Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Peptide Engineering and Biology
7:40 pm - 8:20 pm
"How Do Hsp70 Molecular Chaperones Recognize Their Client Proteins? The Molecular Origins of 'Promiscuous Selectivity'"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Peptide-Polymer Conjugates for Therapeutic DNA Delivery"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Chemical Biology of Peptides
9:00 am - 9:25 am
"New Strategies for Selective Recognition and Sensing of Post-Translational Modifications in Histone Peptides"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Customizing Macromolecules Through Chemical Ligation"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Utilizing Peptide-Based Tools to Investigate Cell-Cell Communication in Bacteria"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Machine Learning-Enabled Design of Cell-Penetrating Peptides"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Facile Biocatalytic Synthesis of Hydroxylated Non-Canonical Amino Acids"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:55 pm
"Hierarchical Assembly of Collagen and Coiled Coil Peptide Motifs for Regenerative Medicine"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Engineering Peptide-Based Complex Coacervates for Therapeutic Delivery"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Exploiting Peptides to Overcome Barriers in Nanomedicine and Drug Delivery"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
9:00 am - 9:25 am
"The Supramolecular Chemistry of the Antibiotic Teixobactin"
9:25 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Anti-HIV-1 Activity and Mode of Action of a Viral-Derived and Proteolysis-Resistant Peptide CXCR4 Antagonist"
9:55 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:55 am
"Targeting Huntingtin Misfolding Using Conformationally Specific Binders: Implications for Therapy and Biomarker Development in Huntington's Disease"
10:55 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Neuronal Imaging with Selective Nav1.7 Targeted Peptides"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Structure Based Design Targeting the The Neuropeptide Receptor RXFP3"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Computational Peptide Design
7:30 pm - 7:55 pm
"Computational Peptide Design for Targeted Therapeutics"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Enhanced Sampling of Peptide Hairpin Loops to Map out Unusual Folds and Functions"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Experimentally-Constrained Computational Models for Studying Dynamic Proteins and Designing Synthetic Peptides"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Peptide Libraries and Lead Discovery
9:00 am - 9:25 am
"Laying the Foundation for Performing Drug Discovery on the Yeast Surface"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Directed Evolution of Cyclic Peptides for Inhibition of Autophagy in Ovarian Cancer"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
"Stabilization of 14-3-3 Protein-Protein Interactions as a Drug Discovery Strategy"
11:15 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Phage Display Selection of Peptides that Resist Proteases in the Gastrointestinal Tract"
11:45 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Displayable Pseudo-Natural Products"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Therapeutics: From Clinical Trials to Market
7:30 pm - 7:55 pm
"Recent Developments and Insights in the Discovery of GLP-1/Glucagon Agonists for the Treatment of Diabetes and Obesity"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Illustrations of Harnessing Intrinsic Properties of Peptides for Therapeutic Benefits with Discovery and Development of Macimorelin and ALRN-6924"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Developing Peptides into Drugs for Intracellular Targets: Lessons Learned from p53/MDMX"
9:15 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Peptide Chemistry, Synthesis and Biosynthesis
9:00 am - 9:25 am
"Synthetic Biology Approaches to Bioorthogonal Chemistry"
9:25 am - 9:40 am
Discussion
9:40 am - 10:05 am
"Selenium as a Tool for Chemical Synthesis and Folding of Proteins"
10:05 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:05 am
"Self-Assembled Hybrid Collagen/Cell Penetrating Peptides in Drug Delivery Applications"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
"Chemical Tools Selective Recognition of Posttranslational Modifications"
11:35 am - 11:50 am
Discussion
11:50 am - 12:15 pm
"Genome Mining of Fungal Nonribosomal Peptides"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Peptide Pathologies and Vaccines
7:30 pm - 7:55 pm
"Immunogenicity of Peptide Drugs and Their Impurities: Taspoglutide Case Study"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Chemical Functionality of Multidomain Peptide Hydrogels Governs Early Host Immune Responses"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Activity-Based Probes with Unnatural Amino Acids to Monitor the Proteasome in Live Cells"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure