Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Molecular Dynamics at the Centromere and the Mitotic Spindle
Discussion Leader: Gary Karpen (University of California, Berkeley, United States)
3:45 pm - 4:20 pm
Rebecca Heald (University of California, Berkeley, United States)
"Molecular Conflicts Disrupting Centromere Maintenance Contribute to Xenopus Hybrid Incompatability"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structure and Function at the Centromere
Discussion Leaders: Yael Nechemia-Arbely (UPMC Hillman Cancer Center / University of Pittsburgh School of Medicine, United States) and Patrick Heun (University of Edinburgh / Technical University Darmstadt, Germany)
7:30 pm - 7:45 pm
Gabriel Birchak (University of Pennsylvania, United States)
"Extending the Reach of Single-Copy HACs with Protein-Only Epigenetic Centromere Seeding"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Duccio Conti (Max Planck Institute of Molecular Physiology, Germany)
"Role of PLK1 in the Epigenetic Maintenance of Centromeres"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Rajesh Ranjan (Howard Hughes Medical Institute Inc, United States)
"Asynchronous DNA Synthesis Establishes Epigenetic Asymmetry at Sister Centromeres, and Regulates De-Differentiation in a Stem Cell Lineage"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Adriana Landeros (Northwestern University, United States)
"Nuclear Lamin A-Associated Proteins are Required for Centromere Assembly"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Lorena Andrade Ruiz (Hubrecht Institute, The Netherlands)
"Condensin I and II Specific Contributions to the Bipartite Centromere Organization"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Yusuke Takenoshita (Osaka University, Japan)
"The Molecular Basis and Regulation of the CENP-T–Mis12C Interaction in Chicken DT40 Cells"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Genetics and Epigenetics of Centromeric Chromatin
Discussion Leaders: Karen Miga (University of California, Santa Cruz, United States) and Simona Giunta (University of Rome Sapienza, Italy)
9:00 am - 9:15 am
Megan Mahlke (University of Pittsburgh Medical Center, United States)
"Human Centromeres Drift Through Cellular Proliferation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Danilo Dubocanin (Stanford University, United States)
"Conservation of Chromatin Organization Within Human and Primate Centromeres"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Matthew Naish (University of Cambridge, United Kingdom)
"Epigenome Regulation of Centromeres in Arabidopsis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Annapaola Angrisani (Institut Curie, Paris, France)
"Specialized Replication Mechanisms Maintain Genome Stability at Human Centromeres"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Rebecca Piri (University of Georgia, United States)
"Centromere and Neocentromere Repeats in Maize"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Sarah Gilmour (Stowers Institute for Medical Research, United States)
"Determining the Functional Consequences of Extant Centromeric Sequence Variation"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: An Early Career in Science
Discussion Leader: Damian Dudka (University of Pennsylvania, United States)
1:30 pm - 2:30 pm
Panel Discussion
An Early Research Career in Academia and Industry
Jessica Fellmeth (Millersville University, United States)
Bradley French (Novartis, United States)
Simona Giunta (University of Rome Sapienza, Italy)
Gary Karpen (University of California, Berkeley, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes