death in the Arvo - The Strange Tale of RIPK1 in AML"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"ZBP1 and Its Role in Cell Death and Inflammation"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Redefining Mitotic Catastrophe"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
"Neutrophil Funeral Planning or Life After Death?"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
"The Trojan Horse: T6SS Effectors Induce Pyroptosis within the Phagosome"
11:35 am - 11:40 am
Discussion
11:40 am - 11:55 am
"The STING/TBK1/IRF3/INF Type I Pathway is Defective in Cystic Fibrosis: A New Therapeutic Target for Bacterial Infections"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"There is a Crack: Plasma Membrane Integrity Sensing and Signaling"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Novel Switchable Mutant p53 Mouse Strains to Investigate p53 Gain-of-Function Effects in Tumours"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Group Photo / Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
6:00 pm - 6:20 pm
"Principles of Resolving and Non-Resolving Inflammation"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Dying in a World Full of Oxygen and Iron: Immunogenic Cell Death and Ferroptosis"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Vita-PAMPs in Noncanonical Inflammasome Activation and Pyroptosis"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Pyroptosis, a Lytic Cell Death Coordinating Host Defense and Inflammation"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Fundamental Mechanisms of Cell Death
9:00 am - 9:20 am
"A Vesicle Trafficking Cell Death Pathway Leads to Vacuole/Lysosome Membrane Permeabilization"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Illuminating Mitochondrial Permeabilization in Apoptosis"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Targeting c-FLIP in Extrinsic Apoptotic Network"
10:15 am - 10:20 am
Discussion
10:20 am - 10:30 am
"MLKL Polymorphs Among Us - Evolutionary Winners or Losers?"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:20 am
"TNFR2, Type I IFN and Cytokine Storms"
11:20 am - 11:25 am
Discussion
11:25 am - 11:40 am
"The Role of p63 in the Female Germline Fidelity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Mitochondrial E3 Ubiquitin Ligase MARCHF5 Controls BAK Function Independently of BH3-Only Proteins"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"Evolution in Mitochondrial Apoptotic Priming Drives Resistance to Leukemia Therapy"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Cell Death-Induced “Danger” Signals in Modulating the Local TME and Bone Marrow Microenvironment"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Cell Death in Neuroinflammation and Neurological disorders
6:00 pm - 6:20 pm
"dSarm/SARM1 Signaling in the Injured Nervous System"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Unexpected Function of the Inflammasomes in Axon Pruning"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:40 pm
"Targeting Disease Progression in the Nervous System at the Interface of Cell Death and Inflammation"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Cell Death by Phagocytosis Contributes to Neurodegeneration, Neuroinflammation and Brain Aging"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
9:00 am - 9:20 am
"What Doesn't Kill You, Makes You...Stressed: Exploring the Links Between Cell Stress, Cell Death and Inflammation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Regulation of Inflammatory Disease Signaling by RIP Kinases and IAP Proteins"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Connecting Autophagy and Inflammation to Regulate Programmed Cell Death"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:10 am
"Activation of the TRIFosome During the Innate Immune Response"
11:10 am - 11:15 am
Discussion
11:15 am - 11:30 am
"Mitochondrial Apoptosis Regulates Immune Responses Driven by Radiation Therapy"
11:30 am - 11:35 am
Discussion
11:35 am - 11:50 am
"The Role of Necroptotic Immune Responses in Liver Homeostasis and Hepatocarcinogenesis"
11:50 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Sensing DNA as a Danger Signal via the cGAS-STING Pathway"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"Reprogramming of Iron Metabolism Confers Ferroptosis Resistance in ECM-Detached Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Non-Apoptotic Forms of Cell Death
6:00 pm - 6:20 pm
"Ferroptosis Modulation for the Treatment of Complex Diseases"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Mitochondria as Inflammatory Signalling Platforms in Cell Death and Senescence"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Vulnerabilities and Function of Cell Death Pathways in Small Cell Lung Cancer"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Ferroptosis Targeting: Lifesaving at Intensive Care Units?"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Dual Roles of USP22 in Necroptosis and IFN-Mediated Cell Fate Signaling in Disease"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Harnessing Cell Death Mechanisms in Cancer
9:00 am - 9:20 am
"Necrosome Signaling and Immune Evasion in Lung Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Which Factors Decide Cell Death Versus Cell Cycle Arrest After p53 Activation?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Your Roots Matter: How Apoptosis Regulation in Cell of Origin Drives Broad-Scale Sensitivity or Resistance to Cancer Therapies"
10:15 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"A Genome-Wide CRISPR Screen Reveals Death and Survival Pathways that Determine the Response to Cisplatin in Bladder Cancer"
11:05 am - 11:10 am
Discussion
11:10 am - 11:25 am
"Focal Adhesion Kinase Plays a Dual Role in TRAIL Resistance and Metastatic Outgrowth of Malignant Melanoma"
11:25 am - 11:30 am
Discussion
11:30 am - 11:40 am
"A First-in-Class RIPK1 Degrader Sensitizes Immune Checkpoint Blockades by Overcoming Intrinsic Resistance in Cancer Cells and Activating B Cells for Antitumor Immunity"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
"Dissecting the Molecular Basis of Sterile Inflammation Upon Centrosome Aberrations"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
"RIPK1-independent Necroptosis Drives Anti-Tumor Immunity"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
"A Role for Fibroblast Derived SASP Factors in the Activation of Non-apoptotic Cell Death in Normal Mammary Epithelial Cells"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Infectious Diseases and Cell Death
6:00 pm - 6:20 pm
"Cell Death and Cell Architecture During Bacterial Infection"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
"Novel Fluorescent TNF Reporter Systems for Characterisation of TNF Expression"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 7:05 pm
"It’s Not You, It’s Me: ZBP1 as a Driver of Autoinflammation"
7:05 pm - 7:15 pm
Discussion
7:15 pm - 7:35 pm
"No Time to DAI: ZBP1-Triggered Cell Death in Influenza and Immunotherapy"
7:35 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
General Discussion
7:55 pm - 8:00 pm
Closing Remarks
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure