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Cell Growth and Proliferation (GRS)

Gordon Research Seminar

Bridging the Gap Between Foundational Research and Therapeutics

July 8 - 9, 2023

Chair

Conference Description

The Cell Growth and Proliferation GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The regulation of the cell cycle and signaling pathways influencing proliferation are critical for development, tissue and organ homeostasis in all multicellular organisms. Dysregulation of the cell cycle plays a causal role in many disorders, most notable of which is cancer. The 2023 Gordon Research Seminar on Cell Growth and Proliferation will provide graduate students, post-doctoral researchers and other early-career trainees studying cell proliferation a forum to share and learn about the latest developments and form collaborations within the field. This GRS is held in conjunction with the Gordon Research Conference on Cell Growth and Proliferation which will feature leading scientists in the field.

Related Meeting

This GRS will be held in conjunction with the "Cell Growth and Proliferation" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Signaling Pathways and Cell Growth Regulation Discussion Leader:
3:45 pm - 3:50 pm	Introduction by Discussion Leader
3:50 pm - 4:25 pm	"Triple Threat: Multi-Modal Model Systems in Therapeutic Discovery for High-Grade Gliomas"
4:25 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cell cycle and disease Discussion Leader:
7:30 pm - 7:40 pm	"Understanding and Identifying the Impact of Amplified Regulatory DNA Regions on Double Minute Chromatin Bodies in MYC-Amplified Medulloblastomas"
7:40 pm - 7:45 pm	Discussion
7:45 pm - 7:55 pm	"The Paradox of Premature Checkpoint Recovery of BRCA/PALB2 Deficient Cells Following Ionizing Radiation-Induced DNA Damage"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:10 pm	"Cancer Cell Non-autonomous Tumor Progression from Chromosomal Instability"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:25 pm	"Chromosomal Instability Mediates Anti-Tumor Immunity in Pancreatic Cancer"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:40 pm	"Proteomic Analysis Reveals a Plk1-Dependent G2/M Degradation Program"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"A State of Partial Rb-E2F Activation Safeguards Proliferation Commitment"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Dissecting the Mechanism of the Mitotic Surveillance Pathway in Mouse Embryonic Stem Cells"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Molecular Control of Cell Growth Discussion Leader:
9:00 am - 9:10 am	"The Adapter Protein FADD Provides an Alternate Pathway for Entry into the Cell Cycle by Regulating APC/C-Cdh1 E3 Ubiquitin Ligase Activity"
9:10 am - 9:15 am	Discussion
9:15 am - 9:25 am	"Epigenetic Dysregulation from Chromosomal Transit in Micronuclei"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Increase in Cell Size Globally Remodels the Proteome and Promotes Senescence"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Cell Size Control in a Changing Environment"
9:55 am - 10:00 am	Discussion
10:00 am - 10:10 am	"RB Regulates Cohesin Distribution to Repress Insulator Activity, Resulting in E2F-Independent Transcriptional Regulation"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"APC/C Activity is Essential to Maintain Drug-Induced Cell Cycle Arrest"
10:25 am - 10:30 am	Discussion
10:30 am - 10:40 am	"Unraveling the Regulatory Mechanism of Rb Protein Concentration Through the Cell Division Cycle"
10:40 am - 10:45 am	Discussion
10:45 am - 10:55 am	"Cell Adhesion Molecules Regulate Cell Cycle Progression in Pancreatic Cancer"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Growth control in development Discussion Leader:
1:30 pm - 1:40 pm	"YAP-dependent Reprogramming of a Proliferative Cellular State"
1:40 pm - 1:45 pm	Discussion
1:45 pm - 1:55 pm	"Racing Against Time: C-Myc Overproduction Accelerates Origin Licensing in a Short G1 Phase"
1:55 pm - 2:00 pm	Discussion
2:00 pm - 2:10 pm	"Wee1 is Necessary for Timely S-Phase Entry"
2:10 pm - 2:15 pm	Discussion
2:15 pm - 2:25 pm	"mTOR-mediated Transient APC/C Inactivation Ensures Proper Cell Cycle Entry"
2:25 pm - 2:30 pm	Discussion
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under Award Number R13CA284518. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Cell Growth and Proliferation

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