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Chemistry and Biology of Peptides

Gordon Research Conference

Exploring the Natural and Unnatural of Peptide Science

October 30 - November 4, 2022

Chairs

and

Vice Chairs

and

Residence Inn at Oxnard River Ridge

2101 West Vineyard Ave

Oxnard, California, United States

Venue and Travel Information

Conference Description

The 2022 GRC Chemistry and Biology of Peptides conference will highlight the diversity of peptide science. Attendees will engage in discussions regarding discoveries, challenges and advances in the design, synthesis, characterization and translation of peptides. Sessions focusing on chemical biology and organic synthesis will be enhanced with sessions covering topics including AI, oncology, peptide materials, natural and unnatural products, advances in green chemistry, biosynthesis and other exciting areas of peptide research.

Related Meeting

This GRC will be held in conjunction with the "Chemistry and Biology of Peptides" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Exploration of Protein Function Discussion Leaders: and
7:40 pm - 7:50 pm	Introduction by Discussion Leader
7:50 pm - 8:25 pm	"Janus Particles: On the Role of Molecular Symmetry in Epigenetic Regulation"
8:25 pm - 8:40 pm	Discussion
8:40 pm - 9:15 pm	"Writing the Rules for Targeting Dynamic Transcriptional Coactivators"
9:15 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Peptide Chemistry, Synthesis and Biosynthesis Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"New Tools for Solid-Phase Peptide Synthesis"
9:30 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Bilingual Biopolymers: Harnessing Dual Information Codes to Control Assembly"
10:10 am - 10:25 am	Discussion
10:25 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Engineering Enzymes for Green Manufacturing of Noncanonical Amino Acids"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Synthetic Strategies for the Late-Stage Modification of Peptides"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Genetically Encoded Fragment-Based Discovery from Phage-Displayed Macrocyclic Libraries with Genetically Encoded Unnatural Pharmacophores"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Late-stage azapeptide functionalizations"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Peptides in Oncology Discussion Leaders: and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Peptide Production Re-invented: Connecting Synthesis, Analysis, Purification and Delivery with a Digital Thread"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Lasso Peptides as a New Therapeutic Modality"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Disrupting WASF3-Mediated Metastasis via Constrained Peptides"
8:55 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Peptide B-Cell Epitope Vaccines Synergizes with Combination Checkpoint Blockade Immunotherapy in Solid Tumors"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Peptide Chemistry and Biology Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Gate2Brain Opening the Gate to Cure CNS Diseases"
9:30 am - 9:45 am	Discussion
9:45 am - 10:10 am	"New Paradigms for GPCR Signaling in Neuroscience"
10:10 am - 10:25 am	Discussion
10:25 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Perspectives on Sustainable Peptide Synthesis in the Context of Circular Economy"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Late-Breaking Topic
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Flow-Based Methods in Peptide Chemistry"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Controlling Reactions on the Surfaces of Peptide Self-Assembled Structures"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Peptide Materials Discussion Leaders: and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Collagen Hybridizing Peptides and Peptoids: From Protein Folding to Disease Targeting"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Building Beyond Biology: Bioinspired Materials with Non-Natural Adaptive Capabilities"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Development of Antimicrobial Peptide-Based Methods for Biomedical Applications"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Design and Synthesis of Programmable 2D and 3D Peptide-Based Materials"
9:20 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Chemical Biology of Peptides Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"Rational Design of Pan-Ras Inhibitors: A Journey with Twists and Turns"
9:30 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Transition Metals in Peptide and Protein Synthesis"
10:10 am - 10:25 am	Discussion
10:25 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Photoswitchable Peptides as Tools for Light-Controlled Modulation of Protein Complexes"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	Late-Breaking Topic
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Aggressively Passive: Achieving Truly Small-Molecule-Like Properties in bRo5 Macrocyclic Peptides"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Minimalist Beta-Strand Mimics Targeting Amyloid Assemblies"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
7:30 pm - 9:30 pm	Peptide Therapeutics: From Clinical Trials to Market Discussion Leaders: and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:00 pm	"Identification of a PCSK9-LDLR Disruptor Peptide with In Vivo Function"
8:00 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Discovery and Development of Rusfertide (PTG-300) for the Treatment of Polycythemia Vera (PV)"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Invention of Macrocyclic Peptide PCSK9 Inhibitors"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"mRNA Display Platform for the Discovery of Natural Product-like Macrocyclic Peptides"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Peptide Tools, Technologies, and Techniques Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:30 am	"NMR Search for Hidden Transient Structure in Disordered Polypeptides by Chemical Denaturation"
9:30 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Semi-Synthesis of Membrane Proteins Using Protein Trans-Splicing"
10:10 am - 10:25 am	Discussion
10:25 am - 10:50 am	Coffee Break
10:50 am - 11:10 am	"Using Machine Learning and Artificial Intelligence for Peptide and Protein Design"
11:10 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Sensitivity Enhanced NMR for Structural Biology Inside Cells"
11:35 am - 11:40 am	Discussion
11:40 am - 11:55 am	"Biocatalysis and Complex Molecule Synthesis"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Toward Digital Antibiotic Discovery"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Pushing the Boundaries of Peptide Science Discussion Leaders: , and
7:30 pm - 7:40 pm	Introduction by Discussion Leader
7:40 pm - 8:15 pm	"Structure Prediction of Cyclic Peptides Using Molecular Dynamics and Machine Learning"
8:15 pm - 8:30 pm	Discussion
8:30 pm - 9:05 pm	"Programmed Synthesis of Unusual Peptides and Proteins"
9:05 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Australian Peptide Association

Funding for this conference was made possible (in part) by Grant Number 1R13TR003934-01 from the National Center for Advancing Translational Sciences (NCATS). The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

Conference Links

Conference History Chemistry and Biology of Peptides (GRS)

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