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Cell Growth and Proliferation

Gordon Research Conference

Cell Cycle and Cell Proliferation in Development and Disease

July 9 - 14, 2023

Chair

Vice Chair

Conference Description

The Cell Growth and Proliferation GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

This conference will focus on the fundamental mechanisms of normal and abnormal cell proliferation, how the cell cycle is regulated in various physiological and pathologic states, how that modulation affects development, tissue regeneration, cancer and other diseases, and how this knowledge leads to therapeutic opportunities.

Related Meeting

This GRC will be held in conjunction with the "Cell Growth and Proliferation" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Protein Degradation in Development and Disease Discussion Leader:
7:40 pm - 7:55 pm	Introduction by Discussion Leader
7:55 pm - 8:25 pm	Alexander M. Cruickshank Lecture: "Ubiquitin-Dependent Control of Cell Proliferation and Identity"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:05 pm	"Leveraging Proximity Biology for the Next Generation of Therapeutics"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Quantitative Proteomics Reveals a Widespread, PLK1-Regulated G2/M Degradation Program and Integration with PKA Signaling Through AKAP2"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Core Cell Cycle Machinery and Cell Division Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:40 am	"Understanding Cell Size Homeostasis and Size Sensing at Single Cell Level"
9:40 am - 9:50 am	Discussion
9:50 am - 10:15 am	"A Single Molecule Assay Allows the Visualization of Kinetochore Assembly and Function"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:05 am	"Identifying a novel regulator of mitotic Plk1"
11:05 am - 11:10 am	Discussion
11:10 am - 11:35 am	"Simple Rules of Intracellular Communication for Simulating Emergent Multicellular Organization"
11:35 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Unveiling a Novel Role of CDK4/6 in Mitosis and Genome Maintenance"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Multiple Cancer Types Rapidly Escape from Multiple MAPK Inhibitors to Generate Mutagenesis-Prone Subpopulations"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Cell Size Homeostasis Autonomously Determines G1/S Timing in Mammalian Skin Stem Cells"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Proliferation and Genome Stability Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Centromeric Chromatin Architecture and its Implications for Chromosome Segregation Fidelity"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Closing the Circle: from Gene Fusions to ecDNAs"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:45 pm	"Elucidating the Role of Amplified Enhancer Elements on Double Minutes in MYC-Amplified Medulloblastoma"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:00 pm	"Uncovering Novel Molecular Players in Cell Growth and Proliferation"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Chromosomal Instability as a Driver of Tumor Progression and Cellular Plasticity"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Mechanisms of Cell Cycle Progression and Quiescence Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:40 am	"Loss of Cdk4/6 Activity in S/G2 Phase Leads to Cell Cycle Reversal"
9:40 am - 9:50 am	Discussion
9:50 am - 10:15 am	"Getting Into and Out of G0"
10:15 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Discovery of Degraders for Treatment of MYCN-Driven Pediatric Cancers"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Deep Learning Characterization of Quiescence and Non-proliferative Cellular States"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Dissecting the Mechanism of the Mitotic Surveillance Pathway in Mouse Embryonic Stem Cells"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Cell Overgrowth During G1 Arrest Triggers an Osmotic Stress Response and Chronic p38 Activation to Promote Cell Cycle Exit"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Chemical Strategies for Restoring Tumor Suppressor Functions of the Retinoblastoma Protein"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Driving the Cell Cycle Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"Decoding Multisite Phosphorylation by CDKs"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Normal and Neoplastic G1 Progression"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:20 pm	"Cell Cycle Control and Morphogenesis in Early Drosophila Embryos"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Targeting Cyclin-Dependent Kinases Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Reversal of CDK6-mediated Resistance to CDK4/6 Inhibitors"
9:35 am - 9:45 am	Discussion
9:45 am - 9:55 am	"RB Regulates Cohesin Distribution to Repress Insulator Activity, Resulting in E2F-Independent Transcriptional Regulation"
9:55 am - 10:00 am	Discussion
10:00 am - 10:30 am	Coffee Break
10:30 am - 10:55 am	"Rapid Adaptation of CDK2 Inhibitors is Enabled by Plasticity of the CDK2/4/6-Rb-E2F Axis"
10:55 am - 11:05 am	Discussion
11:05 am - 11:15 am	"Oncogenic YAP Mediates Changes in Chromatin Accessibility and Activity that Drive Expression of the MybMuB (MMB) Cell Cycle Genes and Sensitizes Cells to CHK1 inhibition"
11:15 am - 11:20 am	Discussion
11:20 am - 11:45 am	"CDK4 and CDK6 Kinases: From Basic Science to Cancer Therapy"
11:45 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"A State of Partial Rb-E2F Activation Safeguards Proliferation Commitment"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Plasticity of the Rb-E2F Pathway and External Signaling Coordinate CDK4/6-Independent Cell Cycle Entry"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Signaling Pathways in Development and Cancer Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Tumor Intrinsic Signaling Pathways in Immune Escape in Liver Cancer"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:25 pm	"Targeting Cell Cycle Transitions in Cancer Cells"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Targeting the Hippo Pathway in Cancers."
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Preclinical Development of PKMYT1 and ATR Inhibitor Combinations"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Genome Integrity and Immunity Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Coupling Replication-Dependent Histone Gene Expression to the Cell Cycle During Animal Development"
9:35 am - 9:40 am	Discussion
9:40 am - 10:05 am	"P53 Repurposes an Injury Response in Lung Cancer Suppression"
10:05 am - 10:10 am	Discussion
10:10 am - 10:40 am	Coffee Break
10:40 am - 11:05 am	"Dissecting the Roles and Targets of Aurora A kinase in Diploid and Tetraploid Mitosis"
11:05 am - 11:10 am	Discussion
11:10 am - 11:35 am	"Telomere R-Loops Trigger Phase Separation and Induce Alternative Lengthening of Telomeres upon BRCA2 Abrogation"
11:35 am - 11:45 am	Discussion
11:45 am - 12:00 pm	"Racing Against Time: c-Myc Overproduction Accelerates Origin Licensing in a Short G1 Phase."
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:20 pm	"Absence of a Cell Cycle Checkpoint to Monitor Completion of DNA Replication: Implications for Genome Stability and Cancer Development"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	System Biology and Genomics Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"Modeling Cell Fate Dynamics in the Microenvironment"
8:10 pm - 8:20 pm	Discussion
8:20 pm - 8:45 pm	"Using Unsupervised Machine Learning to Analyze Neuroblastoma Single Cells RNA Seq Data"
8:45 pm - 8:55 pm	Discussion
8:55 pm - 9:15 pm	General Discussion
9:15 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA284518. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health

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Conference History Cell Growth and Proliferation (GRS)

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